Radiation Sensitivity of Human Bone Marrow Fibroblast Colony Forming Unit (CFU-F) to Various Radiation Sources

The effects of 60 cobalt gamma rays (60Co), tritiated water (HTO) beta rays and 252 californium (252Cf) neutrons on stromal stem cells (CFU-F) from human fresh bone marrow were studied using an in vitro cell culture technique. Based on the survival curves of CFU-F, the D0 values of 60Co, HTO and 252...

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Published inJOURNAL OF RADIATION RESEARCH Vol. 29; no. 3; pp. 182 - 188
Main Authors Shigeta, C, Tanaka, K, Oguma, N, Kamada, N, Ohkita, T
Format Journal Article
LanguageJapanese
English
Published England THE JAPAN RADIATION RESEARCH SOCIETY 1988
Oxford University Press
Subjects
Beta Particles
Bone Marrow - radiation effects
Bone Marrow Cells
Californium
Cell Survival - radiation effects
Cells, Cultured
Cobalt Radioisotopes
Fibroblasts - radiation effects
Gamma Rays
Hematopoietic Stem Cells - radiation effects
Humans
Neutrons
Radiation Dosage
Radiation Tolerance
Tritium
Water
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Abstract The effects of 60 cobalt gamma rays (60Co), tritiated water (HTO) beta rays and 252 californium (252Cf) neutrons on stromal stem cells (CFU-F) from human fresh bone marrow were studied using an in vitro cell culture technique. Based on the survival curves of CFU-F, the D0 values of 60Co, HTO and 252Cf were 124 ± 30, 92 ± 12 and 60 ± 11 rad, respectively. From the D0values of 60Co gamma rays, the relative biological effectiveness (RBE) of HTO beta rays and 252Cf neutrons were calculated to be 1.3 and 2.1. However, due to the difference in the survival curves with or without initial shoulder, the RBEs of HTO and 252Cf were dependent on the range of radiation dose. Both RBEs became higher than 3 in the low dose range of radiation (under 100 rad).
AbstractList The effects of 60 cobalt gamma rays (60Co), tritiated water (HTO) beta rays and 252 californium (252Cf) neutrons on stromal stem cells (CFU-F) from human fresh bone marrow were studied using an in vitro cell culture technique. Based on the survival curves of CFU-F, the D0 values of 60Co, HTO and 252Cf were 124 ± 30, 92 ± 12 and 60 ± 11 rad, respectively. From the D0 values of 60Co gamma rays, the relative biological effectiveness (RBE) of HTO beta rays and 252Cf neutrons were calculated to be 1.3 and 2.1. However, due to the difference in the survival curves with or without initial shoulder, the RBEs of HTO and 252Cf were dependent on the range of radiation dose. Both RBEs became higher than 3 in the low dose range of radiation (under 100 rad).
The effects of 60 cobalt gamma rays (60Co), tritiated water (HTO) beta rays and 252 californium (252Cf) neutrons on stromal stem cells (CFU-F) from human fresh bone marrow were studied using an in vitro cell culture technique. Based on the survival curves of CFU-F, the D0 values of 60Co, HTO and 252Cf were 124 ± 30, 92 ± 12 and 60 ± 11 rad, respectively. From the D0values of 60Co gamma rays, the relative biological effectiveness (RBE) of HTO beta rays and 252Cf neutrons were calculated to be 1.3 and 2.1. However, due to the difference in the survival curves with or without initial shoulder, the RBEs of HTO and 252Cf were dependent on the range of radiation dose. Both RBEs became higher than 3 in the low dose range of radiation (under 100 rad).
Author CHIHARU SHIGETA
TAKESHI OHKITA
KIMIO TANAKA
NANAO KAMADA
NOBUO OGUMA
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Departrnem of Hematology. Research Institute for Nuclear Medicine and Biology
Nagoya National Hospital
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Oxford University Press
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Snippet The effects of 60 cobalt gamma rays (60Co), tritiated water (HTO) beta rays and 252 californium (252Cf) neutrons on stromal stem cells (CFU-F) from human fresh...
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SubjectTerms Beta Particles
Bone Marrow - radiation effects
Bone Marrow Cells
Californium
Cell Survival - radiation effects
Cells, Cultured
Cobalt Radioisotopes
Fibroblasts - radiation effects
Gamma Rays
Hematopoietic Stem Cells - radiation effects
Humans
Neutrons
Radiation Dosage
Radiation Tolerance
Tritium
Water
Title Radiation Sensitivity of Human Bone Marrow Fibroblast Colony Forming Unit (CFU-F) to Various Radiation Sources
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