Chromosome substitution strain assessment of a Huntington’s disease modifier locus

Huntington’s disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans are now revealing chromosome regions that contain disease-modifying genes. We have explored a novel human–mouse cross-species functional prior...

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Published inMammalian genome Vol. 26; no. 3-4; pp. 119 - 130
Main Authors Ramos, Eliana Marisa, Kovalenko, Marina, Guide, Jolene R., St. Claire, Jason, Gillis, Tammy, Mysore, Jayalakshmi S., Sequeiros, Jorge, Wheeler, Vanessa C., Alonso, Isabel, MacDonald, Marcy E.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.04.2015
Springer Nature B.V
Subjects
Alleles
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Body Weight
Cell Biology
chromosome substitution
Chromosomes, Human
Chromosomes, Mammalian
Crosses, Genetic
crossing
Disease Models, Animal
Dopamine and cAMP-Regulated Phosphoprotein 32 - genetics
Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism
Female
Gene Knock-In Techniques
genes
Genetic Variation
Genomic Instability
Genotype
Human Genetics
Humans
Huntingtin Protein
Huntington Disease - genetics
Life Sciences
liver
loci
Male
Mice
Mice, Transgenic
Mutation
Nerve Tissue Proteins - genetics
neurodegenerative diseases
Neurons - metabolism
Phenotype
progeny
Quantitative Trait Loci
Trinucleotide Repeats
weight gain
Mutant Huntingtin
Somatic Instability
Intranuclear Inclusion
Repeat Instability
Chromosome Substitution Strain
Online AccessGet full text

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Abstract Huntington’s disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans are now revealing chromosome regions that contain disease-modifying genes. We have explored a novel human–mouse cross-species functional prioritisation approach, by evaluating the HD modifier 6q23–24 linkage interval. This unbiased strategy employs C57BL/6J (B6J) Hdh Q111 knock-in mice, replicates of the HD mutation, and the C57BL/6J-chr10 A/J /NaJ chromosome substitution strain (CSS10), in which only chromosome 10 (chr10), in synteny with the human 6q23–24 region, is derived from the A/J (AJ) strain. Crosses were performed to assess the possibility of dominantly acting chr10 AJ-B6J variants of strong effect that may modulate CAG-dependent Hdh Q111/+ phenotypes. Testing of F1 progeny confirmed that a single AJ chromosome had a significant effect on the rate of body weight gain and in Hdh Q111 mice the AJ chromosome was associated subtle alterations in somatic CAG instability in the liver and the formation of intra-nuclear inclusions, as well as DARPP-32 levels, in the striatum. These findings in relatively small cohorts are suggestive of dominant chr10 AJ-B6 variants that may modify effects of the CAG expansion, and encourage a larger study with CSS10 and sub-strains. This cross-species approach may therefore be suited to functional in vivo prioritisation of genomic regions harbouring genes that can modify the early effects of the HD mutation.
AbstractList Huntington's disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans are now revealing chromosome regions that contain disease-modifying genes. We have explored a novel human-mouse cross-species functional prioritisation approach, by evaluating the HD modifier 6q23-24 linkage interval. This unbiased strategy employs C57BL/6J (B6J) Hdh^sup Q111^ knock-in mice, replicates of the HD mutation, and the C57BL/6J-chr10^sup A/J^/NaJ chromosome substitution strain (CSS10), in which only chromosome 10 (chr10), in synteny with the human 6q23-24 region, is derived from the A/J (AJ) strain. Crosses were performed to assess the possibility of dominantly acting chr10 AJ-B6J variants of strong effect that may modulate CAG-dependent Hdh^sup Q111/+^ phenotypes. Testing of F1 progeny confirmed that a single AJ chromosome had a significant effect on the rate of body weight gain and in Hdh^sup Q111^ mice the AJ chromosome was associated subtle alterations in somatic CAG instability in the liver and the formation of intra-nuclear inclusions, as well as DARPP-32 levels, in the striatum. These findings in relatively small cohorts are suggestive of dominant chr10 AJ-B6 variants that may modify effects of the CAG expansion, and encourage a larger study with CSS10 and sub-strains. This cross-species approach may therefore be suited to functional in vivo prioritisation of genomic regions harbouring genes that can modify the early effects of the HD mutation.
Huntington’s disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans are now revealing chromosome regions that contain disease-modifying genes. We have explored a novel human–mouse cross-species functional prioritisation approach, by evaluating the HD modifier 6q23–24 linkage interval. This unbiased strategy employs C57BL/6J (B6J) Hdh Q111 knock-in mice, replicates of the HD mutation, and the C57BL/6J-chr10 A/J /NaJ chromosome substitution strain (CSS10), in which only chromosome 10 (chr10), in synteny with the human 6q23–24 region, is derived from the A/J (AJ) strain. Crosses were performed to assess the possibility of dominantly acting chr10 AJ-B6J variants of strong effect that may modulate CAG-dependent Hdh Q111/+ phenotypes. Testing of F1 progeny confirmed that a single AJ chromosome had a significant effect on the rate of body weight gain and in Hdh Q111 mice the AJ chromosome was associated subtle alterations in somatic CAG instability in the liver and the formation of intra-nuclear inclusions, as well as DARPP-32 levels, in the striatum. These findings in relatively small cohorts are suggestive of dominant chr10 AJ-B6 variants that may modify effects of the CAG expansion, and encourage a larger study with CSS10 and sub-strains. This cross-species approach may therefore be suited to functional in vivo prioritisation of genomic regions harbouring genes that can modify the early effects of the HD mutation.
