Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu’s arteritis

• Published in: Arthritis research & therapy Vol. 27; no. 1; pp. 11 - 15
• Main Authors: Guo, Shuning, Li, Jiehan, Pang, Shurui, Li, Jing, Tian, Xinping
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.01.2025; BioMed Central; BMC
• Subjects: Adult; Analysis; Apoptosis; Care and treatment; Cell Movement; Cell Proliferation; Cells, Cultured; Coculture Techniques; Diagnosis; Exosome; Exosomes - genetics; Exosomes - metabolism; Female; Genetic aspects; Genetic markers; Humans; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; Male; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miRNA; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Phenotype; Takayasu Arteritis - genetics; Takayasu Arteritis - metabolism; Takayasu Arteritis - pathology; Takayasu's arteritis; Vascular remodeling; Vascular Remodeling - genetics; Vascular Remodeling - physiology; Vascular smooth muscle cells; China; Vascular remodeling; miRNA; Takayasu’s arteritis; Exosome; Vascular smooth muscle cells

Advances in treatment have swiftly alleviated systemic inflammation of Takayasu's arteritis (TAK), while subclinical vascular inflammation and the ensuing arterial remodeling continue to present unresolved challenges in TAK. The phenotypic switching of vascular smooth muscle cells (VSMC) is reg...