A Physiologically-Based Pharmacokinetic Model to Describe Ciprofloxacin Pharmacokinetics Over the Entire Span of Life

• Published in: Clinical pharmacokinetics Vol. 57; no. 12; pp. 1613 - 1634
• Main Authors: Schlender, Jan-Frederik, Teutonico, Donato, Coboeken, Katrin, Schnizler, Katrin, Eissing, Thomas, Willmann, Stefan, Jaehde, Ulrich, Stass, Heino
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2018; Springer Nature B.V
• Subjects: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Adults; Age; Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Antibiotics; Area Under Curve; Child; Child, Preschool; Ciprofloxacin - administration & dosage; Ciprofloxacin - pharmacokinetics; Clinical trials; Computer Simulation; Cystic fibrosis; Drug dosages; Drug therapy; Female; Geriatrics; Humans; Infant; Infant, Newborn; Internal Medicine; Male; Medicine; Medicine & Public Health; Metabolism; Metabolites; Middle Aged; Models, Biological; Original; Original Research Article; Patients; Pediatrics; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Physiology; Reproducibility of Results; Studies; Young Adult

Background Physiologically-based pharmacokinetic (PBPK) modeling has received growing interest as a useful tool for the assessment of drug pharmacokinetics by continuous knowledge integration. Objective The objective of this study was to build a ciprofloxacin PBPK model for intravenous and oral dosi...