Regulation of Hypothalamo-Pituitary-Adrenocortical Responses to Stressors by the Nucleus of the Solitary Tract/Dorsal Vagal Complex

• Published in: Cellular and molecular neurobiology Vol. 38; no. 1; pp. 25 - 35
• Main Author: Herman, James P.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2018; Springer Nature B.V
• Subjects: Adrenal Cortex - drug effects; Adrenal Cortex - metabolism; Adrenal glands; Adrenocorticotropic hormone; Animals; Aortic Bodies - drug effects; Aortic Bodies - metabolism; Biomedical and Life Sciences; Biomedicine; Cell Biology; Corticosterone; Corticosterone - metabolism; Corticosterone - pharmacology; Corticotropin-releasing hormone; Glucagon; Glucagon-like peptide 1; Glucagon-Like Peptide 1 - metabolism; Glucagon-Like Peptide 1 - pharmacology; Glutamic Acid - metabolism; Glutamic Acid - pharmacology; Hindbrain; Humans; Hypothalamic-pituitary-adrenal axis; Hypothalamo-Hypophyseal System - drug effects; Hypothalamo-Hypophyseal System - physiology; Neurobiology; Neurosciences; Norepinephrine; Paraventricular nucleus; Pituitary; Pituitary-Adrenal System - drug effects; Pituitary-Adrenal System - physiology; Review Paper; Solitary Nucleus - drug effects; Solitary Nucleus - metabolism; Solitary tract nucleus; Stress, Psychological - metabolism; Stress, Psychological - psychology; Vagus nerve; Glucagon-like peptide-1; Norepinephrine; Paraventricular nucleus; Glucocorticoids; Corticotropin-releasing hormone; Prolactin-releasing peptide

Hindbrain neurons in the nucleus of the solitary tract (NTS) are critical for regulation of hypothalamo-pituitary-adrenocortical (HPA) responses to stress. It is well known that noradrenergic (as well as adrenergic) neurons in the NTS send direct projections to hypophysiotropic corticotropin-releasi...