Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen - Pallesen, Jesper; Wang, Nianshuang; Corbett, Kizzmekia S.; Wrapp, Daniel; Kirchdoerfer, Robert N.; Turner, Hannah L.; Cottrell, Christopher A.; Becker, Michelle M.; Wang, Lingshu; Shi, Wei; Kong, Wing-Pui; Andres, Erica L.; et al. (Proceedings of the National Academy of Sciences - PNAS, 2017)
Keywords: Animals; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Antigens; BASIC BIOLOGICAL SCIENCES; Binding; Biological Sciences; Conformation; Coronaviridae; Coronaviridae - immunology; coronavirus; Coronavirus Infections - virology; Coronaviruses; COVID-19; cryo-EM; Crystallography; Crystallography, X-Ray - methods; Glycoproteins; Human populations; Humans; Immune response; Immune response (humoral); Immune system; Immunity, Humoral - immunology; Immunogenicity; Immunoglobulin G - metabolism; Immunoglobulins; Membrane fusion; Mice, Inbred BALB C; Middle East Respiratory Syndrome Coronavirus - immunology; Mortality; Neutralizing; neutralizing antibody; Outbreaks; peplomer; PNAS Plus; Protein Binding; Protein Conformation; Proteins; Receptors, Virus - metabolism; Respiratory diseases; Spike Glycoprotein, Coronavirus - immunology; Structure-Activity Relationship; Studies; Vaccination; Vaccines; Viral Vaccines - immunology; X-ray; X-rays; X-ray crystallography; peplomer; coronavirus; neutralizing antibody; cryo-EM