Altered avalanche dynamics in a developmental NMDAR hypofunction model of cognitive impairment

• Published in: Translational psychiatry Vol. 8; no. 1; p. 3
• Main Authors: Seshadri, Saurav, Klaus, Andreas, Winkowski, Daniel E., Kanold, Patrick O., Plenz, Dietmar
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.01.2018; Nature Publishing Group
• Subjects: 631/378; 631/443; Animals; Antagonist drugs; Behavioral Sciences; Biological Psychology; Cognitive ability; Cognitive Dysfunction - chemically induced; Cognitive Dysfunction - metabolism; Excitatory Amino Acid Antagonists - toxicity; Female; GABA-B Receptor Agonists - pharmacology; Interneurons - metabolism; Medicine; Medicine & Public Health; Memory, Short-Term - drug effects; Memory, Short-Term - physiology; Neurosciences; Pharmacotherapy; Psychiatry; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - metabolism; Rodents; Schizophrenia - chemically induced; Schizophrenia - metabolism; Signal Transduction - drug effects

Disturbed activity patterns in cortical networks contribute to the pathophysiology of schizophrenia (SZ). Several lines of evidence implicate NMDA receptor hypofunction in SZ, and blocking NMDA receptor signaling during early neurodevelopment produces cognitive deficits in rodent models that resembl...