Altered avalanche dynamics in a developmental NMDAR hypofunction model of cognitive impairment

Disturbed activity patterns in cortical networks contribute to the pathophysiology of schizophrenia (SZ). Several lines of evidence implicate NMDA receptor hypofunction in SZ, and blocking NMDA receptor signaling during early neurodevelopment produces cognitive deficits in rodent models that resembl...

Full description

Saved in:
Bibliographic Details
Published inTranslational psychiatry Vol. 8; no. 1; p. 3
Main Authors Seshadri, Saurav, Klaus, Andreas, Winkowski, Daniel E., Kanold, Patrick O., Plenz, Dietmar
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 10.01.2018
Nature Publishing Group
Subjects
631/378
631/443
Animals
Antagonist drugs
Behavioral Sciences
Biological Psychology
Cognitive ability
Cognitive Dysfunction - chemically induced
Cognitive Dysfunction - metabolism
Excitatory Amino Acid Antagonists - toxicity
Female
GABA-B Receptor Agonists - pharmacology
Interneurons - metabolism
Medicine
Medicine & Public Health
Memory, Short-Term - drug effects
Memory, Short-Term - physiology
Neurosciences
Pharmacotherapy
Psychiatry
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate - metabolism
Rodents
Schizophrenia - chemically induced
Schizophrenia - metabolism
Signal Transduction - drug effects
Online AccessGet full text

Cover

Abstract Disturbed activity patterns in cortical networks contribute to the pathophysiology of schizophrenia (SZ). Several lines of evidence implicate NMDA receptor hypofunction in SZ, and blocking NMDA receptor signaling during early neurodevelopment produces cognitive deficits in rodent models that resemble those seen in schizophrenic patients. However, the altered network dynamics underlying these cognitive impairments largely remain to be characterized, especially at the cellular level. Here, we use in vivo two-photon calcium imaging to describe pathological dynamics, occurring in parallel with cognitive dysfunction, in a developmental NMDA receptor hypofunction model. We observed increased synchrony and specific alterations in spatiotemporal activity propagation, which could be causally linked to a previously unidentified persistent bursting phenotype. This phenotype was rescued by acute treatment with the NMDA receptor co-agonist D-serine or the GABA B receptor agonist baclofen, which similarly rescued working memory performance. It was not reproduced by optogenetic inhibition of fast-spiking interneurons. These results provide novel insight into network-level abnormalities mediating the cognitive impairment induced by NMDA receptor hypofunction.
AbstractList Disturbed activity patterns in cortical networks contribute to the pathophysiology of schizophrenia (SZ). Several lines of evidence implicate NMDA receptor hypofunction in SZ, and blocking NMDA receptor signaling during early neurodevelopment produces cognitive deficits in rodent models that resemble those seen in schizophrenic patients. However, the altered network dynamics underlying these cognitive impairments largely remain to be characterized, especially at the cellular level. Here, we use in vivo two-photon calcium imaging to describe pathological dynamics, occurring in parallel with cognitive dysfunction, in a developmental NMDA receptor hypofunction model. We observed increased synchrony and specific alterations in spatiotemporal activity propagation, which could be causally linked to a previously unidentified persistent bursting phenotype. This phenotype was rescued by acute treatment with the NMDA receptor co-agonist D-serine or the GABAB receptor agonist baclofen, which similarly rescued working memory performance. It was not reproduced by optogenetic inhibition of fast-spiking interneurons. These results provide novel insight into network-level abnormalities mediating the cognitive impairment induced by NMDA receptor hypofunction.
Disturbed activity patterns in cortical networks contribute to the pathophysiology of schizophrenia (SZ). Several lines of evidence implicate NMDA receptor hypofunction in SZ, and blocking NMDA receptor signaling during early neurodevelopment produces cognitive deficits in rodent models that resemble those seen in schizophrenic patients. However, the altered network dynamics underlying these cognitive impairments largely remain to be characterized, especially at the cellular level. Here, we use in vivo two-photon calcium imaging to describe pathological dynamics, occurring in parallel with cognitive dysfunction, in a developmental NMDA receptor hypofunction model. We observed increased synchrony and specific alterations in spatiotemporal activity propagation, which could be causally linked to a previously unidentified persistent bursting phenotype. This phenotype was rescued by acute treatment with the NMDA receptor co-agonist D-serine or the GABA B receptor agonist baclofen, which similarly rescued working memory performance. It was not reproduced by optogenetic inhibition of fast-spiking interneurons. These results provide novel insight into network-level abnormalities mediating the cognitive impairment induced by NMDA receptor hypofunction.
Disturbed activity patterns in cortical networks contribute to the pathophysiology of schizophrenia (SZ). Several lines of evidence implicate NMDA receptor hypofunction in SZ, and blocking NMDA receptor signaling during early neurodevelopment produces cognitive deficits in rodent models that resemble those seen in schizophrenic patients. However, the altered network dynamics underlying these cognitive impairments largely remain to be characterized, especially at the cellular level. Here, we use in vivo two-photon calcium imaging to describe pathological dynamics, occurring in parallel with cognitive dysfunction, in a developmental NMDA receptor hypofunction model. We observed increased synchrony and specific alterations in spatiotemporal activity propagation, which could be causally linked to a previously unidentified persistent bursting phenotype. This phenotype was rescued by acute treatment with the NMDA receptor co-agonist D-serine or the GABA receptor agonist baclofen, which similarly rescued working memory performance. It was not reproduced by optogenetic inhibition of fast-spiking interneurons. These results provide novel insight into network-level abnormalities mediating the cognitive impairment induced by NMDA receptor hypofunction.
ArticleNumber 3
Author Plenz, Dietmar
Kanold, Patrick O.
Seshadri, Saurav
Winkowski, Daniel E.
Klaus, Andreas
Author_xml – sequence: 1
  givenname: Saurav
  surname: Seshadri
  fullname: Seshadri, Saurav
  organization: Section on Critical Brain Dynamics, National Institute of Mental Health
– sequence: 2
  givenname: Andreas
  surname: Klaus
  fullname: Klaus, Andreas
  organization: Section on Critical Brain Dynamics, National Institute of Mental Health
– sequence: 3
  givenname: Daniel E.
  surname: Winkowski
  fullname: Winkowski, Daniel E.
  organization: Department of Biology, Univ. of Maryland
– sequence: 4
  givenname: Patrick O.
  orcidid: 0000-0002-7529-5435
  surname: Kanold
  fullname: Kanold, Patrick O.