Huntington’s disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans are now revealing chromosome regions that contain disease-modifying genes. We have explored a novel human–mouse cross-species functional prioritisation approach, by evaluating the HD modifier 6q23–24 linkage interval. This unbiased strategy employs C57BL/6J (B6J) HdhQ¹¹¹knock-in mice, replicates of the HD mutation, and the C57BL/6J-chr10ᴬ/ᴶ/NaJ chromosome substitution strain (CSS10), in which only chromosome 10 (chr10), in synteny with the human 6q23–24 region, is derived from the A/J (AJ) strain. Crosses were performed to assess the possibility of dominantly acting chr10 AJ-B6J variants of strong effect that may modulate CAG-dependent HdhQ¹¹¹/⁺phenotypes. Testing of F1 progeny confirmed that a single AJ chromosome had a significant effect on the rate of body weight gain and in HdhQ¹¹¹mice the AJ chromosome was associated subtle alterations in somatic CAG instability in the liver and the formation of intra-nuclear inclusions, as well as DARPP-32 levels, in the striatum. These findings in relatively small cohorts are suggestive of dominant chr10 AJ-B6 variants that may modify effects of the CAG expansion, and encourage a larger study with CSS10 and sub-strains. This cross-species approach may therefore be suited to functional in vivo prioritisation of genomic regions harbouring genes that can modify the early effects of the HD mutation.
Huntington's disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans are now revealing chromosome regions that contain disease-modifying genes. We have explored a novel human-mouse cross-species functional prioritisation approach, by evaluating the HD modifier 6q23-24 linkage interval. This unbiased strategy employs C57BL/6J (B6J) Hdh(Q111) knock-in mice, replicates of the HD mutation, and the C57BL/6J-chr10(A/J)/NaJ chromosome substitution strain (CSS10), in which only chromosome 10 (chr10), in synteny with the human 6q23-24 region, is derived from the A/J (AJ) strain. Crosses were performed to assess the possibility of dominantly acting chr10 AJ-B6J variants of strong effect that may modulate CAG-dependent Hdh(Q111/+) phenotypes. Testing of F1 progeny confirmed that a single AJ chromosome had a significant effect on the rate of body weight gain and in Hdh(Q111) mice the AJ chromosome was associated subtle alterations in somatic CAG instability in the liver and the formation of intra-nuclear inclusions, as well as DARPP-32 levels, in the striatum. These findings in relatively small cohorts are suggestive of dominant chr10 AJ-B6 variants that may modify effects of the CAG expansion, and encourage a larger study with CSS10 and sub-strains. This cross-species approach may therefore be suited to functional in vivo prioritisation of genomic regions harbouring genes that can modify the early effects of the HD mutation.
Huntington's disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans are now revealing chromosome regions that contain disease-modifying genes. We have explored a novel human-mouse cross-species functional prioritisation approach, by evaluating the HD modifier 6q23-24 linkage interval. This unbiased strategy employs C57BL/6J (B6J) Hdh(Q111) knock-in mice, replicates of the HD mutation, and the C57BL/6J-chr10(A/J)/NaJ chromosome substitution strain (CSS10), in which only chromosome 10 (chr10), in synteny with the human 6q23-24 region, is derived from the A/J (AJ) strain. Crosses were performed to assess the possibility of dominantly acting chr10 AJ-B6J variants of strong effect that may modulate CAG-dependent Hdh(Q111/+) phenotypes. Testing of F1 progeny confirmed that a single AJ chromosome had a significant effect on the rate of body weight gain and in Hdh(Q111) mice the AJ chromosome was associated subtle alterations in somatic CAG instability in the liver and the formation of intra-nuclear inclusions, as well as DARPP-32 levels, in the striatum. These findings in relatively small cohorts are suggestive of dominant chr10 AJ-B6 variants that may modify effects of the CAG expansion, and encourage a larger study with CSS10 and sub-strains. This cross-species approach may therefore be suited to functional in vivo prioritisation of genomic regions harbouring genes that can modify the early effects of the HD mutation.Huntington's disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans are now revealing chromosome regions that contain disease-modifying genes. We have explored a novel human-mouse cross-species functional prioritisation approach, by evaluating the HD modifier 6q23-24 linkage interval. This unbiased strategy employs C57BL/6J (B6J) Hdh(Q111) knock-in mice, replicates of the HD mutation, and the C57BL/6J-chr10(A/J)/NaJ chromosome substitution strain (CSS10), in which only chromosome 10 (chr10), in synteny with the human 6q23-24 region, is derived from the A/J (AJ) strain. Crosses were performed to assess the possibility of dominantly acting chr10 AJ-B6J variants of strong effect that may modulate CAG-dependent Hdh(Q111/+) phenotypes. Testing of F1 progeny confirmed that a single AJ chromosome had a significant effect on the rate of body weight gain and in Hdh(Q111) mice the AJ chromosome was associated subtle alterations in somatic CAG instability in the liver and the formation of intra-nuclear inclusions, as well as DARPP-32 levels, in the striatum. These findings in relatively small cohorts are suggestive of dominant chr10 AJ-B6 variants that may modify effects of the CAG expansion, and encourage a larger study with CSS10 and sub-strains. This cross-species approach may therefore be suited to functional in vivo prioritisation of genomic regions harbouring genes that can modify the early effects of the HD mutation.
Huntington's disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans are now revealing chromosome regions that contain disease-modifying genes. We have explored a novel human-mouse cross-species functional prioritisation approach, by evaluating the HD modifier 6q23-24 linkage interval. This unbiased strategy employs C57BL/6J (B6J) Hdh super(Q111) knock-in mice, replicates of the HD mutation, and the C57BL/6J-chr10 super(A/J)/NaJ chromosome substitution strain (CSS10), in which only chromosome 10 (chr10), in synteny with the human 6q23-24 region, is derived from the A/J (AJ) strain. Crosses were performed to assess the possibility of dominantly acting chr10 AJ-B6J variants of strong effect that may modulate CAG-dependent Hdh super(Q111/+) phenotypes. Testing of F1 progeny confirmed that a single AJ chromosome had a significant effect on the rate of body weight gain and in Hdh super(Q111) mice the AJ chromosome was associated subtle alterations in somatic CAG instability in the liver and the formation of intra-nuclear inclusions, as well as DARPP-32 levels, in the striatum. These findings in relatively small cohorts are suggestive of dominant chr10 AJ-B6 variants that may modify effects of the CAG expansion, and encourage a larger study with CSS10 and sub-strains. This cross-species approach may therefore be suited to functional in vivo prioritisation of genomic regions harbouring genes that can modify the early effects of the HD mutation.
