Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells

• Published in: Oncogene Vol. 22; no. 25; pp. 3943 - 3951
• Main Authors: TAI YOUNG KIM, JONG, Hyun-Soon, SONG, Sang-Hyun, DIMTCHEV, Alexandre, JEONG, Sook-Jung, JUNG WEON LEE, KIM, Tae-You, NOE KYEONG KIM, JUNG, Mira, BANG, Yung-Jue
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 19.06.2003; Nature Publishing Group
• Subjects: Acetylation - drug effects; Acetyltransferases - antagonists & inhibitors; Alleles; Azacitidine - analogs & derivatives; Azacitidine - pharmacology; Azacytidine; Biological and medical sciences; Blotting, Northern; Blotting, Southern; Carcinogenesis; CpG Islands; DLC-1 gene; DNA methylation; DNA Methylation - drug effects; Enzyme Inhibitors - pharmacology; Epigenetics; Fundamental and applied biological sciences. Psychology; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic - physiology; Gene silencing; Gene Silencing - physiology; Genes; Genes, Tumor Suppressor; Genes. Genome; GTPase-Activating Proteins; Hepatocellular carcinoma; Histone Acetyltransferases; Histones - metabolism; Humans; Hydroxamic Acids - pharmacology; Internal medicine; Liver cancer; Medical research; Medicine; Molecular and cellular biology; Molecular genetics; Neoplasm Proteins - genetics; Protein Processing, Post-Translational - drug effects; Proteins; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; RNA, Neoplasm - biosynthesis; RNA, Neoplasm - genetics; Saccharomyces cerevisiae Proteins - antagonists & inhibitors; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Transcription factors; Trichostatin A; Tumor cell lines; Tumor Cells, Cultured - metabolism; Tumor suppressor genes; Tumor Suppressor Proteins - genetics; Tumors; University colleges; gastric cancer; Deacetylation; DLC-I; Epigenetics; histone deacetylation; Malignant tumor; Histone; Methylation; Mechanism; Tumor suppressor gene

DLC-1 (deleted in liver cancer) gene is frequently deleted in hepatocellular carcinoma. However, little is known about the genetic status and the expression of this gene in gastric cancer. In this study, Northern and Southern analysis showed that seven of nine human gastric cancer cell lines did not...