Mesenchymal Stromal Cells in Animal Bleomycin Pulmonary Fibrosis Models: A Systematic Review

• Published in: Stem cells translational medicine Vol. 4; no. 12; pp. 1500 - 1510
• Main Authors: Srour, Nadim, Thébaud, Bernard
• Format: Journal Article
• Language: English
• Published: Durham, NC, USA AlphaMed Press 01.12.2015; Oxford University Press
• Subjects: Animal models; Animal studies; Animals; Bleomycin; Bleomycin - adverse effects; Bleomycin - pharmacology; Bone marrow; Chronic illnesses; Clinical trials; Collagen; Data analysis; Disease; Disease Models, Animal; Editorials; Embryonic Stem Cells - metabolism; Embryonic Stem Cells - pathology; Embryonic Stem Cells - transplantation; Fibrosis; Humans; Idiopathic pulmonary fibrosis; Induced Pluripotent Stem Cells - metabolism; Induced Pluripotent Stem Cells - pathology; Induced Pluripotent Stem Cells - transplantation; Lung diseases; Mesenchymal Stem Cell Transplantation; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Mesenchymal Stem Cells - pathology; Mesenchyme; Mortality; Pulmonary fibrosis; Pulmonary Fibrosis - chemically induced; Pulmonary Fibrosis - metabolism; Pulmonary Fibrosis - pathology; Pulmonary Fibrosis - therapy; Stem cells; Stromal cells; Studies; Systematic review; Therapy; Tissue Engineering and Regenerative Medicine; Therapy; Systematic review; Animal studies; Idiopathic pulmonary fibrosis; Stem cells

Data from 17 animal studies indicated mesenchymal stromal cell (MSC) therapy led to improvement in bleomycin‐induced lung collagen deposition, pulmonary fibrosis Ashcroft score (in most studies), histopathology, 14‐day survival in animal models, and reduced levels of markers of inflammation. Preclin...