Author Kovalenko, Marina
Guide, Jolene R.
Gillis, Tammy
Mysore, Jayalakshmi S.
St. Claire, Jason
Ramos, Eliana Marisa
Alonso, Isabel
MacDonald, Marcy E.
Sequeiros, Jorge
Wheeler, Vanessa C.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/25645993$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1007_s11064_015_1772_1
crossref_primary_10_3233_JHD_170282
crossref_primary_10_1371_journal_pone_0134465
Cites_doi 10.1093/hmg/11.6.633
10.1212/01.wnl.0000334276.09729.0e
10.1093/nar/gkr974
10.1016/j.nut.2003.10.007
10.1038/ng1297-404
10.1001/archneur.1991.00530200036015
10.1038/ng0893-387
10.1038/ng0893-398
10.1186/gm80
10.1111/j.1468-1331.2006.01319.x
10.1186/1752-0509-4-29
10.1002/gepi.20317
10.1038/nmeth.2089
10.1007/s10048-004-0175-2
10.1038/ng0893-393
10.1038/73427
10.1016/j.neuroscience.2008.08.041
10.1086/378133
10.1097/00001756-200011270-00032
10.1093/hmg/9.4.503
10.1073/pnas.120166397
10.1212/WNL.0b013e3181b04aa2
10.1016/j.stem.2012.04.027
10.1093/hmg/ddg169
10.1073/pnas.0308679101
10.1016/j.nbd.2009.05.007
10.1002/ajmg.1320210213
10.1097/00005072-198511000-00003
10.1093/hmg/ddl125
10.1093/hmg/8.1.115
10.1186/1471-2350-7-71
10.1016/0092-8674(93)90585-E
10.1212/01.WNL.0000031791.10922.CF
10.1371/journal.pone.0023647
10.1093/hmg/10.2.137
10.1097/00005072-199805000-00001
10.1126/science.1093139
10.1093/hmg/ddg056
10.1371/journal.pone.0080923
10.1007/s00335-010-9247-9
10.1093/nar/gks1236
10.1093/ajcn/50.1.145
10.5694/j.1326-5377.1981.tb135681.x
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Springer Science+Business Media New York 2015
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Issue 3-4
Keywords Mutant Huntingtin
Somatic Instability
Intranuclear Inclusion
Repeat Instability
Chromosome Substitution Strain
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
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References Eppig, Blake, Bult, Kadin, Richardson (CR8) 2012; 40
Hickey, Kosmalska, Enayati, Cohen, Zeitlin, Levine, Chesselet (CR13) 2008; 157
Schneider, Rasband, Eliceiri (CR28) 2012; 9
Lee, Pinto, Gillis, St Claire, Wheeler (CR16) 2011; 6
Wexler, Lorimer, Porter, Gomez, Moskowitz, Shackell, Marder, Penchaszadeh, Roberts, Gayan, Brocklebank, Cherny, Cardon, Gray, Dlouhy, Wiktorski, Hodes, Conneally, Penney, Gusella, Cha, Irizarry, Rosas, Hersch, Hollingsworth, MacDonald, Young, Andresen, Housman, De Young, Bonilla, Stillings, Negrette, Snodgrass, Martinez-Jaurrieta, Ramos-Arroyo, Bickham, Ramos, Marshall, Shoulson, Rey, Feigin, Arnheim, Acevedo-Cruz, Acosta, Alvir, Fischbeck, Thompson, Young, Dure, O’Brien, Paulsen, Brickman, Krch, Peery, Hogarth, Higgins, Landwehrmeyer (CR38) 2004; 101
Flicek, Ahmed, Amode, Barrell, Beal, Brent, Carvalho-Silva, Clapham, Coates, Fairley, Fitzgerald, Gil, Garcia-Giron, Gordon, Hourlier, Hunt, Juettemann, Kahari, Keenan, Komorowska, Kulesha, Longden, Maurel, McLaren, Muffato, Nag, Overduin, Pignatelli, Pritchard, Pritchard, Riat, Ritchie, Ruffier, Schuster, Sheppard, Sobral, Taylor, Thormann, Trevanion, White, Wilder, Aken, Birney, Cunningham, Dunham, Harrow, Herrero, Hubbard, Johnson, Kinsella, Parker, Spudich, Yates, Zadissa, Searle (CR10) 2013; 41
Nadeau, Singer, Matin, Lander (CR25) 2000; 24
Wheeler, Auerbach, White, Srinidhi, Auerbach, Ryan, Duyao, Vrbanac, Weaver, Gusella, Joyner, MacDonald (CR39) 1999; 8
Wheeler, White, Gutekunst, Vrbanac, Weaver, Li, Li, Yi, Vonsattel, Gusella, Hersch, Auerbach, Joyner, MacDonald (CR40) 2000; 9
Burrage, Baskin-Hill, Sinasac, Singer, Croniger, Kirby, Kulbokas, Daly, Lander, Broman, Nadeau (CR4) 2010; 21
Morales, Estevez, Suarez, Villalobos, Chacin de Bonilla, Bonilla (CR23) 1989; 50
Trejo, Tarrats, Alonso, Boll, Ochoa, Velasquez (CR34) 2004; 20
(CR32) 2012; 11
Aziz, van der Burg, Landwehrmeyer, Brundin, Stijnen, Roos (CR2) 2008; 71
Duyao, Ambrose, Myers, Novelletto, Persichetti, Frontali, Folstein, Ross, Franz, Abbott (CR7) 1993; 4
Bibb, Yan, Svenningsson, Snyder, Pieribone, Horiuchi, Nairn, Messer, Greengard (CR3) 2000; 97
Snell, MacMillan, Cheadle, Fenton, Lazarou, Davies, MacDonald, Gusella, Harper, Shaw (CR31) 1993; 4
White, Auerbach, Duyao, Vonsattel, Gusella, Joyner, MacDonald (CR43) 1997; 17
Andrew, Goldberg, Kremer, Telenius, Theilmann, Adam, Starr, Squitieri, Lin, Kalchman (CR1) 1993; 4
Lloret, Dragileva, Teed, Espinola, Fossale, Gillis, Lopez, Myers, MacDonald, Wheeler (CR20) 2006; 15
Sanberg, Fibiger, Mark (CR27) 1981; 1
Lin, Tallaksen-Greene, Chien, Cearley, Jackson, Crouse, Ren, Li, Albin, Detloff (CR19) 2001; 10
Li, Hayden, Almqvist, Brinkman, Durr, Dode, Morrison, Suchowersky, Ross, Margolis, Rosenblatt, Gomez-Tortosa, Cabrero, Novelletto, Frontali, Nance, Trent, McCusker, Jones, Paulsen, Harrison, Zanko, Abramson, Russ, Knowlton, Djousse, Mysore, Tariot, Gusella, Wheeler, Atwood, Cupples, Saint-Hilaire, Cha, Hersch, Koroshetz, Gusella, MacDonald, Myers (CR17) 2003; 73
Farrer, Yu (CR9) 1985; 21
Myers, Sax, Koroshetz, Mastromauro, Cupples, Kiely, Pettengill, Bird (CR24) 1991; 48
