Cytoprotective metal-organic frameworks for anaerobic bacteria

We report a strategy to uniformly wrap Morella thermoacetica bacteria with a metal-organic framework (MOF) monolayer of nanometer thickness for cytoprotection in artificial photosynthesis. The catalytic activity of the MOF enclosure toward decomposition of reactive oxygen species (ROS) reduces the d...

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Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 115; no. 42; pp. 10582 - 10587
Main Authors Ji, Zhe, Zhang, Hao, Liu, Hao, Yaghi, Omar M., Yang, Peidong
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 16.10.2018
National Academy of Sciences, Washington, DC (United States)
Subjects
Acetic acid
Anaerobic bacteria
artificial photosynthesis
Bacteria
BASIC BIOLOGICAL SCIENCES
Carbon dioxide
Carbon dioxide fixation
Carbon sequestration
Catalysis
Catalytic activity
Cell surface
Cell Survival
cell wrapping
Clusters
Cytoprotection
Decomposition
Decomposition reactions
Elongation
High definition
Metal-organic frameworks
Metal-Organic Frameworks - chemistry
Metals
Monolayers
Moorella - growth & development
Nanoparticles
Oxidative Stress
Photosynthesis
Physical Sciences
Reactive oxygen species
Surface Properties
Thickness
Zirconia
Zirconium
Zirconium - chemistry
Zirconium dioxide
artificial photosynthesis
anaerobic bacteria
cell wrapping
reactive oxygen species
metal-organic frameworks
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Summary:We report a strategy to uniformly wrap Morella thermoacetica bacteria with a metal-organic framework (MOF) monolayer of nanometer thickness for cytoprotection in artificial photosynthesis. The catalytic activity of the MOF enclosure toward decomposition of reactive oxygen species (ROS) reduces the death of strictly anaerobic bacteria by fivefold in the presence of 21% O₂, and enables the cytoprotected bacteria to continuously produce acetate from CO₂ fixation under oxidative stress. The high definition of the MOF–bacteria interface involving direct bonding between phosphate units on the cell surface and zirconium clusters on MOF monolayer, provides for enhancement of life throughout reproduction. The dynamic nature of the MOF wrapping allows for cell elongation and separation, including spontaneous covering of the newly grown cell surface. The open-metal sites on the zirconium clusters lead to 600 times more efficient ROS decomposition compared with zirconia nanoparticles.
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National Aeronautics and Space Administration (NASA)
AC02-05CH11231
USDOE Office of Science (SC)
1Z.J. and H.Z. contributed equally to this work.
Reviewers: J.C., Yonsei University; and W.R.D., Northwestern University.
Author contributions: Z.J., H.Z., O.M.Y., and P.Y. designed research; Z.J., H.Z., and H.L. performed research; Z.J., H.Z., and H.L. contributed new reagents/analytic tools; Z.J., H.Z., O.M.Y., and P.Y. analyzed data; and Z.J., H.Z., O.M.Y., and P.Y. wrote the paper.
Contributed by Peidong Yang, August 24, 2018 (sent for review June 4, 2018; reviewed by Jinwoo Cheon and William R. Dichtel)
ISSN:0027-8424
1091-6490
1091-6490
DOI:10.1073/pnas.1808829115