Temporal linear mode complexity as a surrogate measure of the effect of remifentanil on the central nervous system in healthy volunteers

• Published in: British journal of clinical pharmacology Vol. 71; no. 6; pp. 871 - 885
• Main Authors: Choi, Byung‐Moon, Shin, Da‐Huin, Noh, Moon‐Ho, Kim, Young‐Hac, Jeong, Yong‐Bo, Lee, Soo‐Han, Lee, Eun‐Kyung, Noh, Gyu‐Jeong
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2011; Blackwell; Blackwell Science Inc
• Subjects: Adult; Algorithms; Analgesics, Opioid - pharmacokinetics; Anesthetics, Intravenous - pharmacokinetics; Biological and medical sciences; Blood; Blood levels; Central nervous system; Central Nervous System - drug effects; combined effect and tolerance model; Data processing; Depression; Drug Tolerance; EEG; Electroencephalography - drug effects; Entropy; Feedback; feedback model; Female; Humans; Intravenous administration; Male; Medical sciences; Models, Biological; Models, Statistical; Opioids; Pharmacodynamics; Pharmacology. Drug treatments; Piperidines - pharmacokinetics; remifentanil; sigmoid Emax model; temporal linear mode complexity; Young Adult; Human; Agonist; Pharmacodynamics; Healthy subject; Toxicity; μ Opioid receptor; Central nervous system; Tolerance; Opiates; feedback model; Narcotic analgesic; Biological activity; Remifentanil; Complexity; temporal linear mode complexity; Feedback; Models; model; Phenylpiperidine derivatives; Sedative; sigmoid E; combined effect and tolerance model

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Remifentanil, an intravenous ultra short‐acting opioid, depresses central nervous system activity with an increase in the delta band power, and causes beta activation after discontinuation, resulting in a rebound of the processed electroencephalographic par...