Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity

• Published in: Cell death discovery Vol. 4; no. 1; pp. 105 - 9
• Main Authors: Li, Ying-Wei, Xu, Jian, Zhu, Guo-Yuan, Huang, Zhu-Juan, Lu, Yan, Li, Xian-Qian, Wang, Neng, Zhang, Feng-Xue
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.11.2018; Springer Nature B.V
• Subjects: 631/67; 631/92; Apoptosis; Biochemistry; Biomedical and Life Sciences; Breast cancer; Cell Biology; Cell Cycle Analysis; Cell migration; Cell proliferation; Chemotherapy; Connective tissue growth factor; CYR61 protein; Life Sciences; Metastases; Stem Cells; Therapeutic applications; Yes-associated protein

Triple-negative breast cancer (TNBC) remains a clinical challenge because of the absence of effective therapeutic targets. In TNBC, overexpression of YAP and TAZ correlates with bioactivities of cancer stem cells (CSCs), high histological grade, resistance to chemotherapy, and metastasis. Thus, YAP/...