  organization: Department of Biology, Univ. of Maryland
– sequence: 5
  givenname: Dietmar
  orcidid: 0000-0002-0008-3657
  surname: Plenz
  fullname: Plenz, Dietmar
  email: plenzd@mail.nih.gov
  organization: Section on Critical Brain Dynamics, National Institute of Mental Health
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29317600$$D View this record in MEDLINE/PubMed
BookMark eNp1UV2L1DAUDbLifrg_wBcJ-OJLNbdpmvRFGHZ1FVYF0VdDJr2dydImNWkHZn-9KbMuo2AeksA9Hzk55-TEB4-EvAD2BhhXb1MFvFEFA1kwVrPi_gk5K0GogoNSJ0f3U3KZ0h3LS1QKJDwjp2XDQdaMnZGfq37CiC01O9Mbb7dI2703g7OJOk8NbXGHfRgH9JPp6ZfP16tvdLsfQzd7O7ng6RBa7GnoqA0b7ya3Q-qG0bi4UJ6Tp53pE14-nBfkx4f3368-Frdfbz5drW4LK3g9FXWrjCo5r9bSdlCzjjWAQhkj19DIqmTWVFXewEpsoc0xurqzihtcc8ltyS_Iu4PuOK8HbG22jqbXY3SDiXsdjNN_T7zb6k3YaaFYWVUiC7x-EIjh14xp0oNLFvv8JxjmpKFRjRCC8cXr1T_QuzBHn-MtqLpkjEvIKDigbAwpReweHwNMLwXqQ4E6F6iXAvV95rw8TvHI-FNXBpQHQMojv8F4ZP1f1d87bqmF
CitedBy_id crossref_primary_10_1038_s41598_020_69705_5
crossref_primary_10_1103_PhysRevResearch_4_023057
crossref_primary_10_3389_fnsys_2019_00045
crossref_primary_10_1038_s41467_023_41020_3
crossref_primary_10_1088_2632_072X_ac266c
crossref_primary_10_1111_bph_16375
crossref_primary_10_1016_j_concog_2021_103212
crossref_primary_10_1186_s12864_021_07946_y
crossref_primary_10_3389_fnhum_2023_1130897
crossref_primary_10_1103_PhysRevE_98_062107
crossref_primary_10_3389_fphar_2020_635763
crossref_primary_10_1016_j_pneurobio_2022_102268
crossref_primary_10_1016_j_biopsych_2020_01_004
crossref_primary_10_1016_j_neuron_2018_10_045
crossref_primary_10_1016_j_neubiorev_2022_104810
crossref_primary_10_1016_j_ynstr_2018_09_001
crossref_primary_10_3389_fphy_2023_1150246
crossref_primary_10_3389_fnmol_2020_566251
Cites_doi 10.1073/pnas.0800537105
10.1038/sj.mp.4001558
10.1038/nn.2447
10.1038/35065675
10.1523/JNEUROSCI.3127-11.2011
10.1073/pnas.1513716112
10.1038/nn.2140
10.1038/mp.2011.31
10.1371/journal.pcbi.1002312
10.1523/JNEUROSCI.0333-10.2010
10.1038/nphys1803
10.1016/j.neuropharm.2011.02.007
10.1093/schbul/sbn062
10.1523/JNEUROSCI.4637-10.2011
10.1038/nature08897
10.1016/j.biopsych.2014.11.019
10.1103/PhysRevE.79.061922
10.1016/j.cell.2010.02.037
10.1093/cercor/bht329
10.1038/nature09552
10.1523/JNEUROSCI.4286-12.2013
10.3389/fpsyt.2016.00114
10.1103/PhysRevE.66.041904
10.1038/nphys289
10.1016/0006-3223(89)90147-9
10.1073/pnas.1216855110
10.1038/nrn.2016.53
10.1038/srep09745
10.3389/fncir.2015.00006
10.2174/138161210790361452
10.1523/JNEUROSCI.23-15-06315.2003
10.1001/archpsyc.57.1.65
10.1016/j.bbr.2007.07.033
10.1016/j.neuron.2009.01.008
10.3389/fphys.2012.00015
10.7554/eLife.07224
10.1038/nn.3051
10.1007/s00213-013-2999-7
10.1523/JNEUROSCI.0723-06.2006
10.1523/JNEUROSCI.5214-14.2015
10.1073/pnas.1208494109
10.1038/npp.2014.7
10.1523/JNEUROSCI.2601-12.2012
10.1523/JNEUROSCI.3864-09.2009
10.1093/schbul/sbs069
10.1371/journal.pone.0099761
10.1038/npp.2009.20
10.1038/nn.3077
10.1016/j.psychres.2008.06.032
10.1523/JNEUROSCI.23-35-11167.2003
10.1093/cercor/bhg084
10.1038/mp.2013.152
10.1152/jn.1989.61.5.900
10.1038/sj.npp.1300394
10.1073/pnas.0809141106
10.1140/epjst/e2012-01575-5
10.1073/pnas.0400417101
10.1016/j.biopsych.2014.07.011
10.1152/jn.01073.2009
10.1126/science.1167093
10.1093/schbul/sbr069
10.1523/JNEUROSCI.1516-13.2013
10.1038/tp.2012.69
10.1016/j.pnpbp.2011.04.009
10.1016/j.neuron.2017.03.019
10.1016/j.conb.2014.08.006
10.1097/WNP.0b013e3181fdf8d3
10.1016/0896-6273(95)90304-6
10.1016/j.neuron.2007.09.012
10.1093/cercor/bhs370
10.1038/nature10360
10.1073/pnas.0904089106
10.1038/nn1846
10.1016/j.neuron.2016.02.009
10.1111/bph.12518
10.1016/S0140-6736(15)01121-6
ContentType Journal Article
Copyright The Author(s) 2017
2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2017
– notice: 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
M1P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOI 10.1038/s41398-017-0060-z
DatabaseName SpringerOpen
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
AUTh Library subscriptions: ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Central China
ProQuest Hospital Collection (Alumni)
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest Medical Library
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest One Academic
ProQuest Medical Library (Alumni)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
CrossRef

MEDLINE
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: C6C
  name: SpringerOpen
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 7X7
  name: ProQuest_Health & Medical Collection
  url: https://search.proquest.com/healthcomplete
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2158-3188
EndPage 3
ExternalDocumentID 10_1038_s41398_017_0060_z
29317600
Genre Journal Article
Research Support, N.I.H., Intramural
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NINDS NIH HHS
  grantid: U01 NS090569
GroupedDBID ---
0R~
3V.
53G
5VS
7X7
88E
8FI
8FJ
AAJSJ
AAKDD
ABUWG
ACGFO
ACGFS
ACMJI
ACSMW
ADBBV
ADFRT
AENEX
AFKRA
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EJD
EMOBN
FYUFA
GROUPED_DOAJ
GX1
HMCUK
HYE
KQ8
M1P
M~E
NAO
NXXTH
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
UKHRP
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7XB
8FK
AZQEC
DWQXO
K9.
