A thorough QT study to assess the effects of tbo-filgrastim on cardiac repolarization in healthy subjects - Adar, Liat; Avisar, Noa; Lammerich, Andreas; Kleiman, Robert B.; Spiegelstein, Ofer (Drug design, development and therapy, 2015)
Keywords: Active control; Adult; Antineoplastic drugs; Antitumor agents; Blood pressure; Cancer therapies; Chemotherapy; Colony-stimulating factor; Conduction; Confidence intervals; Dosage and administration; Double-Blind Method; Drug dosages; Drug metabolism; EKG; Electrocardiography; Family medical history; FDA approval; Female; Filgrastim - adverse effects; Fluoroquinolones - adverse effects; Granulocyte colony-stimulating factor; Granulocytes; Heart function tests; Heart rate; Heart Rate - drug effects; Hematologic Agents - adverse effects; Humans; Infusions, Intravenous; Intravenous administration; Laboratories; Leukocytes (granulocytic); Male; Moxifloxacin; Neutropenia; Observations; Original Research; Pharmaceuticals; Young Adult; United States--US; Israel; QT interval; electrocardiogram; tbo-filgrastim; granulocyte colony-stimulating factor