The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB

• Published in: Nature immunology Vol. 13; no. 9; pp. 823 - 831
• Main Authors: Schneider, Monika, Zimmermann, Albert G, Roberts, Reid A, Zhang, Lu, Swanson, Karen V, Wen, Haitao, Davis, Beckley K, Allen, Irving C, Holl, Eda K, Ye, Zhengmao, Rahman, Adeeb H, Conti, Brian J, Eitas, Timothy K, Koller, Beverly H, Ting, Jenny P-Y
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.09.2012; Nature Publishing Group
• Subjects: 631/1647/48; 631/250/2502; 631/250/256; 631/250/516; Amino Acid Sequence; Animals; Biomedical and Life Sciences; Biomedicine; Cytokines; Feedback, Physiological; HEK293 Cells; Humans; Immunology; Infectious Diseases; Macrophages - immunology; Macrophages - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; NF-kappa B - immunology; NF-kappa B - metabolism; Physiological aspects; Real-Time Polymerase Chain Reaction; Receptors, G-Protein-Coupled - immunology; Receptors, G-Protein-Coupled - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction - immunology; TNF Receptor-Associated Factor 6 - immunology; TNF Receptor-Associated Factor 6 - metabolism; Toll-like receptors; Toll-Like Receptors - immunology; Toll-Like Receptors - metabolism; Transcription factors; United States

Sensors of the NLR family generally activate innate immunity. Ting et al ., however, demonstrate that the little-known NLRC3 negatively regulates Toll-like receptor signaling by altering ubiquitination of the signaling adaptor TRAF6. Several members of the NLR family of sensors activate innate immun...