Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways

Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys−/−) (1) schizophrenia-related behavi...

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Published inMolecular psychiatry Vol. 17; no. 1; pp. 85 - 98
Main Authors Papaleo, F, Yang, F, Garcia, S, Chen, J, Lu, B, Crawley, J N, Weinberger, D R
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.01.2012
Nature Publishing Group
Subjects
631/378/1457/1945
631/378/1689/1761
631/92/436/2388
Action Potentials - drug effects
Action Potentials - genetics
Adult and adolescent clinical studies
Amphetamine - adverse effects
Animals
Behavior
Behavioral Sciences
Binding proteins
Biological and medical sciences
Biological Psychology
Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism
Carrier Proteins - genetics
Cognition & reasoning
Cognitive ability
Disease Models, Animal
Dopamine
Dopamine - metabolism
Dopamine Agents - pharmacology
Dopaminergic mechanisms
Dysbindin
Dystrophin-Associated Proteins
Gene Expression Regulation, Enzymologic - drug effects
Gene Expression Regulation, Enzymologic - genetics
Genes
Genetic aspects
Genetic engineering
Genetic regulation
Hyperkinesis - drug therapy
Hyperkinesis - etiology
Hyperkinesis - genetics
Kinases
Maze Learning - drug effects
Medical sciences
Medicine
Medicine & Public Health
Memory
Memory Disorders - drug therapy
Memory Disorders - etiology
Memory, Short-Term - drug effects
Memory, Short-Term - physiology
Mental health
Mice
Mice, Inbred DBA
Mice, Knockout
Motor Activity - drug effects
Motor Activity - genetics
Mutation
Neurosciences
original-article
Pharmacotherapy
Prefrontal cortex
Prefrontal Cortex - drug effects
Prefrontal Cortex - pathology
Prefrontal Cortex - physiopathology
Properties
Protein expression
Proteins
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Psychosis
Pyramidal Cells - drug effects
Reaction Time - drug effects
Reaction Time - genetics
Receptors, Dopamine D2 - metabolism
Schizophrenia
Schizophrenia - complications
Schizophrenia - pathology
Sensory Gating - drug effects
Sensory Gating - genetics
Stress, Psychological - physiopathology
United States
United States > US
Italy
schizophrenia
genes
working memory
dopamine
mice
prefrontal cortex
Cerebral cortex
Dopamine
Rodentia
Central nervous system
Schizophrenia
Cognition
Prefrontal cortex
Catecholamine
Genetic determinism
Encephalon
Psychosis
Vertebrata
Mammalia
Gene
Mouse
Animal
Neurotransmitter
Genetics
Behavior
Working memory
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Abstract Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys−/−) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related behaviors and impaired working memory under challenging/stressful conditions. Dys−/− pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D2 stimulation. Dys−/− were also respectively more and less sensitive to D2 agonist- and antagonist-induced behavioral effects. Dys−/− had reduced expression of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and CaMKKβ in mPFC. Chronic D2 agonist treatment reproduced these changes in protein expression, and some of the dys−/− behavioral effects. These results elucidate dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis.
AbstractList Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys-/-) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related behaviors and impaired working memory under challenging/stressful conditions. Dys-/- pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D2 stimulation. Dys-/- were also respectively more and less sensitive to D2 agonist- and antagonist-induced behavioral effects. Dys-/- had reduced expression of [Ca.sup.2+]/calmodulin-dependent protein kinase II (CaMKII) and CaMKKβ in mPFC. Chronic D2 agonist treatment reproduced these changes in protein expression, and some of the dys-/- behavioral effects. These results elucidate dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis.
Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys-/-) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related behaviors and impaired working memory under challenging/stressful conditions. Dys-/- pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D2 stimulation. Dys-/- were also respectively more and less sensitive to D2 agonist- and antagonist-induced behavioral effects. Dys-/- had reduced expression of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and CaMKKβ in mPFC. Chronic D2 agonist treatment reproduced these changes in protein expression, and some of the dys-/- behavioral effects. These results elucidate dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis.Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys-/-) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related behaviors and impaired working memory under challenging/stressful conditions. Dys-/- pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D2 stimulation. Dys-/- were also respectively more and less sensitive to D2 agonist- and antagonist-induced behavioral effects. Dys-/- had reduced expression of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and CaMKKβ in mPFC. Chronic D2 agonist treatment reproduced these changes in protein expression, and some of the dys-/- behavioral effects. These results elucidate dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis.
Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys-/-) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related behaviors and impaired working memory under challenging/stressful conditions. Dys-/- pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D2 stimulation. Dys-/- were also respectively more and less sensitive to D2 agonist- and antagonist-induced behavioral effects. Dys-/- had reduced expression of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and CaMKKβ in mPFC. Chronic D2 agonist treatment reproduced these changes in protein expression, and some of the dys-/- behavioral effects. These results elucidate dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis.
Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys–/–) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related behaviors and impaired working memory under challenging/stressful conditions. Dys–/– pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D2 stimulation. Dys–/– were also respectively more and less sensitive to D2 agonist- and antagonist-induced behavioral effects. Dys–/– had reduced expression of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and CaMKKβ in mPFC. Chronic D2 agonist treatment reproduced these changes in protein expression, and some of the dys–/– behavioral effects. These results elucidate dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis.
Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys-/-) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related behaviors and impaired working memory under challenging/stressful conditions. Dys-/- pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D2 stimulation. Dys-/- were also respectively more and less sensitive to D2 agonist- and antagonist-induced behavioral effects. Dys-/- had reduced expression of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and CaMKK[beta] in mPFC. Chronic D2 agonist treatment reproduced these changes in protein expression, and some of the dys-/- behavioral effects. These results elucidate dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis.
Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys−/−) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related behaviors and impaired working memory under challenging/stressful conditions. Dys−/− pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D2 stimulation. Dys−/− were also respectively more and less sensitive to D2 agonist- and antagonist-induced behavioral effects. Dys−/− had reduced expression of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and CaMKKβ in mPFC. Chronic D2 agonist treatment reproduced these changes in protein expression, and some of the dys−/− behavioral effects. These results elucidate dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis.
Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys-/-) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related behaviors and impaired working memory under challenging/stressful conditions. Dys-/- pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D2 stimulation. Dys-/- were also respectively more and less sensitive to D2 agonist- and antagonist-induced behavioral effects. Dys-/- had reduced expression of [Ca.sup.2+]/calmodulin-dependent protein kinase II (CaMKII) and CaMKKβ in mPFC. Chronic D2 agonist treatment reproduced these changes in protein expression, and some of the dys-/- behavioral effects. These results elucidate dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis. Molecular Psychiatry (2012) 17, 85-98; doi: 10.1038/mp.2010.106; published online 19 October 2010 Keywords: dopamine; genes; mice; prefrontal cortex; schizophrenia; working memory
Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect mediates the clinical manifestations of the disorder is unknown. We explored in dysbindin-1-deficient mice (dys-/-) (1) schizophrenia-related behaviors, (2) molecular and electrophysiological changes in medial prefrontal cortex (mPFC) and (3) the dependence of these on D2-receptor stimulation. Dysbindin-1 disruption altered dopamine-related behaviors and impaired working memory under challenging/stressful conditions. Dys-/- pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D2 stimulation. Dys-/- were also respectively more and less sensitive to D2 agonist- and antagonist-induced behavioral effects. Dys-/- had reduced expression of Ca super(2+)/calmodulin-dependent protein kinase II (CaMKII) and CaMKK beta in mPFC. Chronic D2 agonist treatment reproduced these changes in protein expression, and some of the dys-/- behavioral effects. These results elucidate dysbindin's modulation of D2-related behavior, cortical activity and mPFC CaMK components, implicating cellular and molecular mechanisms of the association of dysbindin with psychosis.
Audience Academic
Author Papaleo, F
Lu, B
Chen, J
Crawley, J N
Garcia, S
Weinberger, D R
Yang, F
AuthorAffiliation 2 Department of Neuroscience and Brain Technologies, The Italian Institute of Technology, Genova, Italy
3 Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, Bethesda, MD, USA
4 Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, MD, USA
1 Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, MD, USA
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– name: 2 Department of Neuroscience and Brain Technologies, The Italian Institute of Technology, Genova, Italy
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– name: 3 Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, Bethesda, MD, USA
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  organization: Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health
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  organization: Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health
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  organization: Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health
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  surname: Crawley
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  organization: Laboratory of Behavioral Neuroscience, National Institute of Mental Health
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  surname: Weinberger
  fullname: Weinberger, D R
  email: weinberd@mail.nih.gov
  organization: Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health
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https://www.ncbi.nlm.nih.gov/pubmed/20956979$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.biopsych.2006.12.025
10.1016/S0006-3223(02)01316-1
10.1523/JNEUROSCI.1021-04.2004
10.1523/JNEUROSCI.23-03-00867.2003
10.1016/j.neuron.2008.12.015
10.1016/S0079-6123(00)26014-7
10.1007/s004220050292
10.1016/j.nlm.2008.05.015
10.1126/science.1091162
10.1016/0306-4522(94)90226-7
10.1523/JNEUROSCI.1689-07.2007
10.1038/sj.npp.1301003
10.1016/j.neuron.2006.01.023
10.1073/pnas.0904289106
10.1073/pnas.0910499106
10.1126/science.1179685
10.1016/j.neulet.2009.12.071
10.1016/j.bbrc.2006.04.163
10.1073/pnas.98.4.1964
10.1038/nrn1327
10.1016/j.schres.2007.05.041
10.1038/npp.2009.90
10.1016/j.neulet.2007.05.019
10.1073/pnas.0707106104
10.1046/j.1471-4159.2002.00967.x
10.1038/nn1846
10.1093/hmg/ddi481
10.1016/S0079-6123(09)17910-4
10.1016/j.jchemneu.2006.12.005
10.1097/FBP.0b013e32831c3b2b
10.1523/JNEUROSCI.23-30-09752.2003
10.1093/hmg/ddp329
10.1038/ng1229
10.1016/j.neuropsychologia.2006.06.016
10.1016/j.pneurobio.2004.05.006
10.1523/JNEUROSCI.2077-08.2008
10.1016/S0361-9230(99)00243-9
10.1038/sj.mp.4001159
10.1523/JNEUROSCI.20-22-08305.2000
10.1016/j.neuroscience.2006.06.027
10.1083/jcb.200711021
10.1093/cercor/bhn134
10.1016/S0166-4328(99)00166-7
10.1016/j.neuron.2006.09.023
10.1007/978-0-387-30410-6_5
10.1016/S0169-328X(98)00118-1
10.1086/341750
10.1086/345463
10.1001/archpsyc.61.6.544
10.1016/S0006-3223(01)01335-X
10.1172/JCI200420425
10.1001/archpsyc.61.4.336
10.1186/1756-6606-1-11
10.1016/j.bbr.2003.10.025
10.1007/s002130100810
10.1196/annals.1300.063
10.1111/j.1601-183X.2009.00477.x
10.1101/lm.89405
10.1016/S0301-0082(98)00098-7
10.1001/archpsyc.62.4.379
10.1007/s002130000668
10.1016/S1054-3589(08)60846-7
10.1016/S0006-8993(96)00945-6
10.1101/lm.7.3.170
10.1523/JNEUROSCI.21-10-03628.2001
