Heterologous Prime/Boost Immunization of Rhesus Monkeys by Using Diverse Poxvirus Vectors

Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from...

Full description

Saved in:
Bibliographic Details
Published inJournal of Virology Vol. 81; no. 16; pp. 8563 - 8570
Main Authors SANTRA, Sampa, YUE SUN, MONTEFIORI, David C, LETVIN, Norman L, PARVANI, Jenny G, PHILIPPON, Valerie, WYAND, Michael S, MANSON, Kelledy, GOMEZ-YAFAL, Alicia, MAZZARA, Gail, PANICALI, Dennis, MARKHAM, Phillip D
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.08.2007
Subjects
Animals
Antibodies, Viral - blood
Biological and medical sciences
CD4 Lymphocyte Count
Fowlpox virus
Fundamental and applied biological sciences. Psychology
Genetic Vectors - genetics
Genetic Vectors - immunology
Human immunodeficiency virus 1
Immunity, Cellular
Immunization, Secondary - methods
Macaca mulatta
Microbiology
Miscellaneous
Poxviridae - genetics
Poxviridae - immunology
Poxvirus
RNA, Viral - blood
Simian immunodeficiency virus
Vaccination - methods
Vaccines and Antiviral Agents
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccinia virus
Vaccinia virus - genetics
Vaccinia virus - immunology
Virology
Virus Replication
Virus
Vertebrata
Immunization
Mammalia
Poxviridae
Primates
Simioidea
Macaca mulatta
Vaccine
Vector
Virology
Online AccessGet full text

Cover

Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList ABSTRACT As the diversity of potential immunogens increases within certain classes of vectors, the possibility has arisen of employing heterologous prime/boost immunizations using diverse members of the same family of vectors. The present study was initiated to explore the use of divergent pox vectors in a prime/boost regimen to elicit high-frequency cellular immune responses to human immunodeficiency virus type 1 envelope and simian immunodeficiency virus gag in rhesus monkeys. We demonstrated that monkeys vaccinated with a recombinant modified vaccinia virus Ankara (rMVA) prime/recombinant fowlpox virus (rFPV) boost regimen and monkeys vaccinated with a recombinant vaccinia virus prime/rFPV boost regimen developed comparable cellular immune responses that were greater in magnitude than those elicited by a homologous prime/boost with rMVA. Nevertheless, comparable magnitude recall cellular immune responses were observed in monkeys vaccinated with heterologous and homologous recombinant poxvirus following challenge with the CXCR4-tropic SHIV-89.6P. Consistent with this finding, comparable levels of containment of viral replication and CD4 + T-lymphocyte preservation were seen in these groups of recombinant poxvirus-vaccinated monkeys. This study supports further exploration of combining recombinant vectors of the same family in prime/boost immunization strategies to optimize vaccine-elicited cellular immune responses.
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
As the diversity of potential immunogens increases within certain classes of vectors, the possibility has arisen of employing heterologous prime/boost immunizations using diverse members of the same family of vectors. The present study was initiated to explore the use of divergent pox vectors in a prime/boost regimen to elicit high-frequency cellular immune responses to human immunodeficiency virus type 1 envelope and simian immunodeficiency virus gag in rhesus monkeys. We demonstrated that monkeys vaccinated with a recombinant modified vaccinia virus Ankara (rMVA) prime/recombinant fowlpox virus (rFPV) boost regimen and monkeys vaccinated with a recombinant vaccinia virus prime/rFPV boost regimen developed comparable cellular immune responses that were greater in magnitude than those elicited by a homologous prime/boost with rMVA. Nevertheless, comparable magnitude recall cellular immune responses were observed in monkeys vaccinated with heterologous and homologous recombinant poxvirus following challenge with the CXCR4-tropic SHIV-89.6P. Consistent with this finding, comparable levels of containment of viral replication and CD4 super(+) T-lymphocyte preservation were seen in these groups of recombinant poxvirus-vaccinated monkeys. This study supports further exploration of combining recombinant vectors of the same family in prime/boost immunization strategies to optimize vaccine-elicited cellular immune responses.