Djousse, Knowlton, Cupples, Marder, Shoulson, Myers (CR5) 2002; 59
(CR33) 1993; 72
Wheeler, Lebel, Vrbanac, Teed, te Riele, MacDonald (CR42) 2003; 12
Menalled, El-Khodor, Patry, Suarez-Farinas, Orenstein, Zahasky, Leahy, Wheeler, Yang, MacDonald, Morton, Bates, Leeds, Park, Howland, Signer, Tobin, Brunner (CR22) 2009; 35
Holter, Stromberg, Kovalenko, Garrett, Glasl, Lopez, Guide, Gotz, Hans, Becker, Rathkolb, Rozman, Schrewed, Klingenspor, Klopstock, Schulz, Wolf, Wursta, Gillis, Wakimoto, Seidman, MacDonald, Cotman, Gailus-Durner, Fuchs, de Angelis, Lee, Wheeler (CR14) 2013; 8
Slow, van Raamsdonk, Rogers, Coleman, Graham, Deng, Oh, Bissada, Hossain, Yang, Li, Simpson, Gutekunst, Leavitt, Hayden (CR30) 2003; 12
Vonsattel, DiFiglia (CR36) 1998; 57
Marder, Zhao, Eberly, Tanner, Oakes, Shoulson (CR21) 2009; 73
Vonsattel, Myers, Stevens, Ferrante, Bird, Richardson (CR37) 1985; 44
Wheeler, Gutekunst, Vrbanac, Lebel, Schilling, Hersch, Friedlander, Gusella, Vonsattel, Borchelt, MacDonald (CR41) 2002; 11
van Dellen, Welch, Dixon, Cordery, York, Styles, Blakemore, Hannan (CR35) 2000; 11
Gusella, MacDonald (CR12) 2009; 1
Singer, Hill, Burrage, Olszens, Song, Justice, O’Brien, Conti, Witte, Lander, Nadeau (CR29) 2004; 304
Lee, Zhang, Su, Walker, Wiltshire, Kang, Dragileva, Gillis, Lopez, Boily, Cyr, Kohane, Gusella, MacDonald, Wheeler (CR15) 2010; 4
Li, Hayden, Warby, Durr, Morrison, Nance, Ross, Margolis, Rosenblatt, Squitieri, Frati, Gomez-Tortosa, Garcia, Suchowersky, Klimek, Trent, McCusker, Novelletto, Frontali, Paulsen, Jones, Ashizawa, Lazzarini, Wheeler, Prakash, Xu, Djousse, Mysore, Gillis, Hakky, Cupples, Saint-Hilaire, Cha, Hersch, Penney, Harrison, Perlman, Zanko, Abramson, Lechich, Duckett, Marder, Conneally, Gusella, MacDonald, Myers (CR18) 2006; 7
Robbins, Ho, Barker (CR26) 2006; 13
Djousse, Knowlton, Hayden, Almqvist, Brinkman, Ross, Margolis, Rosenblatt, Durr, Dode, Morrison, Novelletto, Frontali, Trent, McCusker, Gomez-Tortosa, Mayo Cabrero, Jones, Zanko, Nance, Abramson, Suchowersky, Paulsen, Harrison, Yang, Cupples, Mysore, Gusella, MacDonald, Myers (CR6) 2004; 5
Gayan, Brocklebank, Andresen, Alkorta-Aranburu, Zameel Cader, Roberts, Cherny, Wexler, Cardon, Housman (CR11) 2008; 32
L Menalled (9552_CR22) 2009; 35
RG Snell (9552_CR31) 1993; 4
NA Aziz (9552_CR2) 2008; 71
JP Vonsattel (9552_CR37) 1985; 44
M Duyao (9552_CR7) 1993; 4
JF Gusella (9552_CR12) 2009; 1
VC Wheeler (9552_CR42) 2003; 12
JM Lee (9552_CR16) 2011; 6
JL Li (9552_CR17) 2003; 73
JT Eppig (9552_CR8) 2012; 40
PR Sanberg (9552_CR27) 1981; 1
JL Li (9552_CR18) 2006; 7
JB Singer (9552_CR29) 2004; 304
EJ Slow (9552_CR30) 2003; 12
JM Lee (9552_CR15) 2010; 4
VC Wheeler (9552_CR39) 1999; 8
L Djousse (9552_CR5) 2002; 59
P Flicek (9552_CR10) 2013; 41
K Marder (9552_CR21) 2009; 73
RH Myers (9552_CR24) 1991; 48
NS Wexler (9552_CR38) 2004; 101
SE Andrew (9552_CR1) 1993; 4
L Djousse (9552_CR6) 2004; 5
VC Wheeler (9552_CR40) 2000; 9
CA Schneider (9552_CR28) 2012; 9
JH Nadeau (9552_CR25) 2000; 24
A Trejo (9552_CR34) 2004; 20
J Gayan (9552_CR11) 2008; 32
LC Burrage (9552_CR4) 2010; 21
JK White (9552_CR43) 1997; 17
LM Morales (9552_CR23) 1989; 50
AO Robbins (9552_CR26) 2006; 13
JA Bibb (9552_CR3) 2000; 97
SM Holter (9552_CR14) 2013; 8
The HD iPSC Consortium (9552_CR32) 2012; 11
MA Hickey (9552_CR13) 2008; 157
LA Farrer (9552_CR9) 1985; 21
VC Wheeler (9552_CR41) 2002; 11
The Huntington’s Disease Collaborative Research Group (9552_CR33) 1993; 72
A Dellen van (9552_CR35) 2000; 11
JP Vonsattel (9552_CR36) 1998; 57
CH Lin (9552_CR19) 2001; 10
A Lloret (9552_CR20) 2006; 15
12427878 - Neurology. 2002 Nov 12;59(9):1325-30
21897851 - PLoS One. 2011;6(8):e23647
18981372 - Neurology. 2008 Nov 4;71(19):1506-13
18805465 - Neuroscience. 2008 Nov 11;157(1):280-95
6454826 - Med J Aust. 1981 Apr 18;1(8):407-9
14993615 - Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3498-503
24278347 - PLoS One. 2013;8(11):e80923
15031436 - Science. 2004 Apr 16;304(5669):445-8
15029481 - Neurogenetics. 2004 Jun;5(2):109-14
10700173 - Nat Genet. 2000 Mar;24(3):221-5
22075990 - Nucleic Acids Res. 2012 Jan;40(Database issue):D881-6
2932539 - J Neuropathol Exp Neurol. 1985 Nov;44(6):559-77
20302627 - BMC Syst Biol. 2010;4:29
19464370 - Neurobiol Dis. 2009 Sep;35(3):319-36
16879284 - Eur J Neurol. 2006 Aug;13(8):e7
22930834 - Nat Methods. 2012 Jul;9(7):671-5
12812983 - Hum Mol Genet. 2003 Jul 1;12(13):1555-67
22748968 - Cell Stem Cell. 2012 Aug 3;11(2):264-78
23203987 - Nucleic Acids Res. 2013 Jan;41(Database issue):D48-55
12900792 - Am J Hum Genet. 2003 Sep;73(3):682-7
9596408 - J Neuropathol Exp Neurol. 1998 May;57(5):369-84
19725930 - Genome Med. 2009 Aug 21;1(8):80
8401587 - Nat Genet. 1993 Aug;4(4):387-92
2526577 - Am J Clin Nutr. 1989 Jul;50(1):145-50
14962685 - Nutrition. 2004 Feb;20(2):192-6
18481795 - Genet Epidemiol. 2008 Jul;32(5):445-53
10699173 - Hum Mol Genet. 2000 Mar 1;9(4):503-13
9887339 - Hum Mol Genet. 1999 Jan;8(1):115-22