PQEST
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c536t-6d8a82334b7cf160f091e58aa7b197420ca440ca1c7ed1d481f6fc83aeb373c23
IEDL.DBID RPM
ISSN 2158-3188
IngestDate Tue Sep 17 21:27:50 EDT 2024
Fri Aug 16 20:40:22 EDT 2024
Sat Nov 23 11:54:51 EST 2024
Thu Nov 21 21:34:04 EST 2024
Sat Sep 28 08:36:28 EDT 2024
Fri Oct 11 20:51:45 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c536t-6d8a82334b7cf160f091e58aa7b197420ca440ca1c7ed1d481f6fc83aeb373c23
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-0008-3657
0000-0002-7529-5435
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802445/
PMID 29317600
PQID 1986200371
PQPubID 2041978
PageCount 1
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5802445
proquest_miscellaneous_1989555032
proquest_journals_1986200371
crossref_primary_10_1038_s41398_017_0060_z
pubmed_primary_29317600
springer_journals_10_1038_s41398_017_0060_z
PublicationCentury 2000
PublicationDate 2018-01-10
PublicationDateYYYYMMDD 2018-01-10
PublicationDate_xml – month: 01
  year: 2018
  text: 2018-01-10
  day: 10
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: United States
PublicationTitle Translational psychiatry
PublicationTitleAbbrev Transl Psychiatry
PublicationTitleAlternate Transl Psychiatry
PublicationYear 2018
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References FraimanDBalenzuelaPFossJChialvoDRIsing-like dynamics in large-scale functional brain networksPhys. Rev. E. Stat. Nonlin. Soft. Matter. Phys.2009796 Pt 106192210.1103/PhysRevE.79.061922196585392746490
NagaiTYamadaSTominagaTIchikawaMMiyawakiAExpanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteinsProc Natl Acad Sci U S A200410110554105591:CAS:528:DC%2BD2cXmtFWmsL8%3D10.1073/pnas.040041710115247428490022
HallJTrentSThomasKLO’DonovanMCOwenMJGenetic risk for schizophrenia: convergence on synaptic pathways involved in plasticityBiol. Psychiatr.20157752581:CAS:528:DC%2BC2cXhsV2lt7zE10.1016/j.biopsych.2014.07.011
AndersenJDPouzetBSpatial memory deficits induced by perinatal treatment of rats with PCP and reversal effect of D-serineNeuropsychopharmacology200429108010901:CAS:528:DC%2BD2cXktV2kurY%3D10.1038/sj.npp.130039414970828
KukiTContribution of parvalbumin and somatostatin-expressing GABAergic neurons to slow oscillations and the balance in beta-gamma oscillations across cortical layersFront Neural Circuit.20159610.3389/fncir.2015.00006
Carrillo-ReidLMillerJEHammJPJacksonJYusteREndogenous sequential cortical activity evoked by visual stimuliJ Neurosci201535881388281:CAS:528:DC%2BC2MXhtVOqs7vP10.1523/JNEUROSCI.5214-14.2015260639154461687
Whitfield-GabrieliSHyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophreniaProc Natl Acad Sci U S A.2009106127912841:CAS:528:DC%2BD1MXhsFyitL0%3D10.1073/pnas.0809141106191645772633557
YizharONeocortical excitation/inhibition balance in information processing and social dysfunctionNature.20114771711781:CAS:528:DC%2BC3MXhtFOls7nE10.1038/nature10360217961214155501
BelforteJEPostnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypesNat. Neurosci.20101376831:CAS:528:DC%2BD1MXhsVWlsLnJ10.1038/nn.244719915563
SachidhanandamSSermetBSPetersenCCParvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor TransformationCell Rep.2016S2211-12473033430335
RadonjicNVJakovcevskiIBumbasirevicVPetronijevicNDPerinatal phencyclidine administration decreases the density of cortical interneurons and increases the expression of neuregulin-1Psychopharmacology.20132276736831:CAS:528:DC%2BC3sXhvFKksLg%3D10.1007/s00213-013-2999-723380917
ShrikiONeuronal avalanches in the resting MEG of the human brain J Neurosci201333707970901:CAS:528:DC%2BC3sXhtlOjs7zE10.1523/JNEUROSCI.4286-12.2013235957653665287
VijayraghavanSWangMBirnbaumSGWilliamsGVArnstenAFInverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memoryNat. Neurosci.2007103763841:CAS:528:DC%2BD2sXitVGku74%3D10.1038/nn184617277774
PetermannTSpontaneous cortical activity in awake monkeys composed of neuronal avalanchesProc Natl Acad Sci U S A.200910615921159261:CAS:528:DC%2BD1MXhtFOqtrzP10.1073/pnas.0904089106197174632732708
FreundTFKatonaIPerisomatic inhibitionNeuron.20075633421:CAS:528:DC%2BD2sXht1Wksr%2FL10.1016/j.neuron.2007.09.01217920013
AertsenAGersteinGLHabibMKPalmGDynamics of neuronal firing correlation: modulation of “effective connectivity”J. Neurophysiol.1989619009171:STN:280:DyaL1M3lslGhug%3D%3D10.1152/jn.1989.61.5.9002723733
TsaiGELinPYStrategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysisCurr. Pharm. Des.2010165225371:CAS:528:DC%2BC3cXisVKjtbY%3D10.2174/13816121079036145219909229
Quian QuirogaRKreuzTGrassbergerPEvent synchronization: a simple and fast method to measure synchronicity and time delay patternsPhys. Rev. E. Stat. Nonlin. Soft. Matter. Phys.2002664 Pt 10419041:STN:280:DC%2BD3s%2FgsVWqtg%3D%3D10.1103/PhysRevE.66.04190412443232
JavittDCZukinSRHeresco-LevyUUmbrichtDHas an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophreniaSchizophr. Bull.20123895896610.1093/schbul/sbs069229878513446214
GlantzLALewisDADecreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophreniaArch. Gen. Psychiatr.20005765731:STN:280:DC%2BD3c%2Fps1Sqtw%3D%3D10.1001/archpsyc.57.1.6510632234
KayserCMontemurroMALogothetisNKPanzeriSSpike-phase coding boosts and stabilizes information carried by spatial and temporal spike patternsNeuron.2009615976081:CAS:528:DC%2BD1MXlt1KlsLc%3D10.1016/j.neuron.2009.01.00819249279