ContentType Journal Article
Copyright Macmillan Publishers Limited 2012
2015 INIST-CNRS
COPYRIGHT 2012 Nature Publishing Group
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Copyright_xml – notice: Macmillan Publishers Limited 2012
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Issue 1
Keywords schizophrenia
genes
working memory
dopamine
mice
prefrontal cortex
Cerebral cortex
Dopamine
Rodentia
Central nervous system
Schizophrenia
Cognition
Prefrontal cortex
Catecholamine
Genetic determinism
Encephalon
Psychosis
Vertebrata
Mammalia
Gene
Mouse
Animal
Neurotransmitter
Genetics
Behavior
Working memory
Language English
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PublicationTitle Molecular psychiatry
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PublicationYear 2012
Publisher Nature Publishing Group UK
Nature Publishing Group
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References Burdick, Lencz, Funke, Finn, Szeszko, Kane (CR3) 2006; 15
Jentsch, Trantham-Davidson, Jairl, Tinsley, Cannon, Lavin (CR20) 2009; 34
Le Moine, Gaspar (CR54) 1998; 58
Peters, Mizuno, Ris, Angelo, Godaux, Giese (CR65) 2003; 23
Ford, Mathalon, Whitfield, Faustman, Roth (CR57) 2002; 51
Vijayraghavan, Wang, Birnbaum, Williams, Arnsten (CR35) 2007; 10
Zhang, Bertolino, Fazio, Blasi, Rampino, Romano (CR47) 2007; 104
Plappert, Pilz, Schnitzler (CR61) 2004; 152
Chen, Feng, Hao, Guo, He, Zhou (CR2) 2008; 181
Hess, Jacobs, Donoghue (CR42) 1994; 61
Feenstra, Botterblom (CR38) 1996; 742
Morris, Murphy, Kenny, Purcell, McGhee, Schwaiger (CR5) 2008; 63
Arnsten (CR37) 2000; 126
Arguello, Gogos (CR41) 2006; 52
Lawrie, Buechel, Whalley, Frith, Friston, Johnstone (CR56) 2002; 51
Turrigiano, Nelson (CR51) 2004; 5
Li, Zhang, Oiso, Novak, Gautam, O'Brien (CR18) 2003; 35
Santana, Mengod, Artigas (CR50) 2009; 19
Iizuka, Sei, Weinberger, Straub (CR13) 2007; 27
Nguyen, Abel, Kandel, Bourtchouladze (CR32) 2000; 7
Kumamoto, Matsuzaki, Inoue, Hattori, Shimizu, Hashimoto (CR17) 2006; 345
Nagai, Kitahara, Shiraki, Hikita, Taya, Kaibuchi (CR49) 2010; 470
Seamans, Yang (CR53) 2004; 74
Chausmer, Katz (CR62) 2001; 155
Ji, Yang, Papaleo, Wang, Gao, Weinberger (CR14) 2009; 106
Takeuchi, Fukunaga, Miyamoto (CR28) 2002; 82
Wang, Xu, Sasaoka, Tonegawa, Kung, Sankoorikal (CR63) 2000; 20
Murotani, Ishizuka, Hattori, Hashimoto, Matsuzaki, Yamatodani (CR19) 2007; 421
Liu, Mao, Zhang, Papasian, Fibuch, Lan (CR26) 2009; 61
Papaleo, Crawley, Song, Lipska, Pickel, Weinberger (CR27) 2008; 28
Straub, Jiang, MacLean, Ma, Webb, Myakishev (CR7) 2002; 71
Tang, Yang, Chen, Lu, Ji, Roche (CR22) 2009; 106
Wang, Vijayraghavan, Goldman-Rakic (CR46) 2004; 303
Khan, Koulen, Rubinstein, Grandy, Goldman-Rakic (CR64) 2001; 98
Laruelle, Kegeles, Abi-Dargham (CR15) 2003; 1003
Talbot, Ong, Blake, Tang, Louneva, Carlson (CR1) 2009
Weickert, Rothmond, Hyde, Kleinman, Straub (CR9) 2008; 98
Vertes (CR34) 2006; 142
Halberstadt, Geyer (CR60) 2009; 92
D'Este, Casini, Puglisi-Allegra, Cabib, Renda (CR29) 2007; 33
Talbot, Eidem, Tinsley, Benson, Thompson, Smith (CR8) 2004; 113
Braff, Geyer, Swerdlow (CR40) 2001; 156
Weickert, Straub, McClintock, Matsumoto, Hashimoto, Hyde (CR10) 2004; 61
Meyer-Lindenberg, Olsen, Kohn, Brown, Egan, Weinberger (CR55) 2005; 62
Miller (CR43) 1996; 75
Runyan, Moore, Dash (CR24) 2005; 12
Tseng, O'Donnell (CR45) 2004; 24
Geyer, McIlwain, Paylor (CR58) 2002; 7
Cox, Tucker, Tang, Talbot, Richer, Yeh (CR31) 2009; 8
Druzin, Kurzina, Malinina, Kozlov (CR48) 2000; 109
Lewis, Gonzalez-Burgos (CR44) 2000; 52
Weber, Chang, Breier, Ko, Swerdlow (CR59) 2008; 19
Williams, Preece, Morris, Spurlock, Bray, Stephens (CR12) 2004; 61
Dickman, Davis (CR21) 2009; 326
Koch (CR39) 1999; 59
Seamans, Gorelova, Durstewitz, Yang (CR52) 2001; 21
Goldman-Rakic (CR16) 1998; 42
Talbot (CR23) 2009; 179
Fallgatter, Herrmann, Hohoff, Ehlis, Jarczok, Freitag (CR4) 2006; 31
Donohoe, Morris, Clarke, McGhee, Schwaiger, Nangle (CR36) 2007; 45
Schwab, Knapp, Mondabon, Hallmayer, Borrmann-Hassenbach, Albus (CR6) 2003; 72
Gonzalez-Islas, Hablitz (CR25) 2003; 23
Takao, Toyama, Nakanishi, Hattori, Takamura, Takeda (CR30) 2008; 1
Kellendonk, Simpson, Polan, Malleret, Vronskaya, Winiger (CR33) 2006; 49
Tang, LeGros, Louneva, Yeh, Cohen, Hahn (CR11) 2009; 18
NM Williams (BFmp2010106_CR12) 2004; 61
JD Jentsch (BFmp2010106_CR20) 2009; 34
KE Burdick (BFmp2010106_CR3) 2006; 15
M Peters (BFmp2010106_CR65) 2003; 23
R Miller (BFmp2010106_CR43) 1996; 75
JM Ford (BFmp2010106_CR57) 2002; 51
Y Wang (BFmp2010106_CR63) 2000; 20
CF Plappert (BFmp2010106_CR61) 2004; 152
T Nagai (BFmp2010106_CR49) 2010; 470
AJ Fallgatter (BFmp2010106_CR4) 2006; 31
Y Iizuka (BFmp2010106_CR13) 2007; 27
PS Goldman-Rakic (BFmp2010106_CR16) 1998; 42
RP Vertes (BFmp2010106_CR34) 2006; 142
SG Schwab (BFmp2010106_CR6) 2003; 72
MM Cox (BFmp2010106_CR31) 2009; 8
JK Seamans (BFmp2010106_CR53) 2004; 74
Y Zhang (BFmp2010106_CR47) 2007; 104
K Talbot (BFmp2010106_CR1) 2009
PA Arguello (BFmp2010106_CR41) 2006; 52
K Takao (BFmp2010106_CR30) 2008; 1
M Koch (BFmp2010106_CR39) 1999; 59
CS Weickert (BFmp2010106_CR9) 2008; 98
AS Meyer-Lindenberg (BFmp2010106_CR55) 2005; 62
CS Weickert (BFmp2010106_CR10) 2004; 61
PV Nguyen (BFmp2010106_CR32) 2000; 7
MA Geyer (BFmp2010106_CR58) 2002; 7
JK Seamans (BFmp2010106_CR52) 2001; 21
DA Lewis (BFmp2010106_CR44) 2000; 52
XY Liu (BFmp2010106_CR26) 2009; 61
ZU Khan (BFmp2010106_CR64) 2001; 98