11117485 - Neuroreport. 2000 Nov 27;11(17):3751-7
11152661 - Hum Mol Genet. 2001 Jan 15;10(2):137-44
16687439 - Hum Mol Genet. 2006 Jun 15;15(12):2015-24
19652143 - Neurology. 2009 Aug 4;73(5):385-92
3160237 - Am J Med Genet. 1985 Jun;21(2):307-16
12554681 - Hum Mol Genet. 2003 Feb 1;12(3):273-81
1832854 - Arch Neurol. 1991 Aug;48(8):800-4
9398841 - Nat Genet. 1997 Dec;17(4):404-10
11912178 - Hum Mol Genet. 2002 Mar 15;11(6):633-40
8401588 - Nat Genet. 1993 Aug;4(4):393-7
8401589 - Nat Genet. 1993 Aug;4(4):398-403
8458085 - Cell. 1993 Mar 26;72(6):971-83
10829080 - Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6809-14
20127486 - Mamm Genome. 2010 Apr;21(3-4):115-29
16914060 - BMC Med Genet. 2006;7:71
References_xml – volume: 11
  start-page: 633
  year: 2002
  end-page: 640
  ident: CR41
  article-title: Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/11.6.633
– volume: 71
  start-page: 1506
  year: 2008
  end-page: 1513
  ident: CR2
  article-title: Weight loss in Huntington disease increases with higher CAG repeat number
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000334276.09729.0e
– volume: 40
  start-page: D881
  year: 2012
  end-page: D886
  ident: CR8
  article-title: The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkr974
– volume: 20
  start-page: 192
  year: 2004
  end-page: 196
  ident: CR34
  article-title: Assessment of the nutrition status of patients with Huntington’s disease
  publication-title: Nutrition
  doi: 10.1016/j.nut.2003.10.007
– volume: 17
  start-page: 404
  year: 1997
  end-page: 410
  ident: CR43
  article-title: Huntingtin is required for neurogenesis and is not impaired by the Huntington’s disease CAG expansion
  publication-title: Nat Genet
  doi: 10.1038/ng1297-404
– volume: 48
  start-page: 800
  year: 1991
  end-page: 804
  ident: CR24
  article-title: Factors associated with slow progression in Huntington’s disease
  publication-title: Arch Neurol
  doi: 10.1001/archneur.1991.00530200036015
– volume: 4
  start-page: 387
  year: 1993
  end-page: 392
  ident: CR7
  article-title: Trinucleotide repeat length instability and age of onset in Huntington’s disease
  publication-title: Nat Genet
  doi: 10.1038/ng0893-387
– volume: 4
  start-page: 398
  year: 1993
  end-page: 403
  ident: CR1
  article-title: The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington’s disease
  publication-title: Nat Genet
  doi: 10.1038/ng0893-398
– volume: 1
  start-page: 80
  year: 2009
  ident: CR12
  article-title: Huntington’s disease: the case for genetic modifiers
  publication-title: Genome Med
  doi: 10.1186/gm80
– volume: 13
  start-page: e7
  year: 2006
  ident: CR26
  article-title: Weight changes in Huntington’s disease
  publication-title: Eur J Neurol
  doi: 10.1111/j.1468-1331.2006.01319.x
– volume: 4
  start-page: 29
  year: 2010
  ident: CR15
  article-title: A novel approach to investigate tissue-specific trinucleotide repeat instability
  publication-title: BMC Syst Biol
  doi: 10.1186/1752-0509-4-29
– volume: 32
  start-page: 445
  year: 2008
  end-page: 453
  ident: CR11
  article-title: Genomewide linkage scan reveals novel loci modifying age of onset of Huntington’s disease in the Venezuelan HD kindreds
  publication-title: Genet Epidemiol
  doi: 10.1002/gepi.20317
– volume: 9
  start-page: 671
  year: 2012
  end-page: 675
  ident: CR28
  article-title: NIH Image to ImageJ: 25 years of image analysis
  publication-title: Nat Methods
  doi: 10.1038/nmeth.2089
– volume: 50
  start-page: 145
  year: 1989
  end-page: 150
  ident: CR23
  article-title: Nutritional evaluation of Huntington disease patients
  publication-title: Am J Clin Nutr
– volume: 5
  start-page: 109
  year: 2004
  end-page: 114
  ident: CR6
  article-title: Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16
  publication-title: Neurogenetics
  doi: 10.1007/s10048-004-0175-2
– volume: 4
  start-page: 393
  year: 1993
  end-page: 397
  ident: CR31
  article-title: Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington’s disease
  publication-title: Nat Genet
  doi: 10.1038/ng0893-393
– volume: 24
  start-page: 221
  year: 2000
  end-page: 225
  ident: CR25
  article-title: Analysing complex genetic traits with chromosome substitution strains
  publication-title: Nat Genet
  doi: 10.1038/73427
– volume: 157
  start-page: 280
  year: 2008
  end-page: 295
  ident: CR13
  article-title: Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington’s disease mice
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2008.08.041
– volume: 73
  start-page: 682
  year: 2003
  end-page: 687
  ident: CR17
  article-title: A genome scan for modifiers of age at onset in Huntington disease: the HD MAPS study
  publication-title: Am J Hum Genet
  doi: 10.1086/378133
– volume: 11
  start-page: 3751
  year: 2000
  end-page: 3757
  ident: CR35
  article-title: N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington’s disease mice
  publication-title: NeuroReport
