The role of MAPK pathway in gastric cancer: unveiling molecular crosstalk and therapeutic prospects

• Published in: Journal of translational medicine Vol. 22; no. 1; pp. 1142 - 18
• Main Authors: Yuan, Weiwei, Shi, Yin, Dai, Shiping, Deng, Mao, Zhu, Kai, Xu, Yuanmin, Chen, Zhangming, Xu, Zhou, Zhang, Tianlong, Liang, Song
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.12.2024; BioMed Central; BMC
• Subjects: Analysis; Animals; Care and treatment; Diagnosis; Extracellular signal-regulated kinases; Gastric carcinogenesis; H. pylori and EBV-induced oncogenesis; Health aspects; Humans; MAP Kinase Signaling System; MicroRNAs - genetics; MicroRNAs - metabolism; miRNAs and lncRNAs; Mitogen-activated protein kinase signaling; Molecular dynamics; Review; Stomach cancer; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Stomach Neoplasms - therapy; Targeted therapy and molecular inhibitors; China; Gastric carcinogenesis; miRNAs and lncRNAs; Targeted therapy and molecular inhibitors; Mitogen-activated protein kinase signaling; H. pylori and EBV-induced oncogenesis

Gastric cancer remains a significant health burden globally, especially prevalent in Asian and European regions. Despite a notable decline in incidence in the United States and Western Europe over recent decades, the disease's persistence underscores the urgency for advanced research in its pat...