Y Takeuchi (BFmp2010106_CR28) 2002; 82
N Kumamoto (BFmp2010106_CR17) 2006; 345
MG Feenstra (BFmp2010106_CR38) 1996; 742
N Santana (BFmp2010106_CR50) 2009; 19
T Murotani (BFmp2010106_CR19) 2007; 421
J Tang (BFmp2010106_CR11) 2009; 18
KY Tseng (BFmp2010106_CR45) 2004; 24
M Weber (BFmp2010106_CR59) 2008; 19
DL Braff (BFmp2010106_CR40) 2001; 156
JD Runyan (BFmp2010106_CR24) 2005; 12
AL Halberstadt (BFmp2010106_CR60) 2009; 92
GG Turrigiano (BFmp2010106_CR51) 2004; 5
SM Lawrie (BFmp2010106_CR56) 2002; 51
F Papaleo (BFmp2010106_CR27) 2008; 28
G Donohoe (BFmp2010106_CR36) 2007; 45
RE Straub (BFmp2010106_CR7) 2002; 71
DK Dickman (BFmp2010106_CR21) 2009; 326
MY Druzin (BFmp2010106_CR48) 2000; 109
W Li (BFmp2010106_CR18) 2003; 35
S Vijayraghavan (BFmp2010106_CR35) 2007; 10
C Kellendonk (BFmp2010106_CR33) 2006; 49
M Laruelle (BFmp2010106_CR15) 2003; 1003
C Gonzalez-Islas (BFmp2010106_CR25) 2003; 23
AF Arnsten (BFmp2010106_CR37) 2000; 126
XW Chen (BFmp2010106_CR2) 2008; 181
C Le Moine (BFmp2010106_CR54) 1998; 58
M Wang (BFmp2010106_CR46) 2004; 303
K Talbot (BFmp2010106_CR23) 2009; 179
DW Morris (BFmp2010106_CR5) 2008; 63
G Hess (BFmp2010106_CR42) 1994; 61
Y Ji (BFmp2010106_CR14) 2009; 106
L D'Este (BFmp2010106_CR29) 2007; 33
TT Tang (BFmp2010106_CR22) 2009; 106
AL Chausmer (BFmp2010106_CR62) 2001; 155
K Talbot (BFmp2010106_CR8) 2004; 113
References_xml – volume: 63
  start-page: 24
  year: 2008
  end-page: 31
  ident: CR5
  article-title: Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2006.12.025
– volume: 51
  start-page: 1008
  year: 2002
  end-page: 1011
  ident: CR56
  article-title: Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
  publication-title: Biol Psychiatry
  doi: 10.1016/S0006-3223(02)01316-1
– volume: 24
  start-page: 5131
  year: 2004
  end-page: 5139
  ident: CR45
  article-title: Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1021-04.2004
– volume: 23
  start-page: 867
  year: 2003
  end-page: 875
  ident: CR25
  article-title: Dopamine enhances EPSCs in layer II-III pyramidal neurons in rat prefrontal cortex
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.23-03-00867.2003
– volume: 61
  start-page: 425
  year: 2009
  end-page: 438
  ident: CR26
  article-title: Activity-dependent modulation of limbic dopamine D3 receptors by CaMKII
  publication-title: Neuron
  doi: 10.1016/j.neuron.2008.12.015
– volume: 126
  start-page: 183
  year: 2000
  end-page: 192
  ident: CR37
  article-title: Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine alpha-1 receptor mechanisms
  publication-title: Prog Brain Res
  doi: 10.1016/S0079-6123(00)26014-7
– volume: 75
  start-page: 253
  year: 1996
  end-page: 261
  ident: CR43
  article-title: Neural assemblies and laminar interactions in the cerebral cortex
  publication-title: Biol Cybern
  doi: 10.1007/s004220050292
– volume: 92
  start-page: 243
  year: 2009
  end-page: 248
  ident: CR60
  article-title: Habituation and sensitization of acoustic startle: opposite influences of dopamine D1 and D2-family receptors
  publication-title: Neurobiol Learn Mem
  doi: 10.1016/j.nlm.2008.05.015
– volume: 303
  start-page: 853
  year: 2004
  end-page: 856
  ident: CR46
  article-title: Selective D2 receptor actions on the functional circuitry of working memory
  publication-title: Science
  doi: 10.1126/science.1091162
– volume: 61
  start-page: 225
  year: 1994
  end-page: 235
  ident: CR42
  article-title: N-methyl-D-aspartate receptor mediated component of field potentials evoked in horizontal pathways of rat motor cortex
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(94)90226-7
– volume: 27
  start-page: 12390
  year: 2007
  end-page: 12395
  ident: CR13
  article-title: Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1689-07.2007
– volume: 31
  start-page: 2002
  year: 2006
  end-page: 2010
  ident: CR4
  article-title: DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in healthy individuals
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1301003
– volume: 49
  start-page: 603
  year: 2006
  end-page: 615
  ident: CR33
  article-title: Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning
  publication-title: Neuron
  doi: 10.1016/j.neuron.2006.01.023
– volume: 106
  start-page: 19593
  year: 2009
  end-page: 19598
  ident: CR14
  article-title: Role of dysbindin in dopamine receptor trafficking and cortical GABA function
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0904289106
– volume: 106
  start-page: 21395
  year: 2009
  end-page: 21400
  ident: CR22
  article-title: Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0910499106
– volume: 326
  start-page: 1127
  year: 2009
  end-page: 1130
  ident: CR21
  article-title: The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
  publication-title: Science
  doi: 10.1126/science.1179685
– volume: 470
  start-page: 134
  year: 2010
  end-page: 138
  ident: CR49
  article-title: Dysfunction of dopamine release in the prefrontal cortex of dysbindin deficient sandy mice: an microdialysis study
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2009.12.071
– volume: 345
  start-page: 904
  year: 2006
  end-page: 909
  ident: CR17
  article-title: Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2006.04.163
– volume: 98
  start-page: 1964
  year: 2001
  end-page: 1969
  ident: CR64
  article-title: An astroglia-linked dopamine D2-receptor action in prefrontal cortex