GandalMJEdgarJCKlookKSiegelSJGamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophreniaNeuropharmacology.201262150415181:CAS:528:DC%2BC38XhtFWksbw%3D10.1016/j.neuropharm.2011.02.00721349276
MeiselCStorchAHallmeyer-ElgnerSBullmoreEGrossTFailure of adaptive self-organized criticality during epileptic seizure attacksPLoS. Comput. Biol.20128e10023121:CAS:528:DC%2BC38XhtVyisbo%3D10.1371/journal.pcbi.1002312222419713252275
BlotKModulation of hippocampus-prefrontal cortex synaptic transmission and disruption of executive cognitive functions by MK-801Cereb. Cortex.2015251348136110.1093/cercor/bht32924304584
LynallMEFunctional connectivity and brain networks in schizophreniaJ Neurosci201030947794871:CAS:528:DC%2BC3cXpslSisr0%3D10.1523/JNEUROSCI.0333-10.2010206311762914251
DiwadkarVAWorking memory and attention deficits in adolescent offspring of schizophrenia or bipolar patients: comparing vulnerability markersProg. Neuropsychopharmacol. Biol. Psychiatr.2011351349135410.1016/j.pnpbp.2011.04.009
MeiselCOlbrichEShrikiOAchermannPFading signatures of critical brain dynamics during sustained wakefulness in humansJ. Neurosci.20133317363173721:CAS:528:DC%2BC3sXhslCjtrfN10.1523/JNEUROSCI.1516-13.2013241746693858643
PalvaJMNeuronal long-range temporal correlations and avalanche dynamics are correlated with behavioral scaling lawsProc Natl Acad Sci U S A.2013110358535901:CAS:528:DC%2BC3sXkvFynt7s%3D10.1073/pnas.1216855110234015363587255
GireeshEDPlenzDNeuronal avalanches organize as nested theta- and beta/gamma-oscillations during development of cortical layer 2/3Proc Natl Acad Sci U S A.2008105757675811:CAS:528:DC%2BD1cXmvFKkt70%3D10.1073/pnas.0800537105184998022396689
HashimotoTGene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia J Neurosci.200323631563261:CAS:528:DC%2BD3sXlvVCgs7c%3D12867516
AkerboomJOptimization of a GCaMP calcium indicator for neural activity imaging J Neurosci.20123213819138401:CAS:528:DC%2BC38XhsVyqsrvF10.1523/JNEUROSCI.2601-12.2012230350933482105
CarlenMA critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behaviorMol. Psychiatr.2012175375481:CAS:528:DC%2BC38XlvFSntrw%3D10.1038/mp.2011.31
UhlhaasPJSingerWOscillations and Neuronal Dynamics in Schizophrenia: The Search for Basic Symptoms and Translational OpportunitiesBiol. Psychiatr.2015771001100910.1016/j.biopsych.2014.11.019
StewartCVPlenzDInverted-U profile of dopamine-NMDA-mediated spontaneous avalanche recurrence in superficial layers of rat prefrontal cortexJ Neurosci200626814881591:CAS:528:DC%2BD28XosVeiu7c%3D10.1523/JNEUROSCI.0723-06.200616885228
Urban-CieckoJBarthALSomatostatin-expressing neurons in cortical networksNat. Rev. Neurosci.2016174014091:CAS:528:DC%2BC28Xos1Wqsb0%3D10.1038/nrn.2016.53272250745635659
RoyerSControl of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibitionNat. Neurosci.2012157697751:CAS:528:DC%2BC38XksVehtLc%3D10.1038/nn.3077224468784919905
OwenMJSawaAMortensenPBSchizophreniaLancet.2016388869710.1016/S0140-6736(15)01121-6267779174940219
Edwin ThanarajahSAbnormal Connectional Fingerprint in Schizophrenia: A Novel Network Analysis of Diffusion Tensor Imaging DataFront Psychiatr.2016711410.3389/fpsyt.2016.00114
Sanchez-MorlaEMComparative study of neurocognitive function in euthymic bipolar patients and stabilized schizophrenic patientsPsychiatry. Res.200916922022810.1016/j.psychres.2008.06.03219758705
YuSKlausAYangHPlenzDScale-invariant neuronal avalanche dynamics and the cut-off in size distributionsPLoS. ONE.20149e9976110.1371/journal.pone.0099761249271584057403
MurrayJDLinking microcircuit dysfunction to cognitive impairment: effects of disinhibition associated with schizophrenia in a cortical working memory modelCereb. Cortex.20142485987210.1093/cercor/bhs37023203979
GradinaruVMogriMThompsonKRHendersonJMDeisserothKOptical deconstruction of parkinsonian neural circuitryScience20093243543591:CAS:528:DC%2BD1MXksVOlt7Y%3D10.1126/science.116709319299587
MarsmanAGlutamate in schizophrenia: a focused review and meta-analysis of (1)H-MRS studiesSchizophr. Bull.20133912012910.1093/schbul/sbr06921746807
UhlhaasPJHaenschelCNikolicDSingerWThe role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophreniaSchizophr. Bull.20083492794310.1093/schbul/sbn062185623442632472
ShewWLYangHYuSRoyRPlenzDInformation capacity and transmission are maximized in balanced cortical networks with neuronal avalanchesJ Neurosci2011315520631:CAS:528:DC%2BC3MXls1yitQ%3D%3D10.1523/JNEUROSCI.4637-10.2011212091893082868
TagliazucchiEBalenzuelaPFraimanDChialvoDRCriticality in large-scale brain fMRI dynamics unveiled by a novel point process analysisFront Physiol.201231510.3389/fphys.2012.00015223478633274757
KarasawaJHashimotoKChakiSD-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in ratsBehav. Brain. Res.200818678831:CAS:528:DC%2BD2sXhtlalsrzP10.1016/j.bbr.2007.07.03317854919
GradinaruVMolecular and cellular approaches for diversifying and extending optogeneticsCell.20101411541651:CAS:528:DC%2BC3cXlsVSgtbY%3D10.1016/j.cell.2010.02.037203031574160532
VogelsteinJTFast nonnegative deconvolution for spike train inference from population calcium imagingJ. Neurophysiol.20101043691370410.1152/jn.01073.2009205548343007657
Hamm J. P., Peterka D. S., Gogos J. A., Yuste R. Altered Cortical Ensembles in Mouse Models of Schizophrenia. Neuron. 2017;94:153-67.e8.
