The MUC5B promoter polymorphism is associated with idiopathic pulmonary fibrosis in a Mexican cohort but is rare among Asian ancestries

• Published in: Chest Vol. 147; no. 2; p. 460
• Main Authors: Peljto, Anna L, Selman, Moises, Kim, Dong Soon, Murphy, Elissa, Tucker, Laura, Pardo, Annie, Lee, Jung Su, Ji, Wonjun, Schwarz, Marvin I, Yang, Ivana V, Schwartz, David A, Fingerlin, Tasha E
• Format: Journal Article
• Language: English
• Published: United States 01.02.2015
• Subjects: Aged; Asian Continental Ancestry Group - genetics; European Continental Ancestry Group - genetics; Female; Genetic Association Studies; Genetic Variation; Humans; Idiopathic Pulmonary Fibrosis - ethnology; Idiopathic Pulmonary Fibrosis - genetics; Intracellular Signaling Peptides and Proteins - genetics; Logistic Models; Male; Mexico; Middle Aged; Mucin-5B - genetics; Republic of Korea; Signal Transduction - genetics; Mexico; Republic of Korea

Polymorphisms in the MUC5B promoter, TOLLIP, and nine additional genetic loci have been associated with idiopathic pulmonary fibrosis (IPF) within non-Hispanic white populations. It is unknown whether these variants account for risk of IPF in other racial/ethnic populations. We conducted a candidate...