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.98.4.1964
– volume: 5
  start-page: 97
  year: 2004
  end-page: 107
  ident: CR51
  article-title: Homeostatic plasticity in the developing nervous system
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn1327
– volume: 98
  start-page: 105
  year: 2008
  end-page: 110
  ident: CR9
  article-title: Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2007.05.041
– volume: 34
  start-page: 2601
  year: 2009
  end-page: 2608
  ident: CR20
  article-title: Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2009.90
– volume: 421
  start-page: 47
  year: 2007
  end-page: 51
  ident: CR19
  article-title: High dopamine turnover in the brains of Sandy mice
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2007.05.019
– volume: 104
  start-page: 20552
  year: 2007
  end-page: 20557
  ident: CR47
  article-title: Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0707106104
– volume: 82
  start-page: 316
  year: 2002
  end-page: 328
  ident: CR28
  article-title: Activation of nuclear Ca(2+)/calmodulin-dependent protein kinase II and brain-derived neurotrophic factor gene expression by stimulation of dopamine D2 receptor in transfected NG108-15 cells
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.2002.00967.x
– volume: 10
  start-page: 376
  year: 2007
  end-page: 384
  ident: CR35
  article-title: Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
  publication-title: Nat Neurosci
  doi: 10.1038/nn1846
– volume: 15
  start-page: 1563
  year: 2006
  end-page: 1568
  ident: CR3
  article-title: Genetic variation in DTNBP1 influences general cognitive ability
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddi481
– volume: 179
  start-page: 87
  year: 2009
  end-page: 94
  ident: CR23
  article-title: The sandy (sdy) mouse: a dysbindin-1 mutant relevant to schizophrenia research
  publication-title: Prog Brain Res
  doi: 10.1016/S0079-6123(09)17910-4
– volume: 33
  start-page: 67
  year: 2007
  end-page: 74
  ident: CR29
  article-title: Comparative immunohistochemical study of the dopaminergic systems in two inbred mouse strains (C57BL/6J and DBA/2J)
  publication-title: J Chem Neuroanat
  doi: 10.1016/j.jchemneu.2006.12.005
– volume: 19
  start-page: 786
  year: 2008
  end-page: 795
  ident: CR59
  article-title: Heritable strain differences in sensitivity to the startle gating-disruptive effects of D2 but not D3 receptor stimulation
  publication-title: Behav Pharmacol
  doi: 10.1097/FBP.0b013e32831c3b2b
– volume: 23
  start-page: 9752
  year: 2003
  end-page: 9760
  ident: CR65
  article-title: Loss of Ca2+/calmodulin kinase kinase beta affects the formation of some, but not all, types of hippocampus-dependent long-term memory
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.23-30-09752.2003
– volume: 18
  start-page: 3851
  year: 2009
  end-page: 3863
  ident: CR11
  article-title: Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddp329
– volume: 35
  start-page: 84
  year: 2003
  end-page: 89
  ident: CR18
  article-title: Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)
  publication-title: Nat Genet
  doi: 10.1038/ng1229
– volume: 45
  start-page: 454
  year: 2007
  end-page: 458
  ident: CR36
  article-title: Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study
  publication-title: Neuropsychologia
  doi: 10.1016/j.neuropsychologia.2006.06.016
– volume: 74
  start-page: 1
  year: 2004
  end-page: 58
  ident: CR53
  article-title: The principal features and mechanisms of dopamine modulation in the prefrontal cortex
  publication-title: Prog Neurobiol
  doi: 10.1016/j.pneurobio.2004.05.006
– volume: 28
  start-page: 8709
  year: 2008
  end-page: 8723
  ident: CR27
  article-title: Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2077-08.2008
– volume: 52
  start-page: 309
  year: 2000
  end-page: 317
  ident: CR44
  article-title: Intrinsic excitatory connections in the prefrontal cortex and the pathophysiology of schizophrenia
  publication-title: Brain Res Bull
  doi: 10.1016/S0361-9230(99)00243-9
– volume: 7
  start-page: 1039
  year: 2002
  end-page: 1053
  ident: CR58
  article-title: Mouse genetic models for prepulse inhibition: an early review
  publication-title: Mol Psychiatry
  doi: 10.1038/sj.mp.4001159
– volume: 20
  start-page: 8305
  year: 2000
  end-page: 8314
  ident: CR63
  article-title: Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.20-22-08305.2000
– volume: 142
  start-page: 1
  year: 2006
  end-page: 20
  ident: CR34
  article-title: Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2006.06.027
– volume: 181
  start-page: 791
  year: 2008
  end-page: 801
  ident: CR2
  article-title: DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200711021
– volume: 19
  start-page: 849
  year: 2009
  end-page: 860
  ident: CR50
  article-title: Quantitative analysis of the expression of dopamine D1 and D2 receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex
  publication-title: Cereb Cortex
  doi: 10.1093/cercor/bhn134
– volume: 109
  start-page: 99
  year: 2000
  end-page: 111
  ident: CR48
  article-title: The effects of local application of D2 selective dopaminergic drugs into the medial prefrontal cortex of rats in a delayed spatial choice task
  publication-title: Behav Brain Res
  doi: 10.1016/S0166-4328(99)00166-7
– volume: 52