Insel
MJ Gandal (60_CR69) 2012; 62
MJ Gandal (60_CR40) 2012; 2
GE Tsai (60_CR50) 2010; 16
J Akerboom (60_CR45) 2012; 32
T Kuki (60_CR59) 2015; 9
S Royer (60_CR63) 2012; 15
JM Beggs (60_CR23) 2003; 23
TR Insel (60_CR20) 2010; 468
V Gradinaru (60_CR44) 2009; 324
JD Murray (60_CR66) 2014; 24
TF Freund (60_CR60) 2007; 56
D Fraiman (60_CR35) 2009; 79
C Kayser (60_CR73) 2009; 61
PJ Uhlhaas (60_CR17) 2015; 77
JP Sethna (60_CR55) 2001; 410
JP Hobbs (60_CR65) 2010; 27
T Petermann (60_CR32) 2009; 106
WL Shew (60_CR25) 2009; 29
A Aertsen (60_CR48) 1989; 61
K Blot (60_CR12) 2015; 25
C Meisel (60_CR79) 2012; 8
D Plenz (60_CR22) 2012; 205
PJ Uhlhaas (60_CR74) 2008; 34
MW Howard (60_CR29) 2003; 13
C Meisel (60_CR39) 2013; 33
LJ Gentet (60_CR64) 2012; 15
R Quian Quiroga (60_CR47) 2002; 66
PS Suryavanshi (60_CR13) 2014; 171
S Vijayraghavan (60_CR30) 2007; 10
V Gradinaru (60_CR57) 2010; 141
J Urban-Ciecko (60_CR62) 2016; 17
ME Lynall (60_CR78) 2010; 30
J Hall (60_CR4) 2015; 77
K Rajan (60_CR67) 2016; 90
PS Goldman-Rakic (60_CR49) 1995; 14
O Shriki (60_CR38) 2013; 33
ED Gireesh (60_CR27) 2008; 105
LA Glantz (60_CR71) 2000; 57
MJ Owen (60_CR2) 2016; 388
JE Belforte (60_CR11) 2010; 13
A Marsman (60_CR72) 2013; 39
T Nagai (60_CR42) 2004; 101
O Kinouchi (60_CR24) 2006; 2
VA Diwadkar (60_CR14) 2011; 35
JD Andersen (60_CR7) 2004; 29
C Meisel (60_CR33) 2013; 33
KM Spencer (60_CR18) 2011; 5
T Bellay (60_CR31) 2015; 4
M Carlen (60_CR6) 2012; 17
L Carrillo-Reid (60_CR51) 2015; 35
JR Glausier (60_CR8) 2014; 19
S Edwin Thanarajah (60_CR75) 2016; 7
S Sachidhanandam (60_CR58) 2016; S2211-1247
O Yizhar (60_CR43) 2011; 477
A Anticevic (60_CR77) 2012; 109
EM Sanchez-Morla (60_CR15) 2009; 169
T Hashimoto (60_CR9) 2003; 23
L Su (60_CR68) 2015; 5
DR Chialvo (60_CR21) 2010; 6
DC Javitt (60_CR3) 2012; 38
E Tagliazucchi (60_CR36) 2012; 3
NV Radonjic (60_CR10) 2013; 227
J Karasawa (60_CR41) 2008; 186
HX Wang (60_CR61) 2009; 34
S Yu (60_CR53) 2011; 31
EN Billingslea (60_CR5) 2014; 39
S Whitfield-Gabrieli (60_CR76) 2009; 106
DS Greenberg (60_CR52) 2008; 11
EL Merrin (60_CR70) 1989; 25
60_CR1
JM Palva (60_CR34) 2013; 110
S Yu (60_CR54) 2014; 9
JT Vogelstein (60_CR46) 2010; 104
60_CR19
C Meisel (60_CR37) 2015; 112
T Komiyama (60_CR56) 2010; 464
A Fornito (60_CR16) 2015; 30
CV Stewart (60_CR28) 2006; 26
WL Shew (60_CR26) 2011; 31
References_xml – volume: 105
  start-page: 7576
  year: 2008
  ident: 60_CR27
  publication-title: Proc Natl Acad Sci U S A.
  doi: 10.1073/pnas.0800537105
  contributor:
    fullname: ED Gireesh
– ident: 60_CR1
  doi: 10.1038/sj.mp.4001558
– volume: 13
  start-page: 76
  year: 2010
  ident: 60_CR11
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2447
  contributor:
    fullname: JE Belforte
– volume: 410
  start-page: 242
  year: 2001
  ident: 60_CR55
  publication-title: Nature.
  doi: 10.1038/35065675
  contributor:
    fullname: JP Sethna
– volume: 31
  start-page: 17514
  year: 2011
  ident: 60_CR53
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3127-11.2011
  contributor:
    fullname: S Yu
– volume: 112
  start-page: 14694
  year: 2015
  ident: 60_CR37
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1513716112
  contributor:
    fullname: C Meisel
– volume: 11
  start-page: 749
  year: 2008
  ident: 60_CR52
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2140
  contributor:
    fullname: DS Greenberg
– volume: 17
  start-page: 537
  year: 2012
  ident: 60_CR6
  publication-title: Mol. Psychiatr.
  doi: 10.1038/mp.2011.31
  contributor:
    fullname: M Carlen
– volume: 8
  start-page: e1002312
  year: 2012
  ident: 60_CR79
  publication-title: PLoS. Comput. Biol.
  doi: 10.1371/journal.pcbi.1002312
  contributor:
    fullname: C Meisel
– volume: 30
  start-page: 9477
  year: 2010
  ident: 60_CR78
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0333-10.2010
  contributor:
    fullname: ME Lynall
– volume: 6
  start-page: 744
  year: 2010
  ident: 60_CR21
  publication-title: Nat Phys.
  doi: 10.1038/nphys1803
  contributor:
    fullname: DR Chialvo
– volume: 62
  start-page: 1504
  year: 2012
  ident: 60_CR69
  publication-title: Neuropharmacology.
  doi: 10.1016/j.neuropharm.2011.02.007
  contributor:
    fullname: MJ Gandal
– volume: 34
  start-page: 927
  year: 2008
  ident: 60_CR74
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sbn062
  contributor:
    fullname: PJ Uhlhaas
– volume: 31
  start-page: 55
  year: 2011
  ident: 60_CR26
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4637-10.2011
  contributor:
    fullname: WL Shew
– volume: 464
  start-page: 1182
  year: 2010
  ident: 60_CR56
  publication-title: Nature.
  doi: 10.1038/nature08897
  contributor:
    fullname: T Komiyama
– volume: 77
  start-page: 1001
  year: 2015
  ident: 60_CR17
  publication-title: Biol. Psychiatr.
  doi: 10.1016/j.biopsych.2014.11.019
  contributor:
    fullname: PJ Uhlhaas
– volume: 79
  start-page: 061922
  issue: 6 Pt 1
  year: 2009
  ident: 60_CR35
  publication-title: Phys. Rev. E. Stat. Nonlin. Soft. Matter. Phys.
  doi: 10.1103/PhysRevE.79.061922
  contributor:
    fullname: D Fraiman
– volume: 141
  start-page: 154
  year: 2010
  ident: 60_CR57
  publication-title: Cell.
  doi: 10.1016/j.cell.2010.02.037
  contributor:
    fullname: V Gradinaru
– volume: 25
  start-page: 1348
  year: 2015
  ident: 60_CR12
  publication-title: Cereb. Cortex.
  doi: 10.1093/cercor/bht329
  contributor:
    fullname: K Blot
– volume: 468
  start-page: 187
  year: 2010
  ident: 60_CR20
  publication-title: Nature.
  doi: 10.1038/nature09552
  contributor:
    fullname: TR Insel
– volume: 33
  start-page: 7079
  year: 2013
  ident: 60_CR38
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4286-12.2013
  contributor:
    fullname: O Shriki
– volume: 7
  start-page: 114
  year: 2016
  ident: 60_CR75
  publication-title: Front Psychiatr.
  doi: 10.3389/fpsyt.2016.00114
  contributor:
    fullname: S Edwin Thanarajah
– volume: 66
  start-page: 041904
  issue: 4 Pt 1
  year: 2002
  ident: 60_CR47
  publication-title: Phys. Rev. E. Stat. Nonlin. Soft. Matter. Phys.
