Induction of selective liver hypothermia prevents significant ischemia/reperfusion injury in Wistar rats after 24 hours

Purpose To investigate the effects of induction of selective liver hypothermia in a rodent model. Methods Seven male Wistar rats were subjected to 90 minutes of partial 70% liver ischemia and topic liver 26°C hypothermia (H group). Other seven male Wistar rats were subjected to 90 minutes of partial...

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Published inActa cirurgica brasileira Vol. 35; no. 2; p. e202000205
Main Authors Grezzana Filho, Tomaz de Jesus Maria, Longo, Larisse, Santos, Jorge Luiz Dos, Gabiatti, Gemerson, Boffil, Carlos, Santos, Emanuel Bendo Dos, Cerski, Carlos Thadeu Schmidt, Chedid, Marcio Fernandes, Corso, Carlos Otavio
Format Journal Article
LanguageEnglish
Published Brazil Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01.01.2020
Subjects
Cytokines
Hypothermia
Inflammation
Liver
Rats
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Abstract Purpose To investigate the effects of induction of selective liver hypothermia in a rodent model. Methods Seven male Wistar rats were subjected to 90 minutes of partial 70% liver ischemia and topic liver 26°C hypothermia (H group). Other seven male Wistar rats were subjected to 90 minutes of partial 70% normothermic liver ischemia (N group). Five additional rats underwent a midline incision and section of liver ligaments under normothermic conditions and without any liver ischemia (sham group). All animals were sacrificed 24-h after reperfusion, and livers were sampled for analyses. Pathology sections were scored for sinusoidal congestion, ballooning, hepatocelllular necrosis and the presence of neutrophilic infiltrates. Results At the end of the experiment, liver tissue expressions of TNF-ɑ, IL-1β, iNOS and TNF-ɑ/IL-10 ratio were significantly reduced in the H group compared to N group, whereas IL-10 and eNOS were significantly increased in H group. Histopathological injury scores revealed a significant decrease in ischemia/reperfusion (I/R) injuries in H group. Conclusion Selective liver hypothermia prevented I/R injury by inhibiting the release of inflammatory cytokines, preserves microcirculation, prevents hepatocellular necrosis and leukocyte infiltration, allowing maintenance of the liver architecture.
AbstractList Purpose To investigate the effects of induction of selective liver hypothermia in a rodent model. Methods Seven male Wistar rats were subjected to 90 minutes of partial 70% liver ischemia and topic liver 26°C hypothermia (H group). Other seven male Wistar rats were subjected to 90 minutes of partial 70% normothermic liver ischemia (N group). Five additional rats underwent a midline incision and section of liver ligaments under normothermic conditions and without any liver ischemia (sham group). All animals were sacrificed 24-h after reperfusion, and livers were sampled for analyses. Pathology sections were scored for sinusoidal congestion, ballooning, hepatocelllular necrosis and the presence of neutrophilic infiltrates. Results At the end of the experiment, liver tissue expressions of TNF-ɑ, IL-1β, iNOS and TNF-ɑ/IL-10 ratio were significantly reduced in the H group compared to N group, whereas IL-10 and eNOS were significantly increased in H group. Histopathological injury scores revealed a significant decrease in ischemia/reperfusion (I/R) injuries in H group. Conclusion Selective liver hypothermia prevented I/R injury by inhibiting the release of inflammatory cytokines, preserves microcirculation, prevents hepatocellular necrosis and leukocyte infiltration, allowing maintenance of the liver architecture.
Author Cerski, Carlos Thadeu Schmidt
Chedid, Marcio Fernandes
Santos, Jorge Luiz Dos
Corso, Carlos Otavio
Grezzana Filho, Tomaz de Jesus Maria
Longo, Larisse
Gabiatti, Gemerson
Santos, Emanuel Bendo Dos
Boffil, Carlos
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crossref_primary_10_3390_biomedicines12071475
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Snippet Purpose To investigate the effects of induction of selective liver hypothermia in a rodent model. Methods Seven male Wistar rats were subjected to 90 minutes...
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SubjectTerms Cytokines
Hypothermia
Inflammation
Liver
Rats
Title Induction of selective liver hypothermia prevents significant ischemia/reperfusion injury in Wistar rats after 24 hours
URI https://www.ncbi.nlm.nih.gov/pubmed/32428061
https://doaj.org/article/fdd4a8edf978491db84c3303cee10b4a
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