As the diversity of potential immunogens increases within certain classes of vectors, the possibility has arisen of employing heterologous prime/boost immunizations using diverse members of the same family of vectors. The present study was initiated to explore the use of divergent pox vectors in a prime/boost regimen to elicit high-frequency cellular immune responses to human immunodeficiency virus type 1 envelope and simian immunodeficiency virus gag in rhesus monkeys. We demonstrated that monkeys vaccinated with a recombinant modified vaccinia virus Ankara (rMVA) prime/recombinant fowlpox virus (rFPV) boost regimen and monkeys vaccinated with a recombinant vaccinia virus prime/rFPV boost regimen developed comparable cellular immune responses that were greater in magnitude than those elicited by a homologous prime/boost with rMVA. Nevertheless, comparable magnitude recall cellular immune responses were observed in monkeys vaccinated with heterologous and homologous recombinant poxvirus following challenge with the CXCR4-tropic SHIV-89.6P. Consistent with this finding, comparable levels of containment of viral replication and CD4 + T-lymphocyte preservation were seen in these groups of recombinant poxvirus-vaccinated monkeys. This study supports further exploration of combining recombinant vectors of the same family in prime/boost immunization strategies to optimize vaccine-elicited cellular immune responses.
As the diversity of potential immunogens increases within certain classes of vectors, the possibility has arisen of employing heterologous prime/boost immunizations using diverse members of the same family of vectors. The present study was initiated to explore the use of divergent pox vectors in a prime/boost regimen to elicit high-frequency cellular immune responses to human immunodeficiency virus type 1 envelope and simian immunodeficiency virus gag in rhesus monkeys. We demonstrated that monkeys vaccinated with a recombinant modified vaccinia virus Ankara (rMVA) prime/recombinant fowlpox virus (rFPV) boost regimen and monkeys vaccinated with a recombinant vaccinia virus prime/rFPV boost regimen developed comparable cellular immune responses that were greater in magnitude than those elicited by a homologous prime/boost with rMVA. Nevertheless, comparable magnitude recall cellular immune responses were observed in monkeys vaccinated with heterologous and homologous recombinant poxvirus following challenge with the CXCR4-tropic SHIV-89.6P. Consistent with this finding, comparable levels of containment of viral replication and CD4(+) T-lymphocyte preservation were seen in these groups of recombinant poxvirus-vaccinated monkeys. This study supports further exploration of combining recombinant vectors of the same family in prime/boost immunization strategies to optimize vaccine-elicited cellular immune responses.
Author Phillip D. Markham
Yue Sun
Dennis Panicali
Michael S. Wyand
Jenny G. Parvani
Alicia Gomez-Yafal
Kelledy Manson
David C. Montefiori
Norman L. Letvin
Valerie Philippon
Sampa Santra
Gail Mazzara