  start-page: 179
  year: 2006
  end-page: 196
  ident: CR41
  article-title: Modeling madness in mice: one piece at a time
  publication-title: Neuron
  doi: 10.1016/j.neuron.2006.09.023
– start-page: 107
  year: 2009
  end-page: 241
  ident: CR1
  article-title: Dysbindin-1 and its protein family
  publication-title: Handbook of Neurochemistry and Molecular Neurobiology
  doi: 10.1007/978-0-387-30410-6_5
– volume: 58
  start-page: 231
  year: 1998
  end-page: 236
  ident: CR54
  article-title: Subpopulations of cortical GABAergic interneurons differ by their expression of D1 and D2 dopamine receptor subtypes
  publication-title: Brain Res Mol Brain Res
  doi: 10.1016/S0169-328X(98)00118-1
– volume: 71
  start-page: 337
  year: 2002
  end-page: 348
  ident: CR7
  article-title: Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia
  publication-title: Am J Hum Genet
  doi: 10.1086/341750
– volume: 72
  start-page: 185
  year: 2003
  end-page: 190
  ident: CR6
  article-title: Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families
  publication-title: Am J Hum Genet
  doi: 10.1086/345463
– volume: 61
  start-page: 544
  year: 2004
  end-page: 555
  ident: CR10
  article-title: Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.61.6.544
– volume: 51
  start-page: 485
  year: 2002
  end-page: 492
  ident: CR57
  article-title: Reduced communication between frontal and temporal lobes during talking in schizophrenia
  publication-title: Biol Psychiatry
  doi: 10.1016/S0006-3223(01)01335-X
– volume: 113
  start-page: 1353
  year: 2004
  end-page: 1363
  ident: CR8
  article-title: Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia
  publication-title: J Clin Invest
  doi: 10.1172/JCI200420425
– volume: 61
  start-page: 336
  year: 2004
  end-page: 344
  ident: CR12
  article-title: Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1)
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.61.4.336
– volume: 1
  start-page: 11
  year: 2008
  ident: CR30
  article-title: Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia
  publication-title: Mol Brain
  doi: 10.1186/1756-6606-1-11
– volume: 152
  start-page: 403
  year: 2004
  end-page: 412
  ident: CR61
  article-title: Factors governing prepulse inhibition and prepulse facilitation of the acoustic startle response in mice
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2003.10.025
– volume: 156
  start-page: 234
  year: 2001
  end-page: 258
  ident: CR40
  article-title: Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies
  publication-title: Psychopharmacology
  doi: 10.1007/s002130100810
– volume: 1003
  start-page: 138
  year: 2003
  end-page: 158
  ident: CR15
  article-title: Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment
  publication-title: Ann NY Acad Sci
  doi: 10.1196/annals.1300.063
– volume: 8
  start-page: 390
  year: 2009
  end-page: 397
  ident: CR31
  article-title: Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background
  publication-title: Genes Brain Behav
  doi: 10.1111/j.1601-183X.2009.00477.x
– volume: 12
  start-page: 103
  year: 2005
  end-page: 110
  ident: CR24
  article-title: A role for prefrontal calcium-sensitive protein phosphatase and kinase activities in working memory
  publication-title: Learn Mem (Cold Spring Harbor, NY)
  doi: 10.1101/lm.89405
– volume: 59
  start-page: 107
  year: 1999
  end-page: 128
  ident: CR39
  article-title: The neurobiology of startle
  publication-title: Prog Neurobiol
  doi: 10.1016/S0301-0082(98)00098-7
– volume: 62
  start-page: 379
  year: 2005
  end-page: 386
  ident: CR55
  article-title: Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.62.4.379
– volume: 155
  start-page: 69
  year: 2001
  end-page: 77
  ident: CR62
  article-title: The role of D2-like dopamine receptors in the locomotor stimulant effects of cocaine in mice
  publication-title: Psychopharmacology
  doi: 10.1007/s002130000668
– volume: 42
  start-page: 707
  year: 1998
  end-page: 711
  ident: CR16
  article-title: The cortical dopamine system: role in memory and cognition
  publication-title: Adv Pharmacol (San Diego, Calif)
  doi: 10.1016/S1054-3589(08)60846-7
– volume: 742
  start-page: 17
  year: 1996
  end-page: 24
  ident: CR38
  article-title: Rapid sampling of extracellular dopamine in the rat prefrontal cortex during food consumption, handling and exposure to novelty
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(96)00945-6
– volume: 7
  start-page: 170
  year: 2000
  end-page: 179
  ident: CR32
  article-title: Strain-dependent differences in LTP and hippocampus-dependent memory in inbred mice
  publication-title: Learn Mem
  doi: 10.1101/lm.7.3.170
– volume: 21
  start-page: 3628
  year: 2001
  end-page: 3638
  ident: CR52
  article-title: Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.21-10-03628.2001
– volume: 58
  start-page: 231
  year: 1998
  ident: BFmp2010106_CR54
  publication-title: Brain Res Mol Brain Res
  doi: 10.1016/S0169-328X(98)00118-1
– volume: 7
  start-page: 1039
  year: 2002
  ident: BFmp2010106_CR58
  publication-title: Mol Psychiatry
  doi: 10.1038/sj.mp.4001159
– volume: 92
  start-page: 243
  year: 2009
  ident: BFmp2010106_CR60
  publication-title: Neurobiol Learn Mem
  doi: 10.1016/j.nlm.2008.05.015
– volume: 61
  start-page: 425
  year: 2009
  ident: BFmp2010106_CR26
  publication-title: Neuron
  doi: 10.1016/j.neuron.2008.12.015
