New aspects of amino acid metabolism in cancer

• Published in: British journal of cancer Vol. 122; no. 2; pp. 150 - 156
• Main Authors: Vettore, Lisa, Westbrook, Rebecca L., Tennant, Daniel A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2020; Nature Publishing Group
• Subjects: 631/67/2327; 631/67/327; Amino acids; Amino Acids - genetics; Amino Acids - metabolism; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Cell Proliferation - genetics; Drug Resistance; Energy Metabolism - genetics; Epidemiology; Humans; Metabolism; Molecular Medicine; Neoplasms - genetics; Neoplasms - metabolism; Oncology; Protein biosynthesis; Protein Biosynthesis - genetics; Review; Review Article; Tumor Microenvironment - genetics

An abundant supply of amino acids is important for cancers to sustain their proliferative drive. Alongside their direct role as substrates for protein synthesis, they can have roles in energy generation, driving the synthesis of nucleosides and maintenance of cellular redox homoeostasis. As cancer c...