  doi: 10.1097/00001756-200011270-00032
– volume: 9
  start-page: 503
  year: 2000
  end-page: 513
  ident: CR40
  article-title: Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/9.4.503
– volume: 97
  start-page: 6809
  year: 2000
  end-page: 6814
  ident: CR3
  article-title: Severe deficiencies in dopamine signaling in presymptomatic Huntington’s disease mice
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.120166397
– volume: 73
  start-page: 385
  year: 2009
  end-page: 392
  ident: CR21
  article-title: Dietary intake in adults at risk for Huntington disease: analysis of PHAROS research participants
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e3181b04aa2
– volume: 11
  start-page: 264
  year: 2012
  end-page: 278
  ident: CR32
  article-title: Induced pluripotent stem cells from patients with Huntington’s disease show CAG-repeat-expansion-associated phenotypes
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2012.04.027
– volume: 12
  start-page: 1555
  year: 2003
  end-page: 1567
  ident: CR30
  article-title: Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddg169
– volume: 101
  start-page: 3498
  year: 2004
  end-page: 3503
  ident: CR38
  article-title: Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington’s disease age of onset
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0308679101
– volume: 35
  start-page: 319
  year: 2009
  end-page: 336
  ident: CR22
  article-title: Systematic behavioral evaluation of Huntington’s disease transgenic and knock-in mouse models
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2009.05.007
– volume: 21
  start-page: 307
  year: 1985
  end-page: 316
  ident: CR9
  article-title: Anthropometric discrimination among affected, at-risk, and not-at-risk individuals in families with Huntington disease
  publication-title: Am J Med Genet
  doi: 10.1002/ajmg.1320210213
– volume: 44
  start-page: 559
  year: 1985
  end-page: 577
  ident: CR37
  article-title: Neuropathological classification of Huntington’s disease
  publication-title: J Neuropathol Exp Neurol
  doi: 10.1097/00005072-198511000-00003
– volume: 15
  start-page: 2015
  year: 2006
  end-page: 2024
  ident: CR20
  article-title: Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington’s disease knock-in mice
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddl125
– volume: 8
  start-page: 115
  year: 1999
  end-page: 122
  ident: CR39
  article-title: Length-dependent gametic CAG repeat instability in the Huntington’s disease knock-in mouse
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/8.1.115
– volume: 7
  start-page: 71
  year: 2006
  ident: CR18
  article-title: Genome-wide significance for a modifier of age at neurological onset in Huntington’s disease at 6q23-24: the HD MAPS study
  publication-title: BMC Med Genet
  doi: 10.1186/1471-2350-7-71
– volume: 1
  start-page: 407
  year: 1981
  end-page: 409
  ident: CR27
  article-title: Body weight and dietary factors in Huntington’s disease patients compared with matched controls
  publication-title: Med J Aust
– volume: 72
  start-page: 971
  year: 1993
  end-page: 983
  ident: CR33
  article-title: A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes
  publication-title: Cell
  doi: 10.1016/0092-8674(93)90585-E
– volume: 59
  start-page: 1325
  year: 2002
  end-page: 1330
  ident: CR5
  article-title: Weight loss in early stage of Huntington’s disease
  publication-title: Neurology
  doi: 10.1212/01.WNL.0000031791.10922.CF
– volume: 6
  start-page: e23647
  year: 2011
  ident: CR16
  article-title: Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0023647
– volume: 10
  start-page: 137
  year: 2001
  end-page: 144
  ident: CR19
  article-title: Neurological abnormalities in a knock-in mouse model of Huntington’s disease
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/10.2.137
– volume: 57
  start-page: 369
  year: 1998
  end-page: 384
  ident: CR36
  article-title: Huntington disease
  publication-title: J Neuropathol Exp Neurol
  doi: 10.1097/00005072-199805000-00001
– volume: 304
  start-page: 445
  year: 2004
  end-page: 448
  ident: CR29
  article-title: Genetic dissection of complex traits with chromosome substitution strains of mice
  publication-title: Science
  doi: 10.1126/science.1093139
– volume: 12
  start-page: 273
  year: 2003
  end-page: 281
  ident: CR42
  article-title: Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddg056
– volume: 8
  start-page: e80923
  year: 2013
  ident: CR14
  article-title: A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington’s disease CAG knock-in mice
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0080923
– volume: 21
  start-page: 115
  year: 2010
  end-page: 129
  ident: CR4
  article-title: Genetic resistance to diet-induced obesity in chromosome substitution strains of mice
  publication-title: Mamm Genome
  doi: 10.1007/s00335-010-9247-9
– volume: 41
  start-page: D48
  year: 2013
