Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2

• Published in: NPJ precision oncology Vol. 2; no. 1; p. 1
• Main Authors: Lv, Hongwei, Wang, Changzheng, Fang, Tian, Li, Ting, Lv, Guishuai, Han, Qin, Yang, Wen, Wang, Hongyang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.01.2018; Nature Publishing Group
• Subjects: 631/67/1059; 631/67/71; Apoptosis; Cancer Research; Cell cycle; DNA damage; Gene Therapy; Human Genetics; Internal Medicine; Liver cancer; Medicine; Medicine & Public Health; Oncology; Patients; Precision medicine; Stem cells; Targeted cancer therapy; Vitamin C

Vitamin C (L-ascorbic acid, ascorbate, VC) is a potential chemotherapeutic agent for cancer patients. However, the anti-tumor effects of pharmacologic VC on hepatocellular carcinoma (HCC) and liver cancer stem cells (CSCs) remain to be fully elucidated. Panels of human HCC cell lines as well as HCC...