AuthorAffiliation Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, 1 Therion Biologics, 76 Rogers Street, Cambridge, Massachusetts 02142, 2 Advanced Bioscience Laboratories, Inc., 5510 Nicholson Lane, Kensington, Maryland 20895, 3 Department of Surgery, Laboratory for AIDS Vaccine Research and Development, Duke University Medical Center, Durham, North Carolina 27710 4
AuthorAffiliation_xml – name: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, 1 Therion Biologics, 76 Rogers Street, Cambridge, Massachusetts 02142, 2 Advanced Bioscience Laboratories, Inc., 5510 Nicholson Lane, Kensington, Maryland 20895, 3 Department of Surgery, Laboratory for AIDS Vaccine Research and Development, Duke University Medical Center, Durham, North Carolina 27710 4
Author_xml – sequence: 1
  givenname: Sampa
  surname: SANTRA
  fullname: SANTRA, Sampa
  organization: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, United States
– sequence: 2
  surname: YUE SUN
  fullname: YUE SUN
  organization: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, United States
– sequence: 3
  givenname: David C
  surname: MONTEFIORI
  fullname: MONTEFIORI, David C
  organization: Department of Surgery, Laboratory for AIDS Vaccine Research and Development, Duke University Medical Center, Durham, North Carolina 27770, United States
– sequence: 4
  givenname: Norman L
  surname: LETVIN
  fullname: LETVIN, Norman L
  organization: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, United States
– sequence: 5
  givenname: Jenny G
  surname: PARVANI
  fullname: PARVANI, Jenny G
  organization: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, United States
– sequence: 6
  givenname: Valerie
  surname: PHILIPPON
  fullname: PHILIPPON, Valerie
  organization: Therion Biologics, 76 Rogers Street, Cambridge, Massachusetts 02142, United States
– sequence: 7
  givenname: Michael S
  surname: WYAND
  fullname: WYAND, Michael S
  organization: Therion Biologics, 76 Rogers Street, Cambridge, Massachusetts 02142, United States
– sequence: 8
  givenname: Kelledy
  surname: MANSON
  fullname: MANSON, Kelledy
  organization: Therion Biologics, 76 Rogers Street, Cambridge, Massachusetts 02142, United States
– sequence: 9
  givenname: Alicia
  surname: GOMEZ-YAFAL
  fullname: GOMEZ-YAFAL, Alicia
  organization: Therion Biologics, 76 Rogers Street, Cambridge, Massachusetts 02142, United States
– sequence: 10
  givenname: Gail
  surname: MAZZARA
  fullname: MAZZARA, Gail
  organization: Therion Biologics, 76 Rogers Street, Cambridge, Massachusetts 02142, United States
– sequence: 11
  givenname: Dennis
  surname: PANICALI
  fullname: PANICALI, Dennis
  organization: Therion Biologics, 76 Rogers Street, Cambridge, Massachusetts 02142, United States
– sequence: 12
  givenname: Phillip D
  surname: MARKHAM
  fullname: MARKHAM, Phillip D
  organization: Advanced Bioscience Laboratories, Inc., 5510 Nicholson Lane, Kensington, Maryland 20895, United States
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18962904$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/17553898$$D View this record in MEDLINE/PubMed