  end-page: D55
  ident: CR10
  article-title: Ensembl 2013
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gks1236
– volume: 50
  start-page: 145
  year: 1989
  ident: 9552_CR23
  publication-title: Am J Clin Nutr
  doi: 10.1093/ajcn/50.1.145
– volume: 17
  start-page: 404
  year: 1997
  ident: 9552_CR43
  publication-title: Nat Genet
  doi: 10.1038/ng1297-404
– volume: 32
  start-page: 445
  year: 2008
  ident: 9552_CR11
  publication-title: Genet Epidemiol
  doi: 10.1002/gepi.20317
– volume: 73
  start-page: 682
  year: 2003
  ident: 9552_CR17
  publication-title: Am J Hum Genet
  doi: 10.1086/378133
– volume: 73
  start-page: 385
  year: 2009
  ident: 9552_CR21
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e3181b04aa2
– volume: 1
  start-page: 407
  year: 1981
  ident: 9552_CR27
  publication-title: Med J Aust
  doi: 10.5694/j.1326-5377.1981.tb135681.x
– volume: 57
  start-page: 369
  year: 1998
  ident: 9552_CR36
  publication-title: J Neuropathol Exp Neurol
  doi: 10.1097/00005072-199805000-00001
– volume: 11
  start-page: 3751
  year: 2000
  ident: 9552_CR35
  publication-title: NeuroReport
  doi: 10.1097/00001756-200011270-00032
– volume: 11
  start-page: 633
  year: 2002
  ident: 9552_CR41
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/11.6.633
– volume: 4
  start-page: 387
  year: 1993
  ident: 9552_CR7
  publication-title: Nat Genet
  doi: 10.1038/ng0893-387
– volume: 35
  start-page: 319
  year: 2009
  ident: 9552_CR22
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2009.05.007
– volume: 157
  start-page: 280
  year: 2008
  ident: 9552_CR13
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2008.08.041
– volume: 7
  start-page: 71
  year: 2006
  ident: 9552_CR18
  publication-title: BMC Med Genet
  doi: 10.1186/1471-2350-7-71
– volume: 20
  start-page: 192
  year: 2004
  ident: 9552_CR34
  publication-title: Nutrition
  doi: 10.1016/j.nut.2003.10.007
– volume: 24
  start-page: 221
  year: 2000
  ident: 9552_CR25
  publication-title: Nat Genet
  doi: 10.1038/73427
– volume: 13
  start-page: e7
  year: 2006
  ident: 9552_CR26
  publication-title: Eur J Neurol
  doi: 10.1111/j.1468-1331.2006.01319.x
– volume: 21
  start-page: 307
  year: 1985
  ident: 9552_CR9
  publication-title: Am J Med Genet
  doi: 10.1002/ajmg.1320210213
– volume: 97
  start-page: 6809
  year: 2000
  ident: 9552_CR3
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.120166397
– volume: 48
  start-page: 800
  year: 1991
  ident: 9552_CR24
  publication-title: Arch Neurol
  doi: 10.1001/archneur.1991.00530200036015
– volume: 59
  start-page: 1325
  year: 2002
  ident: 9552_CR5
  publication-title: Neurology
  doi: 10.1212/01.WNL.0000031791.10922.CF
– volume: 71
  start-page: 1506
  year: 2008
  ident: 9552_CR2
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000334276.09729.0e
– volume: 8
  start-page: e80923
  year: 2013
  ident: 9552_CR14
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0080923
– volume: 72
  start-page: 971
  year: 1993
  ident: 9552_CR33
  publication-title: Cell
  doi: 10.1016/0092-8674(93)90585-E
– volume: 101
  start-page: 3498
  year: 2004
  ident: 9552_CR38
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0308679101
– volume: 6
  start-page: e23647
  year: 2011
  ident: 9552_CR16
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0023647
– volume: 15
  start-page: 2015
  year: 2006
  ident: 9552_CR20
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddl125
– volume: 12
  start-page: 1555
  year: 2003
  ident: 9552_CR30
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddg169
– volume: 12
  start-page: 273
  year: 2003
  ident: 9552_CR42
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddg056
– volume: 1
  start-page: 80
  year: 2009
  ident: 9552_CR12
  publication-title: Genome Med
  doi: 10.1186/gm80
– volume: 4
  start-page: 393
  year: 1993
  ident: 9552_CR31
  publication-title: Nat Genet
  doi: 10.1038/ng0893-393
– volume: 44
  start-page: 559
  year: 1985
  ident: 9552_CR37
  publication-title: J Neuropathol Exp Neurol
  doi: 10.1097/00005072-198511000-00003
– volume: 9
  start-page: 503
  year: 2000
  ident: 9552_CR40
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/9.4.503
– volume: 9
  start-page: 671
  year: 2012
  ident: 9552_CR28
  publication-title: Nat Methods
  doi: 10.1038/nmeth.2089
– volume: 304
  start-page: 445
  year: 2004
  ident: 9552_CR29
  publication-title: Science
  doi: 10.1126/science.1093139
– volume: 4
  start-page: 398
  year: 1993
  ident: 9552_CR1
  publication-title: Nat Genet
  doi: 10.1038/ng0893-398
– volume: 5
  start-page: 109
  year: 2004
  ident: 9552_CR6
  publication-title: Neurogenetics
  doi: 10.1007/s10048-004-0175-2
– volume: 10
  start-page: 137
  year: 2001
  ident: 9552_CR19
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/10.2.137
– volume: 11
  start-page: 264
  year: 2012
  ident: 9552_CR32
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2012.04.027