  doi: 10.1103/PhysRevE.66.041904
  contributor:
    fullname: R Quian Quiroga
– volume: 2
  start-page: 348
  year: 2006
  ident: 60_CR24
  publication-title: Nat Phys.
  doi: 10.1038/nphys289
  contributor:
    fullname: O Kinouchi
– volume: 25
  start-page: 60
  year: 1989
  ident: 60_CR70
  publication-title: Biol. Psychiatr.
  doi: 10.1016/0006-3223(89)90147-9
  contributor:
    fullname: EL Merrin
– volume: 110
  start-page: 3585
  year: 2013
  ident: 60_CR34
  publication-title: Proc Natl Acad Sci U S A.
  doi: 10.1073/pnas.1216855110
  contributor:
    fullname: JM Palva
– volume: 17
  start-page: 401
  year: 2016
  ident: 60_CR62
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2016.53
  contributor:
    fullname: J Urban-Ciecko
– volume: 5
  year: 2015
  ident: 60_CR68
  publication-title: Sci Rep.
  doi: 10.1038/srep09745
  contributor:
    fullname: L Su
– volume: 9
  start-page: 6
  year: 2015
  ident: 60_CR59
  publication-title: Front Neural Circuit.
  doi: 10.3389/fncir.2015.00006
  contributor:
    fullname: T Kuki
– volume: 16
  start-page: 522
  year: 2010
  ident: 60_CR50
  publication-title: Curr. Pharm. Des.
  doi: 10.2174/138161210790361452
  contributor:
    fullname: GE Tsai
– volume: 23
  start-page: 6315
  year: 2003
  ident: 60_CR9
  publication-title: J Neurosci.
  doi: 10.1523/JNEUROSCI.23-15-06315.2003
  contributor:
    fullname: T Hashimoto
– volume: 57
  start-page: 65
  year: 2000
  ident: 60_CR71
  publication-title: Arch. Gen. Psychiatr.
  doi: 10.1001/archpsyc.57.1.65
  contributor:
    fullname: LA Glantz
– volume: 186
  start-page: 78
  year: 2008
  ident: 60_CR41
  publication-title: Behav. Brain. Res.
  doi: 10.1016/j.bbr.2007.07.033
  contributor:
    fullname: J Karasawa
– volume: 61
  start-page: 597
  year: 2009
  ident: 60_CR73
  publication-title: Neuron.
  doi: 10.1016/j.neuron.2009.01.008
  contributor:
    fullname: C Kayser
– volume: 3
  start-page: 15
  year: 2012
  ident: 60_CR36
  publication-title: Front Physiol.
  doi: 10.3389/fphys.2012.00015
  contributor:
    fullname: E Tagliazucchi
– volume: 4
  start-page: e07224
  year: 2015
  ident: 60_CR31
  publication-title: eLife.
  doi: 10.7554/eLife.07224
  contributor:
    fullname: T Bellay
– volume: 15
  start-page: 607
  year: 2012
  ident: 60_CR64
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3051
  contributor:
    fullname: LJ Gentet
– volume: 227
  start-page: 673
  year: 2013
  ident: 60_CR10
  publication-title: Psychopharmacology.
  doi: 10.1007/s00213-013-2999-7
  contributor:
    fullname: NV Radonjic
– volume: 26
  start-page: 8148
  year: 2006
  ident: 60_CR28
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0723-06.2006
  contributor:
    fullname: CV Stewart
– volume: 35
  start-page: 8813
  year: 2015
  ident: 60_CR51
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.5214-14.2015
  contributor:
    fullname: L Carrillo-Reid
– volume: 5
  start-page: 190
  year: 2011
  ident: 60_CR18
  publication-title: Front Hum Neurosci.
  contributor:
    fullname: KM Spencer
– volume: 109
  start-page: 16720
  year: 2012
  ident: 60_CR77
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1208494109
  contributor:
    fullname: A Anticevic
– volume: 39
  start-page: 1603
  year: 2014
  ident: 60_CR5
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2014.7
  contributor:
    fullname: EN Billingslea
– volume: 32
  start-page: 13819
  year: 2012
  ident: 60_CR45
  publication-title: J Neurosci.
  doi: 10.1523/JNEUROSCI.2601-12.2012
  contributor:
    fullname: J Akerboom
– volume: 29
  start-page: 15595
  year: 2009
  ident: 60_CR25
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3864-09.2009
  contributor:
    fullname: WL Shew
– volume: 38
  start-page: 958
  year: 2012
  ident: 60_CR3
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sbs069
  contributor:
    fullname: DC Javitt
– volume: 9
  start-page: e99761
  year: 2014
  ident: 60_CR54
  publication-title: PLoS. ONE.
  doi: 10.1371/journal.pone.0099761
  contributor:
    fullname: S Yu
– volume: 34
  start-page: 2028
  year: 2009
  ident: 60_CR61
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2009.20
  contributor:
    fullname: HX Wang
– volume: 15
  start-page: 769
  year: 2012
  ident: 60_CR63
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3077
  contributor:
    fullname: S Royer
– volume: 169
  start-page: 220
  year: 2009
  ident: 60_CR15
  publication-title: Psychiatry. Res.
  doi: 10.1016/j.psychres.2008.06.032
  contributor:
    fullname: EM Sanchez-Morla
– volume: 23
  start-page: 11167
  year: 2003
  ident: 60_CR23
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.23-35-11167.2003
  contributor:
    fullname: JM Beggs
– volume: 13
  start-page: 1369
  year: 2003
  ident: 60_CR29
  publication-title: Cereb. Cortex.
  doi: 10.1093/cercor/bhg084
  contributor:
    fullname: MW Howard
– volume: 19
  start-page: 30
  year: 2014
  ident: 60_CR8
  publication-title: Mol. Psychiatr.
  doi: 10.1038/mp.2013.152
  contributor:
    fullname: JR Glausier
– volume: 61
  start-page: 900
  year: 1989
  ident: 60_CR48
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.1989.61.5.900
  contributor:
    fullname: A Aertsen
– volume: 29
  start-page: 1080
  year: 2004
  ident: 60_CR7
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1300394
  contributor:
    fullname: JD Andersen
– volume: 106
  start-page: 1279
  year: 2009
  ident: 60_CR76
  publication-title: Proc Natl Acad Sci U S A.
  doi: 10.1073/pnas.0809141106
  contributor:
    fullname: S Whitfield-Gabrieli
– volume: 205
  start-page: 259
  year: 2012
  ident: 60_CR22
  publication-title: Eur Phy J Special Topics.
  doi: 10.1140/epjst/e2012-01575-5
  contributor:
    fullname: D Plenz
– volume: 101
  start-page: 10554
  year: 2004
  ident: 60_CR42
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0400417101
  contributor:
    fullname: T Nagai
– volume: 77
  start-page: 52
  year: 2015
  ident: 60_CR4
  publication-title: Biol. Psychiatr.