BookMark eNqN0c1vFCEYBnBi2tht9ebZTEzsyWlhgAEuJlo_uk2NjbGNngjLvuzSzkALs6vrX1_a3bR680QCvzzw8uyirRADIPSC4ANCGnl4cjE-wFgwVmPxBI0IVrLmnLAtNMK4aWpO5Y8dtJvzJcaEsZY9RTtE8LKt5Aj9PIYBUuziLC5ydZZ8D4fvY8xDNe77RfB_zOBjqKKrvs0hF_IlhitY5Wqyqs6zD7Pqg19CylCdxd9Ln4q4ADvElJ-hbWe6DM836x46__Tx-9Fxffr18_jo3WltOW2HmlmrhIWpaBUDwagQ1jqmJpwoRaiiVknKbeukIwRPQWGHQUkjmOCOSgd0D71d514vJj1MLYQhmU5fl1FMWulovP73JPi5nsWlJooTSkUJ2N8EpHizgDzo3mcLXWcClE_RAgsq8H_ABlNKWswKfLOGNsWcE7iH1xCs70rTpTR9X5rGd7kv_57gEW9aKuD1BphsTeeSCdbnRydV26j7e1-t3dzP5r98Am1yry-XXkuiSaslbym9BQm8rfg
CitedBy_id crossref_primary_10_1016_j_vaccine_2012_10_093
crossref_primary_10_1038_mtm_2016_7
crossref_primary_10_1016_j_vaccine_2009_01_010
crossref_primary_10_1038_s41541_020_00277_1
crossref_primary_10_1128_JVI_00204_08
crossref_primary_10_1016_j_imlet_2018_06_004
crossref_primary_10_1517_14712598_8_9_1347
crossref_primary_10_1016_j_virol_2010_07_004
crossref_primary_10_1128_JVI_00550_09
crossref_primary_10_1016_j_chom_2020_07_018
crossref_primary_10_1186_1743_422X_8_429
crossref_primary_10_1016_j_vaccine_2010_01_065
crossref_primary_10_3390_vaccines8030511
crossref_primary_10_1016_j_vaccine_2009_08_026
crossref_primary_10_1038_gt_2009_122
crossref_primary_10_3390_v2020435
crossref_primary_10_1080_14760584_2023_2193266
crossref_primary_10_1128_JVI_03276_13
crossref_primary_10_1016_j_vaccine_2008_03_090
crossref_primary_10_1556_AMicr_60_2013_4_6
crossref_primary_10_4161_hv_28974
crossref_primary_10_1038_icb_2010_99
crossref_primary_10_1128_JVI_02216_07
crossref_primary_10_1016_j_vaccine_2009_07_106
crossref_primary_10_3390_vaccines9101131
crossref_primary_10_4161_hv_20778
crossref_primary_10_1371_journal_ppat_1000153
crossref_primary_10_1128_JVI_01120_17
crossref_primary_10_1128_IAI_00487_08
crossref_primary_10_1586_14760584_2013_845531
crossref_primary_10_1016_j_copbio_2007_10_010
crossref_primary_10_1016_j_omto_2018_05_001
crossref_primary_10_1186_1479_5876_5_60
crossref_primary_10_1128_JVI_01193_10
crossref_primary_10_4049_jimmunol_0803746
Cites_doi 10.1073/pnas.0401954101
10.1097/01.qai.0000184857.39318.4f
10.1126/science.290.5491.486
10.1016/S0092-8674(01)00482-2
10.1089/aid.1991.7.991
10.1128/JVI.75.23.11603-11613.2001
10.4049/jimmunol.170.3.1416
10.1128/JVI.77.11.6305-6313.2003
10.1128/jvi.64.12.5948-5957.1990
10.1016/0076-6879(93)17089-N
10.1038/nature01470
10.1038/415331a
10.1126/science.1124226
10.1146/annurev.med.55.091902.104344
10.1126/science.1058915
10.1099/0022-1317-72-5-1031
10.4049/jimmunol.169.9.4778
10.1128/JVI.01458-06
10.1128/JVI.79.22.14161-14168.2005
10.1128/JVI.00558-06
10.1128/jvi.70.6.3741-3752.1996
10.1128/JVI.79.24.15547-15555.2005
10.1128/JVI.02392-06
10.1007/BF01641272
10.1073/pnas.0404620101
10.1073/pnas.93.21.11349
10.1007/978-1-4899-1382-1_2
10.4049/jimmunol.172.10.6290
ContentType Journal Article
Copyright 2007 INIST-CNRS
Copyright © 2007, American Society for Microbiology 2007
Copyright_xml – notice: 2007 INIST-CNRS
– notice: Copyright © 2007, American Society for Microbiology 2007
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QO
7T5
7U9
8FD
FR3
H94
P64
7X8
5PM
DOI 10.1128/JVI.00744-07
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Biotechnology Research Abstracts
Immunology Abstracts
Virology and AIDS Abstracts
Technology Research Database
Engineering Research Database
AIDS and Cancer Research Abstracts
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Virology and AIDS Abstracts
Biotechnology Research Abstracts
Technology Research Database
