Receptor-mediated mitophagy in yeast and mammalian systems

• Published in: Cell research Vol. 24; no. 7; pp. 787 - 795
• Main Authors: Liu, Lei, Sakakibara, Kaori, Chen, Quan, Okamoto, Koji
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2014; Nature Publishing Group
• Subjects: 631/80/39/2348; 631/80/642/333; 631/80/86; Animals; Apoptosis; Autophagy-Related Protein 8 Family; Autophagy-Related Proteins; Biomedical and Life Sciences; Casein Kinase II - metabolism; Cell Biology; Cell Hypoxia; Humans; Hypoxia; Life Sciences; Mammals; Membrane Proteins - physiology; Microtubule-Associated Proteins - metabolism; Mitochondria - metabolism; Mitochondrial Degradation; Mitochondrial Dynamics - physiology; Mitochondrial Proteins - physiology; Phosphorylation; Proto-Oncogene Proteins - physiology; Receptors, Cytoplasmic and Nuclear - biosynthesis; Receptors, Cytoplasmic and Nuclear - physiology; Review; Saccharomyces cerevisiae - ultrastructure; Saccharomyces cerevisiae Proteins - biosynthesis; Saccharomyces cerevisiae Proteins - metabolism; Saccharomyces cerevisiae Proteins - physiology; src-Family Kinases - metabolism; Tumor Suppressor Proteins - physiology; Vesicular Transport Proteins - metabolism; Yeasts; 去磷酸化; 受体介导; 哺乳动物细胞; 系统; 线粒体; 蛋白质; 酪蛋白激酶; 酵母; protein phosphorylation; quality control; mitochondrial stress; mitochondria; mitophagy receptor; selective autophagy

Mitophagy, or mitochondria autophagy, plays a critical role in selective removal of damaged or unwanted mitochondria. Several protein receptors, including Atg32 in yeast, NIX/BNIP3L, BNIP3 and FUNDCI in mammalian systems, directly act in mitophagy. Atg32 interacts with Atg8 and Atgll on the surface...