  doi: 10.1016/j.biopsych.2014.07.011
  contributor:
    fullname: J Hall
– volume: 104
  start-page: 3691
  year: 2010
  ident: 60_CR46
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.01073.2009
  contributor:
    fullname: JT Vogelstein
– volume: 324
  start-page: 354
  year: 2009
  ident: 60_CR44
  publication-title: Science
  doi: 10.1126/science.1167093
  contributor:
    fullname: V Gradinaru
– volume: S2211-1247
  start-page: 30334
  year: 2016
  ident: 60_CR58
  publication-title: Cell Rep.
  contributor:
    fullname: S Sachidhanandam
– volume: 39
  start-page: 120
  year: 2013
  ident: 60_CR72
  publication-title: Schizophr. Bull.
  doi: 10.1093/schbul/sbr069
  contributor:
    fullname: A Marsman
– volume: 33
  start-page: 17363
  year: 2013
  ident: 60_CR39
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1516-13.2013
  contributor:
    fullname: C Meisel
– volume: 2
  year: 2012
  ident: 60_CR40
  publication-title: Transl Psychiatr.
  doi: 10.1038/tp.2012.69
  contributor:
    fullname: MJ Gandal
– volume: 35
  start-page: 1349
  year: 2011
  ident: 60_CR14
  publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatr.
  doi: 10.1016/j.pnpbp.2011.04.009
  contributor:
    fullname: VA Diwadkar
– ident: 60_CR19
  doi: 10.1016/j.neuron.2017.03.019
– volume: 30
  start-page: 44
  year: 2015
  ident: 60_CR16
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2014.08.006
  contributor:
    fullname: A Fornito
– volume: 27
  start-page: 380
  year: 2010
  ident: 60_CR65
  publication-title: J Clin Neurophysiol
  doi: 10.1097/WNP.0b013e3181fdf8d3
  contributor:
    fullname: JP Hobbs
– volume: 14
  start-page: 477
  year: 1995
  ident: 60_CR49
  publication-title: Neuron.
  doi: 10.1016/0896-6273(95)90304-6
  contributor:
    fullname: PS Goldman-Rakic
– volume: 56
  start-page: 33
  year: 2007
  ident: 60_CR60
  publication-title: Neuron.
  doi: 10.1016/j.neuron.2007.09.012
  contributor:
    fullname: TF Freund
– volume: 24
  start-page: 859
  year: 2014
  ident: 60_CR66
  publication-title: Cereb. Cortex.
  doi: 10.1093/cercor/bhs370
  contributor:
    fullname: JD Murray
– volume: 477
  start-page: 171
  year: 2011
  ident: 60_CR43
  publication-title: Nature.
  doi: 10.1038/nature10360
  contributor:
    fullname: O Yizhar
– volume: 33
  start-page: 17363
  year: 2013
  ident: 60_CR33
  publication-title: J Neurosci.
  doi: 10.1523/JNEUROSCI.1516-13.2013
  contributor:
    fullname: C Meisel
– volume: 106
  start-page: 15921
  year: 2009
  ident: 60_CR32
  publication-title: Proc Natl Acad Sci U S A.
  doi: 10.1073/pnas.0904089106
  contributor:
    fullname: T Petermann
– volume: 10
  start-page: 376
  year: 2007
  ident: 60_CR30
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn1846
  contributor:
    fullname: S Vijayraghavan
– volume: 90
  start-page: 128
  year: 2016
  ident: 60_CR67
  publication-title: Neuron.
  doi: 10.1016/j.neuron.2016.02.009
  contributor:
    fullname: K Rajan
– volume: 171
  start-page: 799
  year: 2014
  ident: 60_CR13
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.12518
  contributor:
    fullname: PS Suryavanshi
– volume: 388
  start-page: 86
  year: 2016
  ident: 60_CR2
  publication-title: Lancet.
  doi: 10.1016/S0140-6736(15)01121-6
  contributor:
    fullname: MJ Owen
SSID ssj0000548171
Score 2.3261793
Snippet Disturbed activity patterns in cortical networks contribute to the pathophysiology of schizophrenia (SZ). Several lines of evidence implicate NMDA receptor...
SourceID pubmedcentral
proquest
crossref
pubmed
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 3
SubjectTerms 631/378
631/443
Animals
Antagonist drugs
Behavioral Sciences
Biological Psychology
Cognitive ability
Cognitive Dysfunction - chemically induced
Cognitive Dysfunction - metabolism
Excitatory Amino Acid Antagonists - toxicity
Female
GABA-B Receptor Agonists - pharmacology
Interneurons - metabolism
Medicine
Medicine & Public Health
Memory, Short-Term - drug effects
Memory, Short-Term - physiology
Neurosciences
Pharmacotherapy
Psychiatry
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate - metabolism
Rodents
Schizophrenia - chemically induced
Schizophrenia - metabolism
Signal Transduction - drug effects