AIDS and Cancer Research Abstracts
Immunology Abstracts
Engineering Research Database
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitleList CrossRef

Virology and AIDS Abstracts

MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1098-5514
EndPage 8570
ExternalDocumentID 10_1128_JVI_00744_07
17553898
18962904
jvi_81_16_8563
Genre Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIAID NIH HHS
  grantid: N01 AI 30033
– fundername: NIAID NIH HHS
  grantid: N01AI60005
– fundername: NIAID NIH HHS
  grantid: P30 AI060354
– fundername: NIAID NIH HHS
  grantid: AI 060354
– fundername: NIAID NIH HHS
  grantid: N01AI30033
– fundername: NIAID NIH HHS
  grantid: N01 AI 60005
GroupedDBID ---
-~X
.55
.GJ
08R
0R~
18M
29L
2WC
39C
3O-
4.4
41~
53G
5GY
5RE
5VS
6TJ
85S
AAUGY
AAYJJ
ABPPZ
ABPTK
ACGFO
ACNCT
ADBBV
AENEX
AFDAS
AFFNX
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CS3
D0S
DIK
E3Z
EBS
EJD
F20
F5P
FRP
GX1
H13
HYE
HZ~
IH2
IQODW
KQ8
MVM
N9A
O9-
OHT
OK1
P2P
RHF
RHI
RNS
RPM
RSF
TR2
UCJ
UPT
VH1
W2D
W8F
WH7
WOQ
X7M
XFK
Y6R
YQT
ZA5
ZGI
ZXP
~02
~KM
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
AGVNZ
CITATION
7QO
7T5
7U9
8FD
FR3
H94
P64
7X8
5PM
ID FETCH-LOGICAL-c536t-4cc97ced7694e74377ccf49b51991393c9835c6f8f110de90f0e98a7475f38fe3
IEDL.DBID RPM
ISSN 0022-538X
IngestDate Tue Sep 17 21:21:08 EDT 2024
Sat Aug 17 02:13:11 EDT 2024
Wed Jul 24 14:41:25 EDT 2024
Thu Sep 12 17:35:48 EDT 2024
Thu May 23 23:11:17 EDT 2024
Sun Oct 22 16:07:18 EDT 2023
Wed May 18 15:33:05 EDT 2016
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 16
Keywords Virus
Vertebrata
Immunization
Mammalia
Poxviridae
Primates
Simioidea
Macaca mulatta
Vaccine
Vector
Virology
Language English
License CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c536t-4cc97ced7694e74377ccf49b51991393c9835c6f8f110de90f0e98a7475f38fe3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Corresponding author. Mailing address: Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RE113, P.O. Box 15732, Boston, MA 02215. Phone: (617) 667-2766. Fax: (617) 667-8210. E-mail: nletvin@bidmc.harvard.edu
OpenAccessLink https://europepmc.org/articles/pmc1951337?pdf=render
PMID 17553898
PQID 20331604
PQPubID 23462
PageCount 8
ParticipantIDs pascalfrancis_primary_18962904
pubmed_primary_17553898
proquest_miscellaneous_20331604
highwire_asm_jvi_81_16_8563
crossref_primary_10_1128_JVI_00744_07
proquest_miscellaneous_70737037
pubmedcentral_primary_oai_pubmedcentral_nih_gov_1951337
PublicationCentury 2000
PublicationDate 2007-08-01
PublicationDateYYYYMMDD 2007-08-01
PublicationDate_xml – month: 08
  year: 2007
  text: 2007-08-01
  day: 01
PublicationDecade 2000
PublicationPlace Washington, DC
PublicationPlace_xml – name: Washington, DC
– name: United States
PublicationTitle Journal of Virology
PublicationTitleAlternate J Virol
PublicationYear 2007
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References 8718576 - Adv Exp Med Biol. 1996;397:7-13
16763152 - Science. 2006 Jun 9;312(5779):1530-3
11797011 - Nature. 2002 Jan 17;415(6869):331-5
12743287 - J Virol. 2003 Jun;77(11):6305-13
1667477 - AIDS Res Hum Retroviruses. 1991 Dec;7(12):991-8
16306625 - J Virol. 2005 Dec;79(24):15547-55
12646921 - Nature. 2003 Mar 20;422(6929):307-12
