Regulation of microRNA biogenesis and turnover by animals and their viruses

• Published in: Cellular and molecular life sciences : CMLS Vol. 70; no. 19; pp. 3525 - 3544
• Main Authors: Libri, Valentina, Miesen, Pascal, van Rij, Ronald P., Buck, Amy H.
• Format: Journal Article
• Language: English
• Published: Basel Springer Basel 01.10.2013; Springer Nature B.V
• Subjects: Animal diseases; Animals; Biochemistry; biogenesis; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell size; Gene Expression; Humans; Life Sciences; microRNA; MicroRNAs; MicroRNAs - biosynthesis; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; non-coding RNA; protein synthesis; Proteins; regulator genes; Review; Ribonucleic acid; RNA; RNA interference; RNA viruses; RNA-mediated interference; Signal transduction; siRNA; small interfering RNA; Suppressors; Viral infections; viral proteins; Viruses; Viruses - genetics; Viruses - metabolism; MicroRNA; Host–pathogen; RNA degradation; Herpesviruses; Viral suppressor of RNA interference; MicroRNA turnover; MicroRNA biogenesis

MicroRNAs (miRNAs) are a ubiquitous component of gene regulatory networks that modulate the precise amounts of proteins expressed in a cell. Despite their small size, miRNA genes contain various recognition elements that enable specificity in when, where and to what extent they are expressed. The im...