Association between pathogens detected using quantitative polymerase chain reaction with airway inflammation in COPD at stable state and exacerbations

• Published in: Chest Vol. 147; no. 1; p. 46
• Main Authors: Barker, Bethan L, Haldar, Koirobi, Patel, Hemu, Pavord, Ian D, Barer, Michael R, Brightling, Christopher E, Bafadhel, Mona
• Format: Journal Article
• Language: English
• Published: United States 01.01.2015
• Subjects: Adult; Aged; Aged, 80 and over; Bacteria - genetics; Bacteria - isolation & purification; DNA, Bacterial - analysis; Female; Humans; Inflammation - microbiology; Male; Middle Aged; Polymerase Chain Reaction - methods; Pulmonary Disease, Chronic Obstructive - microbiology; Sputum - microbiology

Relationships between airway inflammation and respiratory potentially pathogenic microorganisms (PPMs) quantified using quantitative polymerase chain reaction (qPCR) in subjects with COPD are unclear. Our aim was to evaluate mediators of airway inflammation and their association with PPMs in subject...