Efficacy and safety of sublingual tablets of house dust mite allergen extracts: Results of a dose-ranging study in an environmental exposure chamber

• Published in: Journal of allergy and clinical immunology Vol. 138; no. 2; pp. 451 - 458.e5
• Main Authors: Roux, Michel, Devillier, Philippe, Yang, William H., Montagut, Armelle, Abiteboul, Kathy, Viatte, Agnès, Zeldin, Robert K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2016; Elsevier Limited
• Subjects: Adult; Allergen immunotherapy; allergic rhinitis; Allergies; Allergy and Immunology; Antigens, Dermatophagoides - administration & dosage; Antigens, Dermatophagoides - immunology; Area Under Curve; Asthma; Dermatophagoides pteronyssinus; dose-ranging; double-blind placebo-controlled trial; Environmental Exposure; environmental exposure chamber; Female; Forced Expiratory Volume; house dust mite; Humans; Immunoglobulin E - immunology; Immunoglobulin G - immunology; Immunotherapy; Investigations; Male; Nose; Rhinitis, Allergic - diagnosis; Rhinitis, Allergic - immunology; Rhinitis, Allergic - therapy; Sublingual Immunotherapy - adverse effects; Sublingual Immunotherapy - methods; sublingual immunotherapy tablet; Treatment Outcome; Young Adult; dose-ranging; EEC; house dust mite; AE; RTSS; double-blind placebo-controlled trial; IR; VAS; environmental exposure chamber; AIT; ARSS; AUC; ChBL; AVASS; HDM; sublingual immunotherapy tablet; TEAE; ARTSS; allergic rhinitis; Allergen immunotherapy; Average Rhinitis Symptom Score; Visual Analog Scale; Index of reactivity; Rhinitis Total Symptom Score; Area under the curve; Ch BL; Average Rhinitis Total Symptom Score; Average Visual Analog Scale Score; Change from baseline; Adverse event; Treatment-emergent adverse event

In a natural field study, sublingual tablets of house dust mite (HDM) allergen extracts (STG320) were efficacious in treating HDM-associated allergic rhinitis. We sought to assess the efficacy and safety of 3 doses of STG320 in an environmental exposure chamber. In this randomized, double-blind stud...