NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer

• Published in: Molecular cancer Vol. 23; no. 1; pp. 139 - 16
• Main Authors: Yu, Min, Ni, Mengdong, Xu, Fei, Liu, Chaohua, Chen, Lihua, Li, Jiana, Xia, Siyu, Diao, Yixin, Chen, Jiaxin, Zhu, Jun, Wu, Xiaohua, Tang, Min, Li, Jiajia, Ke, Guihao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.07.2024; BioMed Central; BMC
• Subjects: 3D bioprinted patient-derived organoid; 5-Methylcytosine - analogs & derivatives; 5-Methylcytosine - metabolism; Analysis; Animals; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Line, Tumor; Cervical cancer; DNA; Drug resistance; Ethylenediaminetetraacetic acid; Female; Gene Expression Regulation, Neoplastic; Genes; Humans; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Liquid chromatography; m5C modification; Mass spectrometry; Messenger RNA; Methyltransferases - genetics; Methyltransferases - metabolism; Mice; NSUN6; Prognosis; Radiation; Radiation Tolerance - genetics; Radioresistance; RNA sequencing; RNA, Messenger - genetics; RNA, Messenger - metabolism; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - radiotherapy; Xenograft Model Antitumor Assays; China; Radioresistance; 3D bioprinted patient-derived organoid; NSUN6; Cervical cancer; m5C modification

Radioresistance is the leading cause of death in advanced cervical cancer (CC). Dysregulation of RNA modification has recently emerged as a regulatory mechanism in radiation and drug resistance. We aimed to explore the biological function and clinical significance of 5-methylcytosine (m C) in cervic...