15128818 - J Immunol. 2004 May 15;172(10):6290-7
11039923 - Science. 2000 Oct 20;290(5491):486-92
16254351 - J Virol. 2005 Nov;79(22):14161-8
16280691 - J Acquir Immune Defic Syndr. 2005 Dec 1;40(4):383-7
17251286 - J Virol. 2007 Apr;81(7):3465-76
15297611 - Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12324-9
11551502 - Cell. 2001 Sep 7;106(5):539-49
2243381 - J Virol. 1990 Dec;64(12):5948-57
8876138 - Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11349-53
2033387 - J Gen Virol. 1991 May;72 ( Pt 5):1031-8
16912320 - J Virol. 2006 Sep;80(17):8729-38
12391187 - J Immunol. 2002 Nov 1;169(9):4778-87
14746526 - Annu Rev Med. 2004;55:355-72
12538702 - J Immunol. 2003 Feb 1;170(3):1416-22
8474351 - Methods Enzymol. 1993;217:557-81
11393868 - Science. 2001 Apr 6;292(5514):69-74
8648709 - J Virol. 1996 Jun;70(6):3741-52
11689642 - J Virol. 2001 Dec;75(23):11603-13
15258286 - Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11088-93
16943292 - J Virol. 2006 Nov;80(22):10950-6
e_1_3_2_26_2
e_1_3_2_27_2
e_1_3_2_28_2
e_1_3_2_29_2
e_1_3_2_20_2
e_1_3_2_21_2
e_1_3_2_22_2
e_1_3_2_23_2
e_1_3_2_24_2
e_1_3_2_25_2
e_1_3_2_9_2
e_1_3_2_15_2
e_1_3_2_8_2
e_1_3_2_16_2
e_1_3_2_7_2
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_18_2
e_1_3_2_19_2
e_1_3_2_10_2
e_1_3_2_5_2
e_1_3_2_11_2
e_1_3_2_4_2
e_1_3_2_12_2
e_1_3_2_3_2
e_1_3_2_13_2
e_1_3_2_2_2
e_1_3_2_14_2
References_xml – ident: e_1_3_2_24_2
  doi: 10.1073/pnas.0401954101
– ident: e_1_3_2_13_2
  doi: 10.1097/01.qai.0000184857.39318.4f
– ident: e_1_3_2_3_2
  doi: 10.1126/science.290.5491.486
– ident: e_1_3_2_23_2
  doi: 10.1016/S0092-8674(01)00482-2
– ident: e_1_3_2_14_2
  doi: 10.1089/aid.1991.7.991
– ident: e_1_3_2_7_2
  doi: 10.1128/JVI.75.23.11603-11613.2001
– ident: e_1_3_2_8_2
  doi: 10.4049/jimmunol.170.3.1416
– ident: e_1_3_2_5_2
  doi: 10.1128/JVI.77.11.6305-6313.2003
– ident: e_1_3_2_10_2
  doi: 10.1128/jvi.64.12.5948-5957.1990
– ident: e_1_3_2_17_2
  doi: 10.1016/0076-6879(93)17089-N
– ident: e_1_3_2_29_2
  doi: 10.1038/nature01470
– ident: e_1_3_2_26_2
  doi: 10.1038/415331a
– ident: e_1_3_2_15_2
  doi: 10.1126/science.1124226
– ident: e_1_3_2_25_2
  doi: 10.1146/annurev.med.55.091902.104344
– ident: e_1_3_2_2_2
  doi: 10.1126/science.1058915
– ident: e_1_3_2_18_2
  doi: 10.1099/0022-1317-72-5-1031
– ident: e_1_3_2_11_2
  doi: 10.4049/jimmunol.169.9.4778
– ident: e_1_3_2_28_2
  doi: 10.1128/JVI.01458-06
– ident: e_1_3_2_20_2
  doi: 10.1128/JVI.79.22.14161-14168.2005
– ident: e_1_3_2_27_2
  doi: 10.1128/JVI.00558-06
– ident: e_1_3_2_12_2
  doi: 10.1128/jvi.70.6.3741-3752.1996
– ident: e_1_3_2_6_2
  doi: 10.1128/JVI.79.24.15547-15555.2005
– ident: e_1_3_2_9_2
  doi: 10.1128/JVI.02392-06
– ident: e_1_3_2_16_2
  doi: 10.1007/BF01641272
– ident: e_1_3_2_21_2
  doi: 10.1073/pnas.0404620101
– ident: e_1_3_2_22_2
  doi: 10.1073/pnas.93.21.11349
– ident: e_1_3_2_19_2
  doi: 10.1007/978-1-4899-1382-1_2
– ident: e_1_3_2_4_2
  doi: 10.4049/jimmunol.172.10.6290
SSID ssj0014464
Score 2.109766
Snippet Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
As the diversity of potential immunogens increases within certain classes of vectors, the possibility has arisen of employing heterologous prime/boost...
