Transcranial Focused Ultrasound Neuromodulation: A Review of the Excitatory and Inhibitory Effects on Brain Activity in Human and Animals
Non-invasive neuromodulation technology is important for the treatment of brain diseases. The effects of focused ultrasound on neuronal activity have been investigated since the 1920s. Low intensity transcranial focused ultrasound (tFUS) can exert non-destructive mechanical pressure effects on cellu...
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| Published in | Frontiers in human neuroscience Vol. 15; p. 749162 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Lausanne
Frontiers Research Foundation
28.09.2021
Frontiers Media S.A |
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| Abstract | Non-invasive neuromodulation technology is important for the treatment of brain diseases. The effects of focused ultrasound on neuronal activity have been investigated since the 1920s. Low intensity transcranial focused ultrasound (tFUS) can exert non-destructive mechanical pressure effects on cellular membranes and ion channels and has been shown to modulate the activity of peripheral nerves, spinal reflexes, the cortex, and even deep brain nuclei, such as the thalamus. It has obvious advantages in terms of security and spatial selectivity. This technology is considered to have broad application prospects in the treatment of neurodegenerative disorders and neuropsychiatric disorders. This review synthesizes animal and human research outcomes and offers an integrated description of the excitatory and inhibitory effects of tFUS in varying experimental and disease conditions. |
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| AbstractList | Non-invasive neuromodulation technology is important for the treatment of brain diseases. The effects of focused ultrasound on neuronal activity have been investigated since the 1920s. Low intensity transcranial focused ultrasound (tFUS) can exert non-destructive mechanical pressure effects on cellular membranes and ion channels and has been shown to modulate the activity of peripheral nerves, spinal reflexes, the cortex, and even deep brain nuclei, such as the thalamus. It has obvious advantages in terms of security and spatial selectivity. This technology is considered to have broad application prospects in the treatment of neurodegenerative disorders and neuropsychiatric disorders. This review synthesizes animal and human research outcomes and offers an integrated description of the excitatory and inhibitory effects of tFUS in varying experimental and disease conditions.Non-invasive neuromodulation technology is important for the treatment of brain diseases. The effects of focused ultrasound on neuronal activity have been investigated since the 1920s. Low intensity transcranial focused ultrasound (tFUS) can exert non-destructive mechanical pressure effects on cellular membranes and ion channels and has been shown to modulate the activity of peripheral nerves, spinal reflexes, the cortex, and even deep brain nuclei, such as the thalamus. It has obvious advantages in terms of security and spatial selectivity. This technology is considered to have broad application prospects in the treatment of neurodegenerative disorders and neuropsychiatric disorders. This review synthesizes animal and human research outcomes and offers an integrated description of the excitatory and inhibitory effects of tFUS in varying experimental and disease conditions. Non-invasive neuromodulation technology is important for the treatment of brain diseases. The effects of focused ultrasound on neuronal activity have been investigated since the 1920s. Low intensity transcranial focused ultrasound (tFUS) can exert non-destructive mechanical pressure effects on cellular membranes and ion channels and has been shown to modulate the activity of peripheral nerves, spinal reflexes, the cortex, and even deep brain nuclei, such as the thalamus. It has obvious advantages in terms of security and spatial selectivity. This technology is considered to have broad application prospects in the treatment of neurodegenerative disorders and neuropsychiatric disorders. This review synthesizes animal and human research outcomes and offers an integrated description of the excitatory and inhibitory effects of tFUS in varying experimental and disease conditions. Improved methods for noninvasively modulating human brain function are needed. The effects of focused ultrasound on neuronal activity have been investigated since the 1920s. FUS has been shown to modulate the activity of peripheral nerves, spinal reflexes, the cortex, and even deep brain nuclei, such as the thalamus. Unlike high-intensity ultrasound, low-intensity transcranial focused ultrasound (tFUS) can exert nondestructive mechanical pressure effects on cellular membranes and ion channels without producing cavitation and thermal injury. Therefore, it has obvious advantages in terms of security. This technology is considered to have broad application prospects in brain diseases such as neurodegenerative disorders and neuropsychiatric disorders. This review synthesizes animal and human research outcomes and offers an integrated description of the excitatory and inhibitory effects of tFUS in varying experimental and disease conditions. |
| Author | Wang, Yuping Hu, Shimin Zhang, Tingting Liu, Chunyan Pan, Na |
| AuthorAffiliation | 1 Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing , China 3 Center of Epilepsy, Institute of Sleep and Consciousness Disorders, Beijing Institute for Brain Disorders, Capital Medical University , Beijing , China 2 Beijing Key Laboratory of Neuromodulation , Beijing , China |
| AuthorAffiliation_xml | – name: 2 Beijing Key Laboratory of Neuromodulation , Beijing , China – name: 3 Center of Epilepsy, Institute of Sleep and Consciousness Disorders, Beijing Institute for Brain Disorders, Capital Medical University , Beijing , China – name: 1 Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing , China |
| Author_xml | – sequence: 1 givenname: Tingting surname: Zhang fullname: Zhang, Tingting – sequence: 2 givenname: Na surname: Pan fullname: Pan, Na – sequence: 3 givenname: Yuping surname: Wang fullname: Wang, Yuping – sequence: 4 givenname: Chunyan surname: Liu fullname: Liu, Chunyan – sequence: 5 givenname: Shimin surname: Hu fullname: Hu, Shimin |
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| Copyright | 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2021 Zhang, Pan, Wang, Liu and Hu. Copyright © 2021 Zhang, Pan, Wang, Liu and Hu. 2021 Zhang, Pan, Wang, Liu and Hu |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Edited by: Jiaojian Wang, University of Electronic Science and Technology of China, China Reviewed by: Xiaojing Long, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS), China; Li Wang, Beijing Institute of Technology, China This article was submitted to Brain Imaging and Stimulation, a section of the journal Frontiers in Human Neuroscience |
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| Snippet | Non-invasive neuromodulation technology is important for the treatment of brain diseases. The effects of focused ultrasound on neuronal activity have been... Improved methods for noninvasively modulating human brain function are needed. The effects of focused ultrasound on neuronal activity have been investigated... |
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| SubjectTerms | Ablation animal Animals Brain research Cavitation Cell membranes human Ion channels Mental disorders Neurodegenerative diseases Neuromodulation Neuroscience non-invasive brain stimulation Peripheral nerves Reflexes Thalamus Thermal injury transcranial focused ultrasound Ultrasonic imaging Ultrasound |
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| Title | Transcranial Focused Ultrasound Neuromodulation: A Review of the Excitatory and Inhibitory Effects on Brain Activity in Human and Animals |
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