Proteasomal Inhibition Promotes ATP-Binding Cassette Transporter A1 (ABCA1) and ABCG1 Expression and Cholesterol Efflux From Macrophages In Vitro and In Vivo

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 31; no. 9; pp. 1980 - 1987
• Main Authors: Ogura, Masatsune, Ayaori, Makoto, Terao, Yoshio, Hisada, Tetsuya, Iizuka, Maki, Takiguchi, Shunichi, Uto-Kondo, Harumi, Yakushiji, Emi, Nakaya, Kazuhiro, Sasaki, Makoto, Komatsu, Tomohiro, Ozasa, Hideki, Ohsuzu, Fumitaka, Ikewaki, Katsunori
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.09.2011; Lippincott Williams & Wilkins
• Subjects: Animals; Apolipoprotein A-I - physiology; Associated diseases and complications; Atherosclerosis (general aspects, experimental research); ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Sub-Family G, Member 1; ATP-Binding Cassette Transporters - analysis; ATP-Binding Cassette Transporters - physiology; Biological and medical sciences; Blood and lymphatic vessels; Boronic Acids - pharmacology; Bortezomib; Cardiology. Vascular system; Cells, Cultured; Cholesterol - metabolism; Diabetes. Impaired glucose tolerance; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Hep G2 Cells; Humans; Lipoproteins - analysis; Lipoproteins - physiology; Lipoproteins, HDL - physiology; Macrophages - metabolism; Medical sciences; Mice; Phosphorylation; Proteasome Endopeptidase Complex - physiology; Proteasome Inhibitors; Pyrazines - pharmacology; Ubiquitin-Protein Ligases - physiology; Ubiquitination; reverse cholesterol transport; Lipids; Cardiovascular disease; Macrophages; Cholesterol; Vascular disease; HDL; ubiquitin-proteasome system; ABC Transporter; Atherosclerosis; Lipoprotein HDL; Transport; ATP; Macrophage

OBJECTIVE—ATP-binding cassette transporter A1 (ABCA1) and ABCG1 are key molecules in an initial step of reverse cholesterol transport (RCT), a major antiatherogenic property of high-density lipoprotein (HDL). The ubiquitin-proteasome system (UPS) mediates nonlysosomal pathways for protein degradatio...