Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways - Papaleo, F; Yang, F; Garcia, S; Chen, J; Lu, B; Crawley, J N; Weinberger, D R (Molecular psychiatry, 2012)
Keywords: 631/378/1457/1945; 631/378/1689/1761; 631/92/436/2388; Action Potentials - drug effects; Action Potentials - genetics; Adult and adolescent clinical studies; Amphetamine - adverse effects; Animals; Behavior; Behavioral Sciences; Binding proteins; Biological and medical sciences; Biological Psychology; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism; Carrier Proteins - genetics; Cognition & reasoning; Cognitive ability; Disease Models, Animal; Dopamine; Dopamine - metabolism; Dopamine Agents - pharmacology; Dopaminergic mechanisms; Dysbindin; Dystrophin-Associated Proteins; Gene Expression Regulation, Enzymologic - drug effects; Gene Expression Regulation, Enzymologic - genetics; Genes; Genetic aspects; Genetic engineering; Genetic regulation; Hyperkinesis - drug therapy; Hyperkinesis - etiology; Hyperkinesis - genetics; Kinases; Maze Learning - drug effects; Medical sciences; Medicine; Medicine & Public Health; Memory; Memory Disorders - drug therapy; Memory Disorders - etiology; Memory, Short-Term - drug effects; Memory, Short-Term - physiology; Mental health; Mice; Mice, Inbred DBA; Mice, Knockout; Motor Activity - drug effects; Motor Activity - genetics; Mutation; Neurosciences; original-article; Pharmacotherapy; Prefrontal cortex; Prefrontal Cortex - drug effects; Prefrontal Cortex - pathology; Prefrontal Cortex - physiopathology; Properties; Protein expression; Proteins; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychosis; Pyramidal Cells - drug effects; Reaction Time - drug effects; Reaction Time - genetics; Receptors, Dopamine D2 - metabolism; Schizophrenia; Schizophrenia - complications; Schizophrenia - pathology; Sensory Gating - drug effects; Sensory Gating - genetics; Stress, Psychological - physiopathology; United States; United States--US; Italy; schizophrenia; genes; working memory; dopamine; mice; prefrontal cortex; Cerebral cortex; Dopamine; Rodentia; Central nervous system; Schizophrenia; Cognition; Prefrontal cortex; Catecholamine; Genetic determinism; Encephalon; Psychosis; Vertebrata; Mammalia; Gene; Mouse; Animal