Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids

• Published in: Cell research Vol. 29; no. 4; pp. 265 - 273
• Main Authors: Xu, Yan-Peng, Qiu, Yang, Zhang, Boya, Chen, Guilai, Chen, Qi, Wang, Miao, Mo, Fan, Xu, Jiuyue, Wu, Jin, Zhang, Rong-Rong, Cheng, Meng-Li, Zhang, Na-Na, Lyu, Bao, Zhu, Wen-Liang, Wu, Meng-Hua, Ye, Qing, Zhang, Da, Man, Jiang-Hong, Li, Xiao-Feng, Cui, Jie, Xu, Zhiheng, Hu, Baoyang, Zhou, Xi, Qin, Cheng-Feng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2019; Nature Publishing Group
• Subjects: 45/100; 45/91; 631/1647; 631/250/262; 631/532/2182; 82/51; Ablation; Animals; Antibiotics; Antiviral drugs; Biomedical and Life Sciences; Brain; Brain - immunology; Brain - pathology; Cell Biology; Cell Line; Cells (biology); Enoxacin; Enoxacin - pharmacology; Fetuses; Humans; Immunity; Immunity, Innate; Infections; Life Sciences; Microcephaly; Neural stem cells; Neural Stem Cells - immunology; Neural Stem Cells - pathology; Organoids; Organoids - immunology; Organoids - pathology; Phenotypes; Progenitor cells; Public health; RNA Interference; RNA, Viral - immunology; RNA-mediated interference; Somatic cells; Vector-borne diseases; Viral infections; Virus Replication; Viruses; Western Hemisphere; Zika virus; Zika Virus - genetics; Zika Virus - immunology; Zika Virus - physiology; Zika Virus Infection - immunology

The re-emergence of Zika virus (ZIKV) in the Western Hemisphere has resulted in global public health crisis since 2015. ZIKV preferentially infects and targets human neural progenitor cells (hNPCs) and causes fetal microcephaly upon maternal infection. hNPCs not only play critical roles during fetal...