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB5RkKpeUFv6SEsrI_VEZbGOE9s5VSsoQpWWAyrSnogcP8Reki27IJVf35m8YIvaSy52Hp6ZeL7xvAC-KB2MLvyE-yyPPDOF4tUk5lykPupgUYd4Sk6enauzy-zHPJ_3B26rPqxy2BPbjdo3js7Ij9A4VmlbYO7b8henrlHkXe1baDyDHZGiKkd51nM9nrEgHDFCi8GZKc3RCvdsyinDrZkqkfD7TXX0BGM-DZX8y1_aqqHTl7Db40c27Rj-CrZC_Rqez3oP-R5cTcn9HTyzdxS0iCxhvms6v2KLmlnmH6KE8Dnns5PpBbv-vWxIwRGTWNsbhzWRjZFFjFIpFzd0yxu4PP3-8_iM9z0UuMulWnPljTWplFmlXRRqEhEfhNxYqyuBpkQ6cTbL8CKcDl54pFdU0Rlp0cjW0qXyLWzXTR3eA6usEFbZgrJvUYtpnJqlTrvKRVngIxM4HEhZLrtSGWXr4pam7OheIt1Lont5n8D-QOyy_2tW5QOPEzgYh1HeyYlh69DctnOKHM0qmSbwruPN-DaELoIcjQnoDa6NE6iW9uZIvbhua2rnBsFKlifwdeDvo8_61yI-_H8RH-EFwiuSNlR2-7C9vrkNnxDCrKvPrZz-AR0c8Jk
  priority: 102
  providerName: ProQuest
– databaseName: SpringerOpen
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9swDCa6FCh2Gba127xlhQrs1MJoZNmSfAzSFsGA5FAsQE81ZD3QXJwijwHLrx9pO97SbodefBEl2yQtkv5ICuCbVF6r3A1il2YhTnUu43IQspgnLihv0IY4Kk6eTOV4ln6_y-7aZtFUC7OH3wt9ucJNlorAcC-l1iHx9hUcoglWpMwjOep-p6DnobniO9zyXzP3Lc8zd_J5VuQTaLS2ODdv4U3rKrJhI9t3cOCr93A0acHwY7gfEtLtHTM_KT8Ruc9cc778is0rZpj7kxCE60wnV8Nb9vDrcUG2jOTB6mNw2CKwLomIUdXkfElTTmB2c_1jNI7b4xJimwm5jqXTRidCpKWygctBQFfAZ9oYVXKMGpKBNWmKF26Vd9whv4IMVguD8bQSNhEfoFctKv8JWGk4N9LkVGiLBkshaZpYZUsbRI5LRnC-Y2Xx2HTFKGo0W-ii4XuBfC-I78U2gv6O2UX7gawKnmMoVfcLjOCsG0bVJrzCVH6xqWnyDCMokUTwsZFNdzf0UjhhihGoPal1BNQ2e3-kmj_U7bMzjX5JmkVwsZPvX4_1v5f4_CLqL_AaHStSPjRzfeitlxv_FZ2XdXlaq-1vsNDppw
  priority: 102
  providerName: Springer Nature
Title Altered avalanche dynamics in a developmental NMDAR hypofunction model of cognitive impairment
URI https://link.springer.com/article/10.1038/s41398-017-0060-z
https://www.ncbi.nlm.nih.gov/pubmed/29317600
https://www.proquest.com/docview/1986200371
https://search.proquest.com/docview/1989555032
https://pubmed.ncbi.nlm.nih.gov/PMC5802445
Volume 8
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFD60HYy9jN3nrQsa7GnDTWRd_ehlLSWQULoV8jQjSxYNrE5o0sH663ck21m6spe92GDJsq3v2N85PhcBfJCq1ip3o9Rx4VOuc5lWIy9SmjmvaoMc4kJy8nQmTy_4ZC7meyD6XJgYtG-rxVHz4-qoWVzG2MrVlR32cWLDs-lYaGQWLob7sI_0u2OitwW9uaaK9h5Mpodr_FCHRDL8HofyI-ltqACcI3HKkNe2S0f3dMz7oZJ_-UsjDZ08gced_kiK9j6fwl7dPIOH085D_hy-F8H9XTtifoagRYSEuHbR-TVZNMQQ9ydKCMeZTb8U5-Ty12oZCC6AROLaOGTpyTayiIRUysV1OOUFXJwcfxufpt0aCqkVTG5S6bTRGWO8UtZTOfKoH9RCG6MqiqZENrKGc9xQq2pHHU6dl95qZtDIVsxm7CUcNMumfg2kMpQaafKQfYssprArz6yylfUsxyET-NhPZblqS2WU0cXNdNlCUCIEZYCgvE3gsJ_ssntr1iXN0b6KRQQTeL9tRnkPTgzT1Mub2CcXaFaxLIFXLTbbq_WgJqDuoLbtEGpp321BEYs1tTuRSuBTj-_Obf3rId7893XewiPUvIJMIg8ewsHm-qZ-h9rNphqgTM_VAB4UxeTrBPefj2dn53h0LMeD-MdgEOX9N8Jp_3Q
link.rule.ids 230,314,727,780,784,864,885,12056,21388,27924,27925,31719,31720,33744,33745,41120,42189,43310,43805,51576,53791,53793,73745,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVgIuFW9CCxiJEyjqOk5s54QWaLVAd4WqVuqJyPFD3UuydLdI7a_vTF5lqeCSi52HZ5yZbzwvgHdSea1yN45dmoU41bmMy3HIYp64oLxBHeIoOXk2l9OT9NtpdtoduK26sMpeJjaC2tWWzsj30DiWSVNg7uPyV0xdo8i72rXQuAtbVDk9G8HWp_35j6PhlAUBieaK9-5MofdWKLUpqwyFM9Uiia82FdItlHk7WPIvj2mjiA4ewnaHINmkZfkjuOOrx3Bv1vnIn8DPCTnAvWPmN4UtIlOYa9vOr9iiYoa5mzghfM589mVyxM4ulzWpOGITa7rjsDqwIbaIUTLl4pxueQonB_vHn6dx10UhtpmQ61g6bXQiRFoqG7gcB0QIPtPGqJKjMZGMrUlTvHCrvOMO6RVksFoYNLOVsIl4BqOqrvwLYKXh3EiTU_4t6jGFU9PEKlvaIHJ8ZATve1IWy7ZYRtE4uYUuWroXSPeC6F5cRbDbE7vo_ptVccPlCN4Ow7jjyY1hKl9fNHPyDA0rkUTwvOXN8DYEL5xcjRGoDa4NE6ia9uZItThrqmpnGuFKmkXwoefvH5_1r0W8_P8i3sD96fHssDj8Ov--Aw8QbNHOQ9W3C6P1-YV_hYBmXb7udu01r_H07w
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVqq4IMozUMBInEDWxnFiO6dqabsqj11VFZV6InLsWN1LsnS3ldpf33HipCwVXHKx8_DMxPON5wXwUchKydzG1KaZo6nKBS1jl1GWWCcrjTrE-uTk2VwcnabfzrKzEP-0CmGV_Z7YbtS2Mf6MfIzGsUjaAnNjF8Iijg-me8vf1HeQ8p7W0E7jIWyhVoyTEWx9OZwfnwwnLghOFJOsd21yNV7hDu4zzHCj9nVJ6M2mcrqHOO8HTv7lPW2V0vQJPA5okkw69u_Ag6p-Ctuz4C9_Br8m3hleWaKvfAgjMojYrgX9iixqoom9ixnC58xnB5MTcn69bLy68ywjbacc0jgyxBkRn1i5uPC3PIfT6eHP_SMaOipQk3GxpsIqrRLO01Iax0TsEC1UmdJalgwNiyQ2Ok3xwoysLLNILyecUVyjyS25SfgLGNVNXb0CUmrGtNC5z8VFnSZxapoYaUrjeI6PjOBTT8pi2RXOKFqHN1dFR_cC6V54uhc3Eez2xC7CP7Qq7jgewYdhGKXfuzR0XTWX7Zw8QyOLJxG87HgzvA2BDPNuxwjkBteGCb6y9uZIvThvK2xnCqFLmkXwuefvH5_1r0W8_v8i3sM2Cmzx4-v8-xt4hLjLCx5qwV0YrS8uq7eIbdbluyC0twV4-Rw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Altered+avalanche+dynamics+in+a+developmental+NMDAR+hypofunction+model+of+cognitive+impairment&rft.jtitle=Translational+psychiatry&rft.au=Seshadri%2C+Saurav&rft.au=Klaus%2C+Andreas&rft.au=Winkowski%2C+Daniel+E.&rft.au=Kanold%2C+Patrick+O.&rft.date=2018-01-10&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2158-3188&rft.volume=8&rft_id=info:doi/10.1038%2Fs41398-017-0060-z&rft_id=info%3Apmid%2F29317600&rft.externalDBID=PMC5802445
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2158-3188&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2158-3188&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2158-3188&client=summon