Melatonin protects endothelial progenitor cells against AGE-induced apoptosis via autophagy flux stimulation and promotes wound healing in diabetic mice

• Published in: Experimental & molecular medicine Vol. 50; no. 11; pp. 1 - 15
• Main Authors: Jin, Haiming, Zhang, Zengjie, Wang, Chengui, Tang, Qian, Wang, Jianle, Bai, Xueqin, Wang, Qingqing, Nisar, Majid, Tian, Naifeng, Wang, Quan, Mao, Cong, Zhang, Xiaolei, Wang, Xiangyang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.11.2018; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/1; 13/100; 13/2; 14/1; 14/35; 14/63; 631/532/489; 631/80/304; 631/80/86/2366; 64/60; Animals; Apoptosis; Autophagy; Biomedical and Life Sciences; Biomedicine; Bone marrow; Cells, Cultured; Chloroquine; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - drug therapy; Diabetic Angiopathies - drug therapy; Endothelial Progenitor Cells - drug effects; Endothelial Progenitor Cells - metabolism; Glycation End Products, Advanced - metabolism; Glycosylation; Male; Medical Biochemistry; Melatonin; Melatonin - pharmacology; Melatonin - therapeutic use; Membrane proteins; Mice; Mice, Inbred ICR; Molecular Medicine; p62 Protein; Phagocytosis; Pineal gland; Progenitor cells; Protein Kinases - metabolism; Signal transduction; Stem Cells; Streptozocin; TOR protein; TOR Serine-Threonine Kinases - metabolism; Wound Healing
• ISSN: 1226-3613; 2092-6413; 2092-6413
• DOI: 10.1038/s12276-018-0177-z

Wound healing is delayed in diabetic patients. Increased apoptosis and endothelial progenitor cell (EPC) dysfunction are implicated in delayed diabetic wound healing. Melatonin, a major secretory product of the pineal gland, promotes diabetic wound healing; however, its mechanism of action remains u...