Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high‐dose chemotherapy

• Published in: British journal of clinical pharmacology Vol. 51; no. 1; pp. 61 - 70
• Main Authors: Huitema, Alwin D. R., Mathôt, Ron A. A., Tibben, Matthijs M., Schellens, Jan H. M., Rodenhuis, Sjoerd, Beijnen, Jos H.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.01.2001; Blackwell Science Inc
• Subjects: Adolescent; Adult; Algorithms; Analysis of Variance; Antineoplastic Agents, Alkylating - blood; Antineoplastic Agents, Alkylating - pharmacokinetics; Area Under Curve; Bayes Theorem; Female; high‐dose chemotherapy; Humans; Main Paper; Male; Middle Aged; Models, Biological; Neoplasms - blood; pharmacokinetics; Population; thioTEPA; Thiotepa - blood; Thiotepa - pharmacokinetics; Triethylenephosphoramide - blood

Aims  To study the population pharmacokinetics of thioTEPA and its main metabolite TEPA in patients receiving high‐dose chemotherapy consisting of thioTEPA (80–120 mg m−2 day−1), cyclophosphamide (1000–1500 mg m−2 day−1) and carboplatin (265–400 mg m−2 day−1) for 4 days. Methods  ThioTEPA and TEPA k...