ABSTRACT As the diversity of potential immunogens increases within certain classes of vectors, the possibility has arisen of employing heterologous prime/boost...
SourceID pubmedcentral
proquest
crossref
pubmed
pascalfrancis
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 8563
SubjectTerms Animals
Antibodies, Viral - blood
Biological and medical sciences
CD4 Lymphocyte Count
Fowlpox virus
Fundamental and applied biological sciences. Psychology
Genetic Vectors - genetics
Genetic Vectors - immunology
Human immunodeficiency virus 1
Immunity, Cellular
Immunization, Secondary - methods
Macaca mulatta
Microbiology
Miscellaneous
Poxviridae - genetics
Poxviridae - immunology
Poxvirus
RNA, Viral - blood
Simian immunodeficiency virus
Vaccination - methods
Vaccines and Antiviral Agents
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccinia virus
Vaccinia virus - genetics
Vaccinia virus - immunology
Virology
Virus Replication
Title Heterologous Prime/Boost Immunization of Rhesus Monkeys by Using Diverse Poxvirus Vectors
URI http://jvi.asm.org/content/81/16/8563.abstract
https://www.ncbi.nlm.nih.gov/pubmed/17553898
https://search.proquest.com/docview/20331604
https://search.proquest.com/docview/70737037
https://pubmed.ncbi.nlm.nih.gov/PMC1951337
Volume 81
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYACamXqi19pLTgQ3sMefh9bGnRggRaVYC2JytxbLGomyCyRfDvGTtx6SLUQ49RJpblb8aeib-ZQegTaWoHp0CemrpsUsoalipZ5WlBhbNFY62sQ7XPEz45o0czNltDLObCBNK-qed77a_FXju_CNzKq4XJIk8smx7vF8p3JRHZOloXhMQQfbw6gPiGxhLhYM2zyHYvZXZ0fuhLZVOa5qH5nmAgoOTqkRTLBHuWZNXDQrmhw8VTLuhjJuVfR9PBC_R89Cnxl2HuL9GabV-hzaHL5N0W-jnxlBf_AFE-nvp6_tnXruuX-DAkhwyJmLhz-MeF7UEE7BxMu8f1HQ6MAvwtkDcsnna3N_NrkDgP__r71-js4Pvp_iQdOyqkhhG-TKkxShjbCK6oBd9BCGMcVTXzBCiiiFHgkBnupAOvoLEqd7kF6CDkYI5IZ8kbtNF2rX3nc72LUpTGEdJYyn2gW3DuYAMBvKmiVYI-x0XVV0PhDB0CjlJqwEEHHHQuErQdV1xX_UJf3sy1LHTBtWScJGhnBYSHoaTipcppgnYjKhoMw992VK2F5dRlTmBK_5IQsL3BhgdTeDug-DD6qBkJEiv4_hHwRblX34CuhuLco26-_-8vt9Gz4f-xJxl-QBvL69_2Izg-y3onKPo9GkcDGA
link.rule.ids 230,315,733,786,790,891,27957,27958,53827,53829
