Are Salivary and Plasma Levels of Toll‐Like Receptors 2 and 4 Elevated in Subjects With Chronic Periodontitis?: A Systematic Review and Meta‐Analysis

• Published in: International journal of inflammation Vol. 2025; no. 1; p. 7405066
• Main Authors: Alarcón-Sánchez, Mario Alberto, Rodríguez-Montaño, Ruth, Lomelí-Martínez, Sarah Monserrat, Martínez-Bugarin, Cristina Hermila, Mosaddad, Seyed Ali, Heboyan, Artak
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2025; Wiley
• Subjects: Analysis; Analytical chemistry; Antibiotics; Biomarkers; Clinical trials; Cross-sectional studies; Cytokines; Gum disease; Letters to the editor; Meta-analysis; Pattern recognition; Peptides; Periodontics; Periodontitis; Plasma; Proteins; Review; Systematic review; Tumor necrosis factor-TNF; Mexico; saliva; plasma; TLR4; biomarkers; periodontitis; TLR2

Toll‐like receptors (TLR2 and TLR4) are crucial in the detection of pathogen‐associated molecular patterns (PAMPs) during periodontitis, resulting in exacerbated production of proinflammatory cytokines and ultimately tissue damage and bone loss associated with this periodontal disease. This systemat...