Feasibility of serum CGRP measurement as a biomarker of chronic migraine: a critical reappraisal

• Published in: Journal of headache and pain Vol. 19; no. 1; pp. 53 - 8
• Main Authors: Lee, Mi Ji, Lee, Sook-Yeon, Cho, Soohyun, Kang, Eun-Suk, Chung, Chin-Sang
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 13.07.2018; Springer Nature B.V; BMC
• Subjects: Adult; Biomarker; Biomarkers; Biomarkers - blood; Blood levels; Calcitonin; Calcitonin gene-related peptide; Calcitonin Gene-Related Peptide - blood; CGRP; Chronic Disease; Feasibility Studies; Female; Follow-Up Studies; Headache; Headache - blood; Headache - diagnosis; Headaches; Humans; Immunoassay; Internal Medicine; Male; Medicine; Medicine & Public Health; Middle Aged; Migraine; Migraine Disorders - blood; Migraine Disorders - diagnosis; Neurology; Pain Medicine; Patients; Peripheral blood; Prospective Studies; Research Article; Immunoassay; Biomarker; CGRP; Migraine

Background Calcitonin gene-related peptide (CGRP) has been reported as elevated in chronic migraine. We aimed to validate the role of interictal serum CGRP concentration in peripheral blood samples as a biomarker of chronic migraine. Methods We prospectively recruited patients with episodic and chro...