Control of multiple arthropod vector infestations with subolesin/akirin vaccines

• Published in: Vaccine Vol. 31; no. 8; pp. 1187 - 1196
• Main Authors: Moreno-Cid, Juan A, Pérez de la Lastra, José M, Villar, Margarita, Jiménez, Maribel, Pinal, Rocío, Estrada-Peña, Agustín, Molina, Ricardo, Lucientes, Javier, Gortázar, Christian, de la Fuente, José
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 06.02.2013; Elsevier; Elsevier Limited
• Subjects: Akirin; Allergy and Immunology; Amino acids; animal and human health; Animals; anthropogenic activities; Antigens; Applied microbiology; Arachnids; Arthropod; Arthropod Proteins - administration & dosage; Arthropod Proteins - genetics; Arthropod Proteins - immunology; Arthropod Vectors - physiology; Arthropoda; Biological and medical sciences; chimerism; Colleges & universities; Culicidae; Culicidae - physiology; disease vectors; Eggs; epitopes; Experiments; Female; Females; Fertility; Fever; Fundamental and applied biological sciences. Psychology; Gene expression; Humans; Immunology; Insects; Ixodidae; Lyme disease; Male; Mice; Mice, Inbred BALB C; Microbiology; Molecular Sequence Data; molting; Mortality; Mosquito; Mosquitoes; Oviposition; Phlebotominae; Proteins; Psychodidae - physiology; Recombinant Fusion Proteins - administration & dosage; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - immunology; Sand & gravel; Sand fly; Sequence Analysis, DNA; Signal transduction; Subolesin; Survival Analysis; Tick; Tick Infestations - immunology; Tick Infestations - prevention & control; ticks; Ticks - physiology; Tropical diseases; vaccination; Vaccination - methods; Vaccine; vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; vector control; vector-borne diseases; Spain; Sand fly; Immunology; Mosquito; Subolesin; Akirin; Arthropod; Tick; Vaccine; Parasitiformes; Arachnida; Acari; Ixodida; Arthropoda; Invertebrata; Vector; Ixodidae
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2012.12.073

Highlights ► Chimeras Q38 and Q41 containing tick subolesin (SUB) and mosquito akirin (AKR) protective epitopes were made. ► Vaccination with SUB, AKR and SUB/AKR chimeras controls tick, mosquito and sand fly infestations in mice. ► Vaccination with SUB had the highest efficacy across all vector species. ► Vaccination with Q41 had the highest efficacy in mosquitoes by reducing female survival and fertility. ► Vaccination with Q38 had the highest effect on reducing mosquito and sand fly oviposition.