Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism

• Published in: Scientific reports Vol. 8; no. 1; pp. 9814 - 14
• Main Authors: Lund, Jenny, Aas, Vigdis, Tingstad, Ragna H., Van Hees, Alfons, Nikolić, Nataša
• Format: Journal Article
• Language: English; Norwegian
• Published: London Nature Publishing Group UK 29.06.2018; Nature Publishing Group
• Subjects: 14/63; 38; 38/77; 38/90; 631/57; 631/57/1464; 631/61/32; 631/92/1643; 82; 82/1; Energy metabolism; Energy sources; Fatty acids; Glucose; Glucose metabolism; Glycogen; Glycolysis; Humanities and Social Sciences; Lactic acid; Metabolism; multidisciplinary; Muscles; Myotubes; Oleic acid; Oxidation; Palmitic acid; Pyruvic acid; Science; Science (multidisciplinary); Skeletal muscle

Once assumed only to be a waste product of anaerobe glycolytic activity, lactate is now recognized as an energy source in skeletal muscles. While lactate metabolism has been extensively studied in vivo , underlying cellular processes are poorly described. This study aimed to examine lactate metaboli...