– volume: 40
  start-page: D881
  year: 2012
  ident: 9552_CR8
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkr974
– volume: 41
  start-page: D48
  year: 2013
  ident: 9552_CR10
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gks1236
– volume: 4
  start-page: 29
  year: 2010
  ident: 9552_CR15
  publication-title: BMC Syst Biol
  doi: 10.1186/1752-0509-4-29
– volume: 8
  start-page: 115
  year: 1999
  ident: 9552_CR39
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/8.1.115
– volume: 21
  start-page: 115
  year: 2010
  ident: 9552_CR4
  publication-title: Mamm Genome
  doi: 10.1007/s00335-010-9247-9
– reference: 19464370 - Neurobiol Dis. 2009 Sep;35(3):319-36
– reference: 18805465 - Neuroscience. 2008 Nov 11;157(1):280-95
– reference: 16914060 - BMC Med Genet. 2006;7:71
– reference: 11912178 - Hum Mol Genet. 2002 Mar 15;11(6):633-40
– reference: 18981372 - Neurology. 2008 Nov 4;71(19):1506-13
– reference: 14962685 - Nutrition. 2004 Feb;20(2):192-6
– reference: 6454826 - Med J Aust. 1981 Apr 18;1(8):407-9
– reference: 20302627 - BMC Syst Biol. 2010;4:29
– reference: 10700173 - Nat Genet. 2000 Mar;24(3):221-5
– reference: 9596408 - J Neuropathol Exp Neurol. 1998 May;57(5):369-84
– reference: 8401589 - Nat Genet. 1993 Aug;4(4):398-403
– reference: 18481795 - Genet Epidemiol. 2008 Jul;32(5):445-53
– reference: 16879284 - Eur J Neurol. 2006 Aug;13(8):e7
– reference: 10699173 - Hum Mol Genet. 2000 Mar 1;9(4):503-13
– reference: 12812983 - Hum Mol Genet. 2003 Jul 1;12(13):1555-67
– reference: 11117485 - Neuroreport. 2000 Nov 27;11(17):3751-7
– reference: 2526577 - Am J Clin Nutr. 1989 Jul;50(1):145-50
– reference: 12900792 - Am J Hum Genet. 2003 Sep;73(3):682-7
– reference: 21897851 - PLoS One. 2011;6(8):e23647
– reference: 15031436 - Science. 2004 Apr 16;304(5669):445-8
– reference: 8401588 - Nat Genet. 1993 Aug;4(4):393-7
– reference: 3160237 - Am J Med Genet. 1985 Jun;21(2):307-16
– reference: 9887339 - Hum Mol Genet. 1999 Jan;8(1):115-22
– reference: 8458085 - Cell. 1993 Mar 26;72(6):971-83
– reference: 2932539 - J Neuropathol Exp Neurol. 1985 Nov;44(6):559-77
– reference: 20127486 - Mamm Genome. 2010 Apr;21(3-4):115-29
– reference: 12554681 - Hum Mol Genet. 2003 Feb 1;12(3):273-81
– reference: 1832854 - Arch Neurol. 1991 Aug;48(8):800-4
– reference: 11152661 - Hum Mol Genet. 2001 Jan 15;10(2):137-44
– reference: 8401587 - Nat Genet. 1993 Aug;4(4):387-92
– reference: 23203987 - Nucleic Acids Res. 2013 Jan;41(Database issue):D48-55
– reference: 12427878 - Neurology. 2002 Nov 12;59(9):1325-30
– reference: 19725930 - Genome Med. 2009 Aug 21;1(8):80
– reference: 22075990 - Nucleic Acids Res. 2012 Jan;40(Database issue):D881-6
– reference: 24278347 - PLoS One. 2013;8(11):e80923
– reference: 22748968 - Cell Stem Cell. 2012 Aug 3;11(2):264-78
– reference: 14993615 - Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3498-503
– reference: 16687439 - Hum Mol Genet. 2006 Jun 15;15(12):2015-24
– reference: 10829080 - Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6809-14
– reference: 9398841 - Nat Genet. 1997 Dec;17(4):404-10
– reference: 15029481 - Neurogenetics. 2004 Jun;5(2):109-14
– reference: 22930834 - Nat Methods. 2012 Jul;9(7):671-5
– reference: 19652143 - Neurology. 2009 Aug 4;73(5):385-92
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Snippet Huntington’s disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans...
Huntington's disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans...
Huntington’s disease (HD) is a dominant neurodegenerative disorder that is due to expansion of an unstable HTT CAG repeat for which genome-wide genetic scans...
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proquest
pubmed
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springer
SourceType Open Access Repository
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Enrichment Source
Publisher
StartPage 119
SubjectTerms Alleles
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Body Weight
Cell Biology
chromosome substitution
Chromosomes, Human
Chromosomes, Mammalian
Crosses, Genetic
crossing
Disease Models, Animal
Dopamine and cAMP-Regulated Phosphoprotein 32 - genetics
Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism
Female
Gene Knock-In Techniques
genes
Genetic Variation
Genomic Instability
Genotype
Human Genetics
Humans
Huntingtin Protein
Huntington Disease - genetics
Life Sciences
liver
loci
Male
Mice
Mice, Transgenic
Mutation
Nerve Tissue Proteins - genetics
neurodegenerative diseases
Neurons - metabolism
Phenotype
progeny
Quantitative Trait Loci
Trinucleotide Repeats
weight gain
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Title Chromosome substitution strain assessment of a Huntington’s disease modifier locus
URI https://link.springer.com/article/10.1007/s00335-014-9552-9
https://www.ncbi.nlm.nih.gov/pubmed/25645993
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Volume 26
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