Blood–brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging

• Published in: Brain imaging and behavior Vol. 13; no. 2; pp. 389 - 395
• Main Authors: Zhang, C. Eleana, Wong, Sau May, Uiterwijk, Renske, Backes, Walter H., Jansen, Jacobus F. A., Jeukens, Cécile R. L. P. N., van Oostenbrugge, Robert J., Staals, Julie
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2019; Springer Nature B.V
• Subjects: Aged; Aging; Aging - metabolism; Attention deficit hyperactivity disorder; Biomedical and Life Sciences; Biomedicine; Blood-brain barrier; Blood-Brain Barrier - diagnostic imaging; Blood-Brain Barrier - physiopathology; Brain; Cerebral Small Vessel Diseases - diagnostic imaging; Cerebral Small Vessel Diseases - physiopathology; Cognition; Cognition & reasoning; Cognitive ability; Cortex; Data processing; Executive function; Female; Gray Matter - diagnostic imaging; Gray Matter - physiopathology; Humans; Information processing; Leakage; Magnetic Resonance Imaging; Male; Neuropsychology; Neuroradiology; Neurosciences; Original Research; Patients; Psychiatry; Substantia alba; Substantia grisea; Vascular diseases; White Matter - diagnostic imaging; White Matter - physiopathology; White matter hyperintensities; Cognition; MRI; Cerebral small vessel disease; Blood–brain barrier

Blood–brain barrier (BBB) leakage increases with age and is involved in the pathophysiology of cerebral small vessel disease (cSVD). We examined the relationship between BBB leakage and white matter hyperintensity (WMH) volume and cognition, in cSVD patients and healthy controls. Seventy-seven patie...