Expression of Constitutive and Inducible Nitric Oxide Synthases in the Vascular Wall of Young and Aging Rats

• Published in: Circulation research Vol. 83; no. 3; pp. 279 - 286
• Main Authors: Cernadas, Maria R, Sanchez de Miguel, Lourdes, Garcia-Duran, Margarita, Gonzalez-Fernandez, Fernando, Millas, Inmaculada, Monton, Mercedes, Rodrigo, Jose, Rico, Luis, Fernandez, Patricia, de Frutos, Trinidad, Rodriguez-Feo, Juan A, Guerra, Jose, Caramelo, Carlos, Casado, Santos, Lopez-Farre, Antonio
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 10.08.1998; Lippincott; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Acetylcholine - pharmacology; Aging - metabolism; Animals; Aorta - metabolism; Arginine - analogs & derivatives; Arginine - pharmacology; Biological and medical sciences; Blood Pressure - drug effects; Blood vessels and receptors; Bradykinin - pharmacology; Calcium - metabolism; Cattle; Endothelium, Vascular - drug effects; Endothelium, Vascular - enzymology; Enzyme Induction; Enzyme Inhibitors - pharmacology; Fundamental and applied biological sciences. Psychology; Male; Nitric Oxide Synthase - biosynthesis; Nitric Oxide Synthase - genetics; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroprusside - pharmacology; Penicillamine - analogs & derivatives; Penicillamine - pharmacology; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents - pharmacology; Vertebrates: cardiovascular system; Immunohistochemistry; Rat; Enzyme; Isozyme; Ageing; Rodentia; 3',5'-GMP; Gene expression; Artery; Young animal; Nitric-oxide synthase; Vertebrata; Mammalia; Enzymatic activity; Blood vessel; Nitric oxide; Aged animal; Aorta; Circulatory system; Oxidoreductases; Endothelium derived relaxing factor; Calcium Cations

Two NO synthase (NOS) isoforms have been described in vessels, an endothelial constitutive NOS (eNOS) and an inducible NOS (iNOS). The purpose of the present study was to examine the endothelium-dependent and endothelium-independent hypotensive response in aging rats, analyzing the ability of their...