A pilot study evaluating the safety and CD34+ cell mobilizing activity of escalating doses of plerixafor in healthy volunteers - Lemery, Steven J.; Hsieh, Matthew M.; Smith, Aleah; Rao, Sheila; Khuu, Hanh M.; Theresa, Donohue; Viano, Jennifer M.; Cook, Lisa; Goodwin, Rose; Boss, Carol; Calandra, Gary; Geller, Nancy; et al. (British journal of haematology, 2011)
Keywords: Adolescent; Adult; Antigens, CD34 - analysis; Benzylamines; Biological and medical sciences; BMT; CD34; clinical research; Cohort Studies; Colony-Forming Units Assay; Cyclams; Dose-Response Relationship, Drug; Female; Hematologic and hematopoietic diseases; Hematopoietic Stem Cell Mobilization - methods; Heterocyclic Compounds - administration & dosage; Heterocyclic Compounds - adverse effects; Heterocyclic Compounds - blood; Humans; Male; Medical sciences; Middle Aged; Pilot Projects; plerixafor; Receptors, CXCR4 - antagonists & inhibitors; stem cell mobilization/homing; Young Adult; Hematology; Plerixafor; Stem cell; Hematopoietic cell; Homograft; BMT; Clinical research; Cell subpopulation; Biological activity; stem cell mobilization/homing; Increasing dose; Mobilization; Healthy volunteer; Bone marrow; Graft; Homing phenomenon; Antagonist; CD34; CXCR4 chemokine receptor