Pneumococcal serotype-specific cut-offs based on antibody responses to pneumococcal polysaccharide vaccination in healthy adults

• Published in: Vaccine Vol. 39; no. 21; pp. 2850 - 2856
• Main Authors: Park, Miguel A., Jenkins, Sarah M., Smith, Carin Y., Pyle, Regan C., Sacco, Keith A., Ryu, Euijung, Hagan, John B., Joshi, Avni Y., Snyder, Melissa R., Abraham, Roshini S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 18.05.2021; Elsevier Limited
• Subjects: Adults; Allergy and Immunology; Antibodies; antibody formation; Antibody response; Antigens; diagnostic techniques; Humoral immunodeficiency; IgG antibody; Immunoglobulin G; Immunology; immunosuppression; Multiplex bead analysis; Pneumococcal; Pneumococcal conjugate vaccine; Pneumococcal polysaccharide vaccine; Pneumovax; Polysaccharides; Prevnar; Primary immunodeficiency; Serotype; Serotypes; Streptococcus infections; Streptococcus pneumoniae; Testing laboratories; Vaccination; Vaccines; United States > US; Pneumococcal conjugate vaccine; PCV; Multiplex bead analysis; Pneumovax; PID; IEI; Prevnar; Antibody response; Primary immunodeficiency; Pneumococcal; Pneumococcal polysaccharide vaccine; PPV; Humoral immunodeficiency; Serotype; primary immunodeficiencies; inborn errors of immunity

•IgG pneumococcal antibodies assessed in healthy pneumococcal-naïve adults.•Serotype-specific thresholds defined to pneumococcal polysaccharide vaccination.•The serotype-cutoffs is used for interpretation of pneumococcal antibody responses.•It may be useful in patients with humoral immunodeficiencie...