Ubiquitination of Rheb governs growth factor-induced mTORC1 activation
Mechanistic target of rapamycin mTOR complex 1 (mTORC1) plays a key role in the integration of various environmental signals to regulate cell growth and metabolism. mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase. However, the regulatory mechan...
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Published in | Cell research Vol. 29; no. 2; pp. 136 - 150 |
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Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.02.2019
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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