Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice - Chao, Xiaojuan; Wang, Shaogui; Zhao, Katrina; Li, Yuan; Williams, Jessica A.; Li, Tiangang; Chavan, Hemantkumar; Krishnamurthy, Partha; He, Xi C.; Li, Linheng; Ballabio, Andrea; Ni, Hong-Min; et al. (Gastroenterology (New York, N.Y. 1943), 2018)
Keywords: Animals; Autophagy - genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - physiology; Ethanol; Fatty Liver; Fatty Liver - genetics; Gene Regulation; Hepatic Protection; Hepatocytes - physiology; Liver - metabolism; Liver Diseases, Alcoholic - genetics; Lysosomes - physiology; Mice; Mice, Knockout; Mouse Model; Organelle Biogenesis; TOR Serine-Threonine Kinases - physiology; GTP; Ad; PGC1α; ALT; EtOH; Gene Regulation; GFP; ATP6V1H; ATP6V1D; LC3; Ly6B; WT; Mouse Model; ATP6V0E1; KO; Lamp1; H&E; AH; TFE3; TFEB; DKO; TSC1; Ctrl; EGTA; PKCβ; Fatty Liver; Hepatic Protection; ERK1/2; TG; Tor; ALD; LDs; Leu; mTORC1