SIRT6 prevent chronic cerebral hypoperfusion induced cognitive impairment by remodeling mitochondrial dynamics in a STAT5-PGAM5-Drp1 dependent manner - Du, Yong; He, Jiaqing; Xu, Yanni; Wu, Xun; Cheng, Hongbo; Yu, Jiegang; Wang, Xiaoliang; An, Yaqing; Wu, Yang; Guo, Wei (Journal of translational medicine, 2024)
Keywords: Analysis; Animals; Brain Ischemia - complications; Brain Ischemia - metabolism; Brain Ischemia - pathology; Care and treatment; Carotid Stenosis - complications; Carotid Stenosis - metabolism; Chronic cerebral hypoperfusion; Chronic Disease; Cognition disorders; Cognitive Dysfunction - pathology; Cognitive impairment; Dementia; Diagnosis; Drp1; Dynamins - genetics; Dynamins - metabolism; Gene expression; Humans; Male; Mice; Mice, Inbred C57BL; Mitochondrial dynamics; Mitochondrial Dynamics - drug effects; Neurons; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Prevention; Risk factors; Signal Transduction - drug effects; SIRT6; Sirtuins - genetics; Sirtuins - metabolism; STAT5 Transcription Factor - metabolism; China; Chronic cerebral hypoperfusion; SIRT6; Mitochondrial dynamics; Cognitive impairment; Drp1