Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system

Cannabinoid receptor CB 2 (CB 2 R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, and ischemic stroke. The advent of positron emission...

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Published inActa pharmacologica Sinica Vol. 40; no. 3; pp. 351 - 357
Main Authors Ni, Ruiqing, Mu, Linjing, Ametamey, Simon
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 01.03.2019
Nature Publishing Group
Nature Publishing Group UK
Subjects
Amyotrophic lateral sclerosis
Animal models
Animals
Astrocytes
Biomedical and Life Sciences
Biomedicine
Brain - metabolism
Cannabinoid CB2 receptors
Central nervous system
Central Nervous System Diseases - diagnosis
Humans
Immunology
Inflammation
Inflammation - diagnosis
Internal Medicine
Ischemia
Medical imaging
Medical Microbiology
Microglia
Nervous system
Neuroimaging
Neurological diseases
Pharmacology/Toxicology
Positron emission tomography
Radioactive tracers
Radiopharmaceuticals - metabolism
Receptor, Cannabinoid, CB2 - metabolism
Review
Review Article
Tomography
Vaccine
cannabinoid receptor CB2
neurological diseases
positron emission tomography
inflammation
microglia
Online AccessGet full text

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Abstract Cannabinoid receptor CB 2 (CB 2 R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, and ischemic stroke. The advent of positron emission tomography (PET) using CB 2 R radiotracers has enabled the visualization of CB 2 R distribution in vivo in animal models of central nervous system inflammation, however translation to humans has been less successful. Several novel CB 2 R radiotracers have been developed and evaluated to quantify microglial activation. In this review, we summarize the recent preclinical and clinical imaging results of CB 2 R PET tracers and discuss the prospects of CB 2 R imaging using PET.
AbstractList Cannabinoid receptor CB 2 (CB 2 R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, and ischemic stroke. The advent of positron emission tomography (PET) using CB 2 R radiotracers has enabled the visualization of CB 2 R distribution in vivo in animal models of central nervous system inflammation, however translation to humans has been less successful. Several novel CB 2 R radiotracers have been developed and evaluated to quantify microglial activation. In this review, we summarize the recent preclinical and clinical imaging results of CB 2 R PET tracers and discuss the prospects of CB 2 R imaging using PET.
Cannabinoid receptor CB (CB R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis, and ischemic stroke. The advent of positron emission tomography (PET) using CB R radiotracers has enabled the visualization of CB R distribution in vivo in animal models of central nervous system inflammation, however translation to humans has been less successful. Several novel CB R radiotracers have been developed and evaluated to quantify microglial activation. In this review, we summarize the recent preclinical and clinical imaging results of CB R PET tracers and discuss the prospects of CB R imaging using PET.
Cannabinoid receptor CB2 (CB2R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis, and ischemic stroke. The advent of positron emission tomography (PET) using CB2R radiotracers has enabled the visualization of CB2R distribution in vivo in animal models of central nervous system inflammation, however translation to humans has been less successful. Several novel CB2R radiotracers have been developed and evaluated to quantify microglial activation. In this review, we summarize the recent preclinical and clinical imaging results of CB2R PET tracers and discuss the prospects of CB2R imaging using PET.
Author Mu, Linjing
Ni, Ruiqing
Ametamey, Simon
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Snippet Cannabinoid receptor CB 2 (CB 2 R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in...
Cannabinoid receptor CB (CB R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in...
Cannabinoid receptor CB2 (CB2R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in...
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StartPage 351
SubjectTerms Amyotrophic lateral sclerosis
Animal models
Animals
Astrocytes
Biomedical and Life Sciences
Biomedicine
Brain - metabolism
Cannabinoid CB2 receptors
Central nervous system
Central Nervous System Diseases - diagnosis
Humans
Immunology
Inflammation
Inflammation - diagnosis
Internal Medicine
Ischemia
Medical imaging
Medical Microbiology
Microglia
Nervous system
Neuroimaging
Neurological diseases
Pharmacology/Toxicology
Positron emission tomography
Radioactive tracers
Radiopharmaceuticals - metabolism
Receptor, Cannabinoid, CB2 - metabolism
Review
Review Article
Tomography
Vaccine
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Title Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system
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