Molecular stratification of early breast cancer identifies drug targets to drive stratified medicine

• Published in: NPJ breast cancer Vol. 3; no. 1; pp. 3 - 10
• Main Authors: Bayani, Jane, Yao, Cindy Q., Quintayo, Mary Anne, Yan, Fu, Haider, Syed, D’Costa, Alister, Brookes, Cassandra L., van de Velde, Cornelis J. H., Hasenburg, Annette, Kieback, Dirk G., Markopoulos, Christos, Dirix, Luc, Seynaeve, Caroline, Rea, Daniel, Boutros, Paul C., Bartlett, John M. S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.02.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67/1347; 692/53/2422; Biomedical and Life Sciences; Biomedicine; Breast cancer; Cancer Research; Cancer therapies; Cell Biology; Cell cycle; Chemotherapy; Endocrine therapy; Gene expression; Human Genetics; Oncology

Many women with hormone receptor-positive early breast cancer can be managed effectively with endocrine therapies alone. However, additional systemic chemotherapy treatment is necessary for others. The clinical challenges in managing high-risk women are to identify existing and novel druggable targe...