Dietary supplementation with purified citrus limonin glucoside does not alter ex vivo functions of circulating T lymphocytes or monocytes in overweight/obese human adults - Zunino, Susan J.; Storms, David H.; Freytag, Tammy L.; Adkins, Yuriko C.; Bonnel, Ellen L.; Woodhouse, Leslie R.; Breksa, Andrew P.; Manners, Gary D.; Mackey, Bruce E.; Kelley, Darshan S. (Nutrition research (New York, N.Y.), 2016)
Keywords: adaptive immunity; Adult; adults; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Anti-Inflammatory Agents, Non-Steroidal - metabolism; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; antibodies; beverages; Beverages - adverse effects; Biomarkers - blood; Biomarkers - metabolism; Body Mass Index; Cell Proliferation; Cells, Cultured; Citrus; Citrus - chemistry; citrus fruits; Citrus limonin glucoside; Cross-Over Studies; Cytokines; dietary supplements; Dietary Supplements - adverse effects; Double-Blind Method; Female; flow cytometry; Fruit - chemistry; Gastroenterology and Hepatology; glucosides; Glucosides - adverse effects; Glucosides - metabolism; Glucosides - therapeutic use; Hepatitis - etiology; Hepatitis - prevention & control; Humans; inflammation; interferon-gamma; interleukin-10; interleukin-1beta; interleukin-4; interleukin-6; limonin; Limonins - adverse effects; Limonins - metabolism; Limonins - therapeutic use; limonoids; lipopolysaccharides; Male; Metabolic Syndrome - etiology; Metabolic Syndrome - prevention & control; Middle Aged; Monocytes; Monocytes - immunology; Monocytes - metabolism; Monocytes - pathology; obesity; Obesity - diet therapy; Obesity - immunology; Obesity - metabolism; Obesity - pathology; Overweight - diet therapy; Overweight - immunology; Overweight - metabolism; Overweight - pathology; Overweight/obese humans; placebos; T lymphocytes; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; T-Lymphocytes - pathology; tumor necrosis factor-alpha; T lymphocytes; CRP; PBS; IL; Cytokines; Overweight/obese humans; PBMC; LPS; Citrus limonin glucoside; IFN; Monocytes; APC; TNF-α; LDL; PE; LG; MMP-9; BMI; C-reactive protein; tumor necrosis factor α; phosphate-buffered saline; limonin glucoside; interleukin; matrix metallopeptidase 9; body mass index; allophycocyanin; interferon; low-density lipoprotein; phycoerythrin; TNF- α