Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury

• Published in: Cell death and differentiation Vol. 27; no. 1; pp. 210 - 226
• Main Authors: Lv, Lin-Li, Feng, Ye, Wu, Min, Wang, Bin, Li, Zuo-Lin, Zhong, Xin, Wu, Wei-Jun, Chen, Jun, Ni, Hai-Feng, Tang, Tao-Tao, Tang, Ri-Ning, Lan, Hui-Yao, Liu, Bi-Cheng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2020; Nature Publishing Group
• Subjects: 13/109; 13/51; 13/89; 14/1; 14/19; 14/28; 14/34; 38/61; 38/90; 42/41; 631/208/2490; 64/60; 692/420/256/2515; 692/699/1585; 96/21; Acute Kidney Injury - genetics; Acute Kidney Injury - metabolism; Adult; Aged; Animals; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cell activation; Cell Biology; Cell Cycle Analysis; Cells, Cultured; Diabetic Nephropathies - urine; Diabetic nephropathy; Epithelial cells; Epithelial Cells - metabolism; Exosomes - genetics; Exosomes - metabolism; Female; Humans; Inflammation; Kidney - metabolism; Kidney - pathology; Kidney diseases; Kidney Tubules - metabolism; Life Sciences; Macrophage Activation; Macrophages; Macrophages - metabolism; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; MicroRNAs; MicroRNAs - metabolism; MicroRNAs - urine; Middle Aged; miRNA; Nephritis - genetics; Nephritis - pathology; NF-kappa B - metabolism; Proteinuria - chemically induced; Proteinuria - genetics; Proteinuria - metabolism; RAW 264.7 Cells; Stem Cells; Suppressor of Cytokine Signaling 1 Protein - genetics; Suppressor of Cytokine Signaling 1 Protein - metabolism

Tubulointerstitial inflammation is a common characteristic of acute and chronic kidney injury. However, the mechanism by which the initial injury of tubular epithelial cells (TECs) drives interstitial inflammation remains unclear. This paper aims to explore the role of exosomal miRNAs derived from T...