Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system
Cannabinoid receptor CB 2 (CB 2 R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, and ischemic stroke. The advent of positron emission...
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Published in | Acta pharmacologica Sinica Vol. 40; no. 3; pp. 351 - 357 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Singapore
Springer Singapore
01.03.2019
Nature Publishing Group Nature Publishing Group UK |
Subjects | |
Online Access | Get full text |
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Abstract | Cannabinoid receptor CB
2
(CB
2
R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, and ischemic stroke. The advent of positron emission tomography (PET) using CB
2
R radiotracers has enabled the visualization of CB
2
R distribution in vivo in animal models of central nervous system inflammation, however translation to humans has been less successful. Several novel CB
2
R radiotracers have been developed and evaluated to quantify microglial activation. In this review, we summarize the recent preclinical and clinical imaging results of CB
2
R PET tracers and discuss the prospects of CB
2
R imaging using PET. |
---|---|
AbstractList | Cannabinoid receptor CB
2
(CB
2
R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, and ischemic stroke. The advent of positron emission tomography (PET) using CB
2
R radiotracers has enabled the visualization of CB
2
R distribution in vivo in animal models of central nervous system inflammation, however translation to humans has been less successful. Several novel CB
2
R radiotracers have been developed and evaluated to quantify microglial activation. In this review, we summarize the recent preclinical and clinical imaging results of CB
2
R PET tracers and discuss the prospects of CB
2
R imaging using PET. Cannabinoid receptor CB (CB R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis, and ischemic stroke. The advent of positron emission tomography (PET) using CB R radiotracers has enabled the visualization of CB R distribution in vivo in animal models of central nervous system inflammation, however translation to humans has been less successful. Several novel CB R radiotracers have been developed and evaluated to quantify microglial activation. In this review, we summarize the recent preclinical and clinical imaging results of CB R PET tracers and discuss the prospects of CB R imaging using PET. Cannabinoid receptor CB2 (CB2R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis, and ischemic stroke. The advent of positron emission tomography (PET) using CB2R radiotracers has enabled the visualization of CB2R distribution in vivo in animal models of central nervous system inflammation, however translation to humans has been less successful. Several novel CB2R radiotracers have been developed and evaluated to quantify microglial activation. In this review, we summarize the recent preclinical and clinical imaging results of CB2R PET tracers and discuss the prospects of CB2R imaging using PET. |
Author | Mu, Linjing Ni, Ruiqing Ametamey, Simon |
Author_xml | – sequence: 1 givenname: Ruiqing surname: Ni fullname: Ni, Ruiqing email: ni@biomed.ee.ethz.ch organization: Department of Chemistry and Applied Biosciences, Center for Radiopharmaceutical Sciences of ETH-PSI-USZ, Institute of Pharmaceutical Sciences, ETH Zurich – sequence: 2 givenname: Linjing surname: Mu fullname: Mu, Linjing organization: Department of Chemistry and Applied Biosciences, Center for Radiopharmaceutical Sciences of ETH-PSI-USZ, Institute of Pharmaceutical Sciences, ETH Zurich, Department of Nuclear Medicine, University Hospital Zurich – sequence: 3 givenname: Simon surname: Ametamey fullname: Ametamey, Simon organization: Department of Chemistry and Applied Biosciences, Center for Radiopharmaceutical Sciences of ETH-PSI-USZ, Institute of Pharmaceutical Sciences, ETH Zurich |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29921889$$D View this record in MEDLINE/PubMed |
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Keywords | cannabinoid receptor CB2 neurological diseases positron emission tomography inflammation microglia |
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Snippet | Cannabinoid receptor CB
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R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in... Cannabinoid receptor CB (CB R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in... Cannabinoid receptor CB2 (CB2R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in... |
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SubjectTerms | Amyotrophic lateral sclerosis Animal models Animals Astrocytes Biomedical and Life Sciences Biomedicine Brain - metabolism Cannabinoid CB2 receptors Central nervous system Central Nervous System Diseases - diagnosis Humans Immunology Inflammation Inflammation - diagnosis Internal Medicine Ischemia Medical imaging Medical Microbiology Microglia Nervous system Neuroimaging Neurological diseases Pharmacology/Toxicology Positron emission tomography Radioactive tracers Radiopharmaceuticals - metabolism Receptor, Cannabinoid, CB2 - metabolism Review Review Article Tomography Vaccine |
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Title | Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system |
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