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKEYIL70IotDnAMZuHHT-OUKh2S1utULtaTlbi2OoCm1RNtqL8esZOTNkKIcEx8sRyPOPxTPz5G4Re46o0sAskkSqzKiJ5lUeCF0mUEmZ0WmnNS8f2eUzHp-Rgns83UO7vwjjQvioXo_rbclQvzhy28nypYo8Ti6dHe6mwVUlYfAvdhvWaMZ-kD4cHkOEQTxIO7XOPd894fDCbWLJsQqLEld9jOQgIvr4peaJgi5MsWpgq09e4-FMQehNL-dvmtP8Azfxn9ZiUr6NVV47UjxuMj__83Q_R_SFcDd_2zY_Qhq4fozt9AcurJ-jz2KJp7EOzasOpLRUQv2uatgsn7t5Jf8czbEz46Uy3IAIuBLxGG5ZXoQMrhO8dLkSH0-b75eICJGbuGKF9ik73P5zsjaOhWEOkcky7iCglmNIVo4JoCEsYU8oQUeYWW4UFVgJiPUUNNxBwVFokJtFgFZDN5AZzo_EW2qybWj-318jTjGXKYFxpQm0OnVJqwDeBKRFBigC98dqS5z0nh3S5TMYlKFg6BcuEBWjbq1IW7VJ-uVxInsqUSp5THKCdNe1ed8UFzURCArTr1S1hzdmDlKLWMJ0ySzAM6W8SDDwn-FIYwrPePK57H0wuQGzNcH4JWL7v9RYwB8f7Paj_xX-_uYvujk-ODuXh5PjjNrrX_6a2WMaXaLO7WOlXEF915Y5bTT8BfWolDQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagCMSF9yMU2hzgmM3Djh9HaFntFqhWiFYLFytxbHWBTVZNtqL8esZOTLsV4tBj5InleMbjmfjzNwi9xlVpYBdIIlVmVUTyKo8EL5IoJczotNKal47t85BOjsjBPJ9fKvXlQPuqXIzqn8tRvThx2MrVUsUeJxbPPu2lwlYlYfGqMvFNdAvWbCZ8oj4cIECWQzxROLTPPeY94_HB8dQSZhMSJa4EH8tBQPDNjcmTBVusZNHCdJm-zsW_AtGreMpLG9T4PvrmP63HpfwYrbtypH5fYX281rc_QPeGsDV824s8RDd0_Qjd7gtZnj9GXycWVWMfmnUbzmzJgPhd07RdOHX3T_q7nmFjws8nugURcCXgPdqwPA8daCHcd_gQHc6aX2eLU5A4dscJ7RN0NH7_ZW8SDUUbIpVj2kVEKcGUrhgVREN4wphShogytxgrLLASEPMpariBwKPSIjGJBuuArCY3mBuNn6Ktuqn1c3udPM1YpgzGlSbU5tIppQZ8FJgUEaQI0BuvMbnquTmky2kyLkHJ0ilZJixA216dsmiX8vvZQvJUplTynOIA7Wxo-KIrLmgmEhKgXa9yCWvPHqgUtYbplFmCYUj_k2DgQcGnwhCe9SZy0ftgdgFiG8bzV8Dyfm-2gEk4_u_BBF5c-81ddGe2P5Yfp4cfttHd_m-1hTS-RFvd6Vq_gjCrK3fcgvoDow0njQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Heterologous+prime%2Fboost+immunization+of+rhesus+monkeys+by+using+diverse+poxvirus+vectors&rft.jtitle=Journal+of+virology&rft.au=SANTRA%2C+Sampa&rft.au=YUE+SUN&rft.au=MONTEFIORI%2C+David+C&rft.au=LETVIN%2C+Norman+L&rft.date=2007-08-01&rft.pub=American+Society+for+Microbiology&rft.issn=0022-538X&rft.eissn=1098-5514&rft.volume=81&rft.issue=16&rft.spage=8563&rft.epage=8570&rft_id=info:doi/10.1128%2Fjvi.00744-07&rft.externalDBID=n%2Fa&rft.externalDocID=18962904
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-538X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-538X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-538X&client=summon