Abnormal Effective Connectivity in the Brain is Involved in Auditory Verbal Hallucinations in Schizophrenia

• Published in: Neuroscience bulletin Vol. 33; no. 3; pp. 281 - 291
• Main Authors: Li, Baojuan, Cui, Long-Biao, Xi, Yi-Bin, Friston, Karl J., Guo, Fan, Wang, Hua-Ning, Zhang, Lin-Chuan, Bai, Yuan-Han, Tan, Qing-Rong, Yin, Hong, Lu, Hongbing
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.06.2017; Springer
• Subjects: Adult; Anatomy; Anesthesiology; Auditory Cortex - diagnostic imaging; Auditory Cortex - physiopathology; Biomedical and Life Sciences; Biomedicine; Broca Area - diagnostic imaging; Broca Area - physiopathology; Computational linguistics; Connectome - methods; Hallucinations - diagnostic imaging; Hallucinations - etiology; Hallucinations - physiopathology; Hallucinations and illusions; Hippocampus - diagnostic imaging; Hippocampus - physiopathology; Human Physiology; Humans; Language processing; Magnetic Resonance Imaging; Models, Theoretical; Natural language interfaces; Neurology; Neurosciences; Original; Original Article; Pain Medicine; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - physiopathology; Schizophrenia; Schizophrenia - complications; Schizophrenia - diagnostic imaging; Schizophrenia - physiopathology; Speech Perception - physiology; Thalamus - diagnostic imaging; Thalamus - physiopathology; 丘脑; 功能磁共振成像; 异常; 精神分裂症; 诊断价值; 语言处理; 连接强度; 额叶皮层; Schizophrenia; Stochastic dynamic causal modeling; Auditory verbal hallucinations; Effective connectivity

Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations（AVHs） in schizophrenia（SZ） remains unclear. In this study, we used stochastic dynamic causal modeling（s DCM） to quantify connections among the left dorsolateral...