– volume: 52
  start-page: 179
  year: 2006
  ident: BFmp2010106_CR41
  publication-title: Neuron
  doi: 10.1016/j.neuron.2006.09.023
– volume: 35
  start-page: 84
  year: 2003
  ident: BFmp2010106_CR18
  publication-title: Nat Genet
  doi: 10.1038/ng1229
– volume: 23
  start-page: 9752
  year: 2003
  ident: BFmp2010106_CR65
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.23-30-09752.2003
– volume: 72
  start-page: 185
  year: 2003
  ident: BFmp2010106_CR6
  publication-title: Am J Hum Genet
  doi: 10.1086/345463
– volume: 59
  start-page: 107
  year: 1999
  ident: BFmp2010106_CR39
  publication-title: Prog Neurobiol
  doi: 10.1016/S0301-0082(98)00098-7
– volume: 7
  start-page: 170
  year: 2000
  ident: BFmp2010106_CR32
  publication-title: Learn Mem
  doi: 10.1101/lm.7.3.170
– volume: 62
  start-page: 379
  year: 2005
  ident: BFmp2010106_CR55
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.62.4.379
– volume: 179
  start-page: 87
  year: 2009
  ident: BFmp2010106_CR23
  publication-title: Prog Brain Res
  doi: 10.1016/S0079-6123(09)17910-4
– volume: 27
  start-page: 12390
  year: 2007
  ident: BFmp2010106_CR13
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1689-07.2007
– volume: 326
  start-page: 1127
  year: 2009
  ident: BFmp2010106_CR21
  publication-title: Science
  doi: 10.1126/science.1179685
– volume: 23
  start-page: 867
  year: 2003
  ident: BFmp2010106_CR25
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.23-03-00867.2003
– volume: 106
  start-page: 21395
  year: 2009
  ident: BFmp2010106_CR22
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0910499106
– volume: 61
  start-page: 336
  year: 2004
  ident: BFmp2010106_CR12
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.61.4.336
– volume: 19
  start-page: 786
  year: 2008
  ident: BFmp2010106_CR59
  publication-title: Behav Pharmacol
  doi: 10.1097/FBP.0b013e32831c3b2b
– volume: 106
  start-page: 19593
  year: 2009
  ident: BFmp2010106_CR14
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0904289106
– volume: 1
  start-page: 11
  year: 2008
  ident: BFmp2010106_CR30
  publication-title: Mol Brain
  doi: 10.1186/1756-6606-1-11
– volume: 61
  start-page: 225
  year: 1994
  ident: BFmp2010106_CR42
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(94)90226-7
– volume: 109
  start-page: 99
  year: 2000
  ident: BFmp2010106_CR48
  publication-title: Behav Brain Res
  doi: 10.1016/S0166-4328(99)00166-7
– volume: 21
  start-page: 3628
  year: 2001
  ident: BFmp2010106_CR52
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.21-10-03628.2001
– volume: 104
  start-page: 20552
  year: 2007
  ident: BFmp2010106_CR47
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0707106104
– volume: 142
  start-page: 1
  year: 2006
  ident: BFmp2010106_CR34
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2006.06.027
– volume: 24
  start-page: 5131
  year: 2004
  ident: BFmp2010106_CR45
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1021-04.2004
– volume: 15
  start-page: 1563
  year: 2006
  ident: BFmp2010106_CR3
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddi481
– volume: 33
  start-page: 67
  year: 2007
  ident: BFmp2010106_CR29
  publication-title: J Chem Neuroanat
  doi: 10.1016/j.jchemneu.2006.12.005
– volume: 18
  start-page: 3851
  year: 2009
  ident: BFmp2010106_CR11
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddp329
– volume: 742
  start-page: 17
  year: 1996
  ident: BFmp2010106_CR38
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(96)00945-6
– volume: 71
  start-page: 337
  year: 2002
  ident: BFmp2010106_CR7
  publication-title: Am J Hum Genet
  doi: 10.1086/341750
– volume: 12
  start-page: 103
  year: 2005
  ident: BFmp2010106_CR24
  publication-title: Learn Mem (Cold Spring Harbor, NY)
  doi: 10.1101/lm.89405
– volume: 470
  start-page: 134
  year: 2010
  ident: BFmp2010106_CR49
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2009.12.071
– volume: 52
  start-page: 309
  year: 2000
  ident: BFmp2010106_CR44
  publication-title: Brain Res Bull
  doi: 10.1016/S0361-9230(99)00243-9
– volume: 61
  start-page: 544
  year: 2004
  ident: BFmp2010106_CR10
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.61.6.544
– volume: 156
  start-page: 234
  year: 2001
  ident: BFmp2010106_CR40
  publication-title: Psychopharmacology
  doi: 10.1007/s002130100810
– volume: 5
  start-page: 97
  year: 2004
  ident: BFmp2010106_CR51
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn1327
– start-page: 107
  volume-title: Handbook of Neurochemistry and Molecular Neurobiology
  year: 2009
  ident: BFmp2010106_CR1
  doi: 10.1007/978-0-387-30410-6_5
– volume: 181
  start-page: 791
  year: 2008
  ident: BFmp2010106_CR2
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200711021
– volume: 1003
  start-page: 138
  year: 2003
  ident: BFmp2010106_CR15
  publication-title: Ann NY Acad Sci
  doi: 10.1196/annals.1300.063
– volume: 42
  start-page: 707
  year: 1998
  ident: BFmp2010106_CR16
  publication-title: Adv Pharmacol (San Diego, Calif)
  doi: 10.1016/S1054-3589(08)60846-7
– volume: 303
  start-page: 853
  year: 2004
  ident: BFmp2010106_CR46
  publication-title: Science
  doi: 10.1126/science.1091162
– volume: 126
  start-page: 183
  year: 2000
  ident: BFmp2010106_CR37
  publication-title: Prog Brain Res
  doi: 10.1016/S0079-6123(00)26014-7
– volume: 152
  start-page: 403
  year: 2004
  ident: BFmp2010106_CR61
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2003.10.025
– volume: 155
  start-page: 69
  year: 2001
  ident: BFmp2010106_CR62
  publication-title: Psychopharmacology
  doi: 10.1007/s002130000668
– volume: 34
  start-page: 2601
  year: 2009
  ident: BFmp2010106_CR20
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2009.90
– volume: 51
  start-page: 1008
  year: 2002
  ident: BFmp2010106_CR56
  publication-title: Biol Psychiatry
  doi: 10.1016/S0006-3223(02)01316-1
– volume: 28
  start-page: 8709
  year: 2008
  ident: BFmp2010106_CR27
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2077-08.2008
– volume: 49
  start-page: 603
  year: 2006
  ident: BFmp2010106_CR33
  publication-title: Neuron
  doi: 10.1016/j.neuron.2006.01.023
– volume: 51
  start-page: 485
  year: 2002
  ident: BFmp2010106_CR57
  publication-title: Biol Psychiatry
  doi: 10.1016/S0006-3223(01)01335-X
– volume: 45
  start-page: 454
  year: 2007
  ident: BFmp2010106_CR36
  publication-title: Neuropsychologia
  doi: 10.1016/j.neuropsychologia.2006.06.016
– volume: 98
  start-page: 105
  year: 2008
  ident: BFmp2010106_CR9
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2007.05.041
– volume: 19
  start-page: 849
  year: 2009
  ident: BFmp2010106_CR50
  publication-title: Cereb Cortex
  doi: 10.1093/cercor/bhn134
– volume: 421
  start-page: 47
  year: 2007
  ident: BFmp2010106_CR19
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2007.05.019
– volume: 345
  start-page: 904
  year: 2006
  ident: BFmp2010106_CR17
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2006.04.163
– volume: 10
  start-page: 376
  year: 2007
  ident: BFmp2010106_CR35
  publication-title: Nat Neurosci
  doi: 10.1038/nn1846
– volume: 8
  start-page: 390
  year: 2009
  ident: BFmp2010106_CR31
  publication-title: Genes Brain Behav
  doi: 10.1111/j.1601-183X.2009.00477.x
– volume: 82
  start-page: 316
  year: 2002
  ident: BFmp2010106_CR28
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.2002.00967.x
– volume: 75
  start-page: 253
  year: 1996
  ident: BFmp2010106_CR43
  publication-title: Biol Cybern
  doi: 10.1007/s004220050292
– volume: 74
  start-page: 1
  year: 2004
  ident: BFmp2010106_CR53
  publication-title: Prog Neurobiol
  doi: 10.1016/j.pneurobio.2004.05.006
– volume: 31
  start-page: 2002
  year: 2006
  ident: BFmp2010106_CR4
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1301003
– volume: 63
  start-page: 24
  year: 2008
  ident: BFmp2010106_CR5
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2006.12.025
– volume: 20
  start-page: 8305
  year: 2000
  ident: BFmp2010106_CR63
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.20-22-08305.2000
– volume: 113
  start-page: 1353
  year: 2004
  ident: BFmp2010106_CR8
  publication-title: J Clin Invest
  doi: 10.1172/JCI200420425
– volume: 98
  start-page: 1964
  year: 2001
  ident: BFmp2010106_CR64
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.98.4.1964
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Snippet Dysbindin-1 regulates D2-receptor trafficking and is implicated in schizophrenia and related cognitive abnormalities, but whether this molecular effect...
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SubjectTerms 631/378/1457/1945
631/378/1689/1761
631/92/436/2388
Action Potentials - drug effects
Action Potentials - genetics
Adult and adolescent clinical studies
Amphetamine - adverse effects
Animals
Behavior
Behavioral Sciences
Binding proteins
Biological and medical sciences
Biological Psychology
Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism
Carrier Proteins - genetics
Cognition & reasoning
Cognitive ability
Disease Models, Animal
Dopamine
Dopamine - metabolism
Dopamine Agents - pharmacology
Dopaminergic mechanisms
Dysbindin
Dystrophin-Associated Proteins
Gene Expression Regulation, Enzymologic - drug effects
Gene Expression Regulation, Enzymologic - genetics
Genes
Genetic aspects
Genetic engineering
Genetic regulation
Hyperkinesis - drug therapy
Hyperkinesis - etiology
Hyperkinesis - genetics
Kinases
Maze Learning - drug effects
Medical sciences
Medicine
Medicine & Public Health
Memory
Memory Disorders - drug therapy
Memory Disorders - etiology
Memory, Short-Term - drug effects
Memory, Short-Term - physiology
Mental health
Mice
Mice, Inbred DBA
Mice, Knockout
Motor Activity - drug effects
Motor Activity - genetics
Mutation
Neurosciences
original-article
Pharmacotherapy
Prefrontal cortex
Prefrontal Cortex - drug effects
Prefrontal Cortex - pathology
Prefrontal Cortex - physiopathology
Properties
Protein expression
Proteins
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Psychosis
Pyramidal Cells - drug effects
Reaction Time - drug effects
Reaction Time - genetics
Receptors, Dopamine D2 - metabolism
Schizophrenia
Schizophrenia - complications
Schizophrenia - pathology
Sensory Gating - drug effects
Sensory Gating - genetics
Stress, Psychological - physiopathology
Title Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways
URI https://link.springer.com/article/10.1038/mp.2010.106
https://www.ncbi.nlm.nih.gov/pubmed/20956979
https://www.proquest.com/docview/916339599
https://www.proquest.com/docview/914299889
https://www.proquest.com/docview/968171662
https://pubmed.ncbi.nlm.nih.gov/PMC3388848
Volume 17
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