TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis

• Published in: Cell death & disease Vol. 10; no. 5; p. 328
• Main Authors: Li, Jie, Zhang, Jingyu, Zhang, Yusuo, Wang, Zichuang, Song, Yanmei, Wei, Shanwen, He, Meijun, You, Shoujiang, Jia, Jia, Cheng, Jian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.04.2019; Springer Nature B.V
• Subjects: 13/106; 13/51; 13/89; 14/19; 631/378/1689/534; 64/60; 692/699/375/534; 82/29; Amino Acid Chloromethyl Ketones - pharmacology; Animal models; Animals; Antibodies; Apoptosis; Biochemistry; Biomedical and Life Sciences; Brain - metabolism; Brain - pathology; Brain injury; Brain tumors; Caspase inhibitors; Cell activation; Cell Biology; Cell Culture; Cell death; Cell Hypoxia; Cell size; Cells, Cultured; Cerebral blood flow; Cerebral infarction; Culture Media, Conditioned - pharmacology; Disease Models, Animal; GTPase-Activating Proteins - metabolism; Hippocampus; Immunology; Infarction, Middle Cerebral Artery - complications; Infarction, Middle Cerebral Artery - pathology; Inflammation; Ischemia; Life Sciences; Male; Mice; Mice, Inbred ICR; Microglia; Microglia - cytology; Microglia - metabolism; Necroptosis; Necroptosis - drug effects; Neostriatum; Polymerase chain reaction; Protein Kinases - metabolism; Reperfusion; Reperfusion Injury - etiology; Reperfusion Injury - pathology; RNA Interference; RNA, Small Interfering - metabolism; Stroke; TNF Receptor-Associated Factor 2 - antagonists & inhibitors; TNF Receptor-Associated Factor 2 - genetics; TNF Receptor-Associated Factor 2 - metabolism; TRAF2 protein; Traumatic brain injury; Tumor Necrosis Factor-alpha - pharmacology; Tumor necrosis factor-TNF; Tumor necrosis factor-α

Necroptosis contributes to ischemia-induced brain injury. Tumor necrosis factor (TNF) receptor associated factor 2 (TRAF2) has been reported to suppress necroptotic cell death under several pathological conditions. In this study, we investigated the role of TRAF2